Tag: science

Hardy, Radiation-Resistant Organism Could Rewrite Your Genetic Code to Cure High Cholesterol

Scientists are programming one of the world’s hardiest, most radiation-resistant organisms to rewrite a specific gene, allowing them to cure a common type of inherited high cholesterol. Dubbed TnpB and originating from the bacterium Deinococcus radiodurans, this exceptionally robust microbe also survives cold, dehydration, vacuum, and acid, making it an ideal tool for genetic editing.

Although the team has only tested its “genetic scissors” on mice models with an inherited predisposition to a type of high cholesterol called hypercholesterolemia, which currently affects 31 million Americans, the researchers believe their approach will one day allow them to cure high cholesterol in humans by essentially rewiring their genetic code.

Reprogramming TnpB to Cure High Cholesterol

In the published study outlining the new genetic reprogramming approach, the researchers note that genetic editing has shown significant promise in editing certain inherited health conditions by essentially “reprogramming” specialized bacteria to genetically edit the faulty gene in a person’s genetic code with a properly functioning one. However, the process, made famous by the CRISPR gene editing tool, has resulted in mixed successes.

One of the primary limiting factors of the CRISPR-Cas organism most commonly used in genetic editing is its size. According to the study authors, the microbe is too large to be precisely targeted, which “creates challenges when trying to deliver them to the right cells in the body.”

More recently, researchers in genetic editing have begun to focus on the organism’s “evolutionary progenitors,” some of which are much smaller than the CRISPR-Cas microbe. Among the most promising is TnpB, whose smaller size and hardiness offer scientists a new path for genetic editing.

These smaller progenitors are less efficient at reprogramming and show limited targeting ability due to their limited recognition requirements when binding DNA than the larger CRISPR-Cas microbes. Now, the researchers behind this study say they may have finally overcome that limitation, resulting in a much more efficient method of targeting TnpB to cure high cholesterol.

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New study finds personal care products cause development disruptions in children

A link between the use of personal care products such as lotions, ointments, shampoos and hair conditioners and higher levels of endocrine-disrupting chemicals called phthalates in children was directly correlated in a new study. Published in the journal, Environmental Health Perspectives, the study, which was conducted at George Mason University, examined clinical data from urine samples collected from 630 children ages 4 to 8.

The study linked endocrine disruptors, which “mimic, block or interfere with the body’s own hormones,” to disruptions in children “during key developmental moments,” NPR reported.

“We found that the recent use of several different types of skin care products was associated with higher urinary concentrations of several different types of phthalates,” Michael Bloom, a professor and researcher at George Mason University, said.

While prior studies have found similar results in infants and pregnant women, the link hasn’t been made with children between the ages of 4 and 8. But the new study “provides clear evidence of the links between kids’ exposures and a range of personal care products, Dr. Lynn Goldman, a pediatrician and epidemiologist who formerly served as an assistant administrator for toxic substances at the Environmental Protection Agency,” said, according to NPR.

“I think we should be much more concerned than we have been in the past about the fact that these [chemicals] might be allowed in cosmetics and personal care products,” Goldman said.

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Ingredient found in Doritos turns mouse’s skin transparent, may have medical applications

Scientists at Stanford University were recently able to make a mouse’s skin transparent using a common food dye, something the study’s author told Fox News Digital could have exciting benefits for humans once additional research is conducted. 

The paper, titled “Achieving optical transparency in live animals with absorbing molecules,” was published in the journal “Science” on Sept. 5. 

In it, the researchers used a solution of red tartrazine, a food dye known as FD&C Yellow 5, on the abdomen, scalp and hindlimb of a sedated mouse, said a release from Stanford University.

The dye turned the mouse’s skin red, which then made the skin appear transparent – and the mouse’s organs were visible to the naked eye, said the release. 

“The researchers believe this is the first non-invasive approach to achieving visibility of a mouse’s living internal organs,” the release noted. 

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The science is in. Climate alarmism can end. Since 1959 increases in atmospheric CO2 is due to sea surface temperature

Last month, Japanese researcher Dai Ato published a study that examined the relationship between atmospheric carbon dioxide (CO₂) levels and human emissions, with sea surface temperature as a key factor.

The findings reject the theory that human-caused emissions are the primary driver of atmospheric CO₂ increase. Instead, the study concludes that sea surface temperature plays a dominant role in regulating CO₂ levels and no human impact is observed.

Ato’s study was published on 16 August in Science of Climate Change, a not-for-profit independent scientific journal dedicated to the publication and discussion of research articles, short communications and review papers on all aspects of climate change.

The multivariate analysis used publicly available data from prominent climate research and energy-related organisations. He found that human emissions were not a determining factor in any of the regression models. 

A regression model is a statistical technique used to estimate the relationship between a response (dependent) variable and a set of explanatory (independent) variables. 

The study concluded that sea surface temperature (“SST”), not human emissions, was the independent determinant of the annual increase in atmospheric CO₂ concentration.

“This study is the first to use multiple regression analysis to demonstrate that the independent determinant of the annual increase in atmospheric CO₂ concentration was SST, which showed strong predictive ability. However, human CO₂ emissions were irrelevant. This result indicates that atmospheric CO₂ has fluctuated as natural phenomenon, regardless of human activity,” the study says.

“The global SST has been the main determinant of annual increases in atmospheric CO₂ concentrations since 1959. No human impact was observed.”

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Egyptologists uncover 2,500 year-old observatory full of precise tools

Egyptologists have excavated a nearly 9,150-square-foot astronomical observatory in modern-day Tell el-Faraeen dating back to the sixth century BCE—the first and largest of its kind from that era. In an August 23 announcement from Egypt’s Ministry of Tourism and Antiquities (interpreted from Arabic to English using Google Translate), the mud brick structure contained numerous tools that, although comparatively simple in design, allowed for the precise study and measurement of solar calendrical dates related to Egyptian religious rites, royal coronations, and agricultural plans.

The facility is located within a sprawling archeological site now known as the Temple of Buto (the Greek name of the Egyptian god, Wadjet), and is located about 50 miles east of Alexandria. Built in the southeastern portion of the temple, the astronomical complex featured an east-facing entrance for sunrises, an L-shaped open central hall supported by columns, and a high, inward sloping mud brick wall “resembling the style of the Egyptian edifice known in temple entrances,” according to the government’s statement.

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Scientists Detect Invisible Electric Field Around Earth For First Time

An invisible, weak energy field wrapped around our planet Earth has finally been detected and measured.

It’s called the ambipolar field, an electric field first hypothesized more than 60 years ago, and its discovery will change the way we study and understand the behavior and evolution of our beautiful, ever-changing world.

“Any planet with an atmosphere should have an ambipolar field,” says astronomer Glyn Collinson of NASA’s Goddard Space Flight Center.

“Now that we’ve finally measured it, we can begin learning how it’s shaped our planet as well as others over time.”

Earth isn’t just a blob of dirt sitting inert in space. It’s surrounded by all sorts of fields. There’s the gravity field. We don’t know a lot about gravity, especially considering how ubiquitous it is, but without gravity we wouldn’t have a planet. Gravity also helps keep the atmosphere snug against the surface.

There’s also the magnetic field, which is generated by the rotating, conducting material in Earth’s interior, converting kinetic energy into the magnetic field that spins out into space. This protects our planet from the effects of the solar wind and radiation, and also helps to keep the atmosphere from blowing away.

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Stone Age builders had engineering savvy, finds study of 6000-year-old monument

The Neolithic farmers and herders who built a massive stone chamber in southern Spain nearly 6,000 years ago possessed a good rudimentary grasp of physics, geometry, geology and architectural principles, finds a detailed study of the site.

Using data from a high-resolution laser scan, as well as unpublished photos and diagrams from earlier excavations, archaeologists pieced together a probable construction process for the monument known as the Dolmen of Menga. Their findings, published on 23 August in Science Advances1, reveal new insights into the structure and its Neolithic builders’ technical abilities.

The dolmen pre-dates the main stone circle at Stonehenge in the United Kingdom by about 1,000 years, but the construction process described in the study would have involved similar techniques and demanded a similar level of engineering.

“These people had no blueprints to work with, nor, as far as we know, any previous experience at building something like this,” says study co-author Leonardo García Sanjuán, an archaeologist at the University of Seville in Spain. “And yet, they understood how to fit together huge blocks of stone” with “a precision that would keep the monument intact for nearly 6,000 years”.

“There’s no way you could do that without at least a basic working knowledge of science,” he adds.

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CO2 Has Been Indicted by Consensus, Not Real Science or Critical Thinking

When asking those who believe that CO2 is a major climate antagonist to make their strongest argument, their most common response is: “CO2 has been identified as the primary Climate culprit by the majority of experts (e.g., climatologists) and scientific organizations (e.g., the IPCC).” This is clearly a consensus claim.

I’ve repeatedly warned that one of the major fights we are in, is to defend genuine Science, as its enemies are actively trying to replace it with political science. This situation is a dead giveaway, as consensus is the currency of politics, NOT Science!

Put another way, the claim of consensus is deference to authority. They are saying don’t ask any questions! Just be quiet as others know a lot more about this matter than you do. Further, they continue, it’s not possible that all those experts would be lying to us!

Both of these are very reasonable viewpoints. However, whether or not they should end the conversation is the question. Let’s look at a recent very close Science parallel for enlightenment. Here is a layperson’s history of what happened…

There are roughly 8 Billion people on the planet who periodically experience stomach ailments (i.e., gastrointestinal distress). The concern often is: will these common human pains turn into something much more major — like an ulcer?

An ulcer is a perforation of the stomach lining, which is a serious matter, and there are about 4 Million cases of these in the US, every year — so it is relatively common.

For nearly 200 years the medical establishment believed that stomach ulcers (technically peptic ulcers) were caused by stress. The hypothesis was that stress produced excess (gastric) acid in the stomach, which (in turn) eventually ate away some of the stomach’s lining. (The first connection between these was made in 1822.)

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Under The Skin: The Internet Of Bio-NanoThings

The Internet of Things (IoT) has become an important research topic in the last decade, where things refer to interconnected machines and objects with embedded computing capabilities employed to extend the Internet to many application domains. While research and development continue for general IoT devices, there are many application domains where very tiny, concealable, and non-intrusive Things are needed.

The properties of recently studied nanomaterials, such as graphene, have inspired the concept of Internet of NanoThings (IoNT), based on the interconnection of nanoscale devices. Despite being an enabler for many applications, the artificial nature of IoNT devices can be detrimental where the deployment of NanoThings could result in unwanted effects on health or pollution. The novel paradigm of the Internet of Bio-Nano Things (IoBNT) is introduced in this paper by stemming from synthetic biology and nanotechnology tools that allow the engineering of biological embedded computing devices.

Based on biological cells, and their functionalities in the biochemical domain, Bio-NanoThings promise to enable applications such as intra-body sensing and actuation networks, and environmental control of toxic agents and pollution. The IoBNT stands as a paradigm-shifting concept for communication and network engineering, where novel challenges are faced to develop efficient and safe techniques for the exchange of information, interaction, and networking within the biochemical domain, while enabling an interface to the electrical domain of the Internet.

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47-Year-Old ‘Wow! Signal’ Mystery Solved? Arecibo Observatory Scientists Think They Have an Answer

A team of scientists from the Planetary Habitability Laboratory (PHL) at the University of Puerto Rico at Arecibo believe they may have finally solved the 47-year-old mystery of the infamous “Wow! Signal.”

Detected by the Ohio State University Big Ear Telescope on August 15th, 1977, the Wow! Signal got its name because astronomer Jerry R. Ehman was so impressed he wrote “WOW” in the signal printout’s margins. Since then, the signal has continued to fascinate the scientific community, including the possibility that it may have been sent by an extraterrestrial civilization light years from Earth due to its high power, strong signal-to-noise ratio, and narrow bandwidth.

Unfortunately, various efforts to detect a repeat of the signal, which had a frequency and duration that didn’t match any known natural phenomenon, have come up empty, leaving the exact nature and origin of the potentially artificial signal unsolved. Several efforts in the ensuing decades have tried to offer potentially natural explanations for the signal. However, those attempts have also come up short of providing a definitive solution, leaving scientists to wonder if the Wow! Signal was indeed of extraterrestrial origin.

Now, the PHL’s lead researcher, Professor Abel Méndez, and his colleagues say that the vast amount of data they collected with the Arecibo’s iconic 305-meter telescope before it collapsed in 2020, as well as additional data collected by the facility’s 12-meter telescope since 2023, has led them to a potentially ‘astronomical’ solution to this enduring mystery.

“The Wow! Signal may have been caused by a unique astrophysical event: the sudden brightening of a cold hydrogen cloud due to stimulated emission from a transient strong radiation source, such as a magnetar flare or a soft gamma repeater (SGR),” Méndez told The Debrief. “These rare events might cause hydrogen clouds to momentarily shine much brighter, potentially explaining the fleeting nature of the Wow! Signal.”

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