Tag: dna

De-Extinct Dire Wolves Ready To Breed; Bioscience Company Pushes Forward Multiple Projects

Colossal Biosciences has announced that its de-extinct dire wolves—Romulus, Remus, and Khaleesi—are now breeding-aged and the firm plans to expand the pack later this year. The development marks a significant step for the Texas-based company in its mission to restore extinct species through genetic engineering.

The dire wolf pups, born in late 2024 and early 2025, represent the world’s first de-extinct animals. They have thrived in a secure 2,000-acre preserve, reaching milestones like learning to process whole deer carcasses and now showing readiness for natural breeding behaviors.

“The dire wolf pack is actually breeding-aged at this point,” Matt James, Colossal’s chief animal officer, said, adding “But we will initially grow the pack through assisted reproduction while we create new, genetically diverse individuals.”

The company intends to engineer two to four additional pups to boost genetic diversity before allowing full natural breeding. “The plan is to create an inter-breedable population of dire wolves in which they would eventually breed naturally to create a sustainable population of the world’s first de-extinct species,” James continued.

He further added, “We will grow the population through assisted reproduction initially and then eventually only rely on natural breeding.”

“The dire wolves are doing great,” Ben Lamm, Colossal’s CEO and co-founder, stated., adding “The three dire wolves live on a 2,000-acre secure, expansive ecological preserve that allows us to monitor and manage them while providing them a semi-wild habitat to thrive in. We hope to have more dire wolf pups by the end of the year.”

Colossal reconstructed the dire wolf genome from ancient DNA fragments in bone samples, including a 72,000-year-old skull. Scientists then edited gray wolf embryos to incorporate key traits: a white coat, larger teeth, more muscular build, and distinctive howl. Embryos were implanted in surrogate dogs, with births by caesarean section.

Keep reading

DNA test uncovers kidnapping, mob, police corruption

A Henderson man named Paul Fronczak had no idea that his entire life would be turned upside down when he bought a home DNA test kit. The results of that test took away his name, his family, and everything he knew about his life to that point.

It also opened up a multi-layered rabbit hole involving an infamous kidnapping, police corruption, the mob, and dark secrets buried for six decades.

8 News Now chief investigator George Knapp has followed this very twisted tale for decades and pushed to get answers to mysteries long thought unsolvable.

Paul Fronczak’s quest started with a single objective: find a kidnapped baby

This then exploded into a Byzantine maze of twists and subplots, too improbable even for a true crime miniseries. In the 14 years since he first contacted us for help, he’s dug up solid answers, but each answer led to more head-spinning questions. He still uses the name Paul Fronczak, but after years of searching, he sometimes feels as if he’s been living someone else’s life.

The initial mystery started at a Chicago hospital in 1964.  One day after the birth of Paul Fronczak, a woman dressed as a nurse kidnapped the baby and vanished. Police, the public, and the FBI conducted a massive manhunt. The story made international headlines, but the baby was gone.

Nearly two years later, an infant found abandoned on a sidewalk in New Jersey was presented by law enforcement to the brokenhearted Fronczak parents, who took one look and said that’s their missing boy.

The child grew up in a loving home but had nagging questions about why he looked so different from the rest of the Fronczak family.  

Fast forward to 2012, the adopted Paul Fronczak was living in Henderson and, almost as a lark, took a DNA test along with his parents. The test showed he was not the Fronczaks’ son and was not the kidnapped baby.

So who was he, and what happened to his namesake? That was the start of his quest, despite the official investigation from the FBI ending decades ago.

Keep reading

5 More Highly Concerning Technologies in Development

There has been quite a growing number of highly concerning technologies in development, as reflected in an article I wrote, while highlighting ethical, moral and safety issues/concerns… 

As a follow-up, here are 5 more highly concerning technologies currently in development, again having a number of serious issues/concerns.

1.Google’s DeepMind AlphaGenome Human “designer” DNA

There’s been a lot of attention given to DNA. Deciphering how, at the molecular level, genomic DNA sequencing and resulting genetic expression occurs. 

In other words, given that the smallest alterations to DNA can change an organism’s physical appearance, ability to regulate or control biological functions, or affect its susceptibility to disease… there is indeed much to be gained from understanding the related underlying mechanisms. 

-Consider Google’s DeepMind, having plans to launch AlphaGenome, a new AI tool that looks at how human DNA sequences vary. How this technology can be used to detect DNA sequences for predictive purposes… 

This is what Google DeepMind has to say (excerpt):  

“Our AlphaGenome model takes a long DNA sequence as input – up to 1 million letters, also known as base pairs – and predicts thousands of molecular properties that characterize its regulatory activity. It can also assess the effects of genetic variants or mutations by comparing predictions of mutated sequences with those of non-mutated sequences…”

Further, stated by Google DeepMind (website), the research project’s goals are to 1.Understand disease, 2.Understand how to apply synthetic biology and 3.Have deeper insight into how DNA works. 

In light of this new technology, when DNA’s building blocks are understood, consider how it could be used for “enhancement.” How it could be used for human “designer” DNA. 

Consider the controversy surrounding this, as for instance, shown in the 1997 movie entitled “GATTACA.” -An absorbing futuristic science fiction movie set in a dystopia where selective breeding through designer DNA was commonly practiced. In other words, the human race was driven by eugenics and transhumanism.

In this movie, the controversy was over the discrimination of those having “good genes” when comparing people with “bad genes.” Who decides what are “good genes” or “bad genes?”

-As “designer” DNA progresses, we’re getting closer to a world where genetic enhancement, for example, selectively bred babies, could become the norm.  

This raises a number of serious issues/concerns when considering the technocratic overlords overseeing this future in the name of next-phase “evolution,” viewing us humans as nothing more than mechanistic bio-hackable soulless automatons.

Keep reading

UK Biobank Failures Expose the Permanent Cost of Sharing Genetic and Medical Records

The genetic sequences, medical scans, and lifestyle records of half a million British volunteers spent days listed for sale on Alibaba before anyone at UK Biobank noticed.

Three academic institutions, since banned from the platform, had quietly walked the data out through a research system that was supposed to keep it under lock and key.

At least one of the three Alibaba listings appeared to contain the full dataset covering every one of the 500,000 participants who handed over their blood, their DNA, and decades of personal health information on the understanding it would be used for medical research.

The UK government confirmed the breach on Thursday. Technology minister Ian Murray told the House of Commons that Biobank had flagged the incident on Monday, and that the Chinese government and Alibaba had cooperated to pull the listings down before any purchases went through. Murray thanked Beijing directly for its “speed and seriousness” in taking down the data, a sentence that carries some weight given the three research institutions identified as the source are Chinese, though officials have declined to draw conclusions about intent.

Professor Rory Collins, Biobank’s chief executive and principal investigator, issued a statement saying the listings “were swiftly removed before any purchases were made.” He apologized to participants and confirmed that access to the research platform had been suspended while the organization installs file size limits designed to stop researchers from walking off with bulk datasets.

An automated checking system to vet outgoing files is not expected to be ready until late 2026.

The sales listing is not the scandal. The scandal is what the sales listing reveals about how often Biobank’s data has already been exposed and where it now sits.

Prof Luc Rocher of the Oxford Internet Institute has been tracking the problem and maintains a public record of known incidents. By his count, the Alibaba posting is “the 198th known exposure of UK Biobank data since last summer.” Rocher added that the data “is not just available for sale, it also remains available online for anyone to download today.” Researchers have repeatedly uploaded the dataset to code-sharing platforms by accident, and copies have since been replicated across the web. Taking down one Alibaba listing does nothing about the other 197.

Biobank’s response to this pattern has been to emphasize that the data is “de-identified” and that no participant has been knowingly re-identified. The reassurance rests on a technical claim that does not survive contact with the evidence.

Keep reading

New Genetic Study of the Famous ‘Shroud of Turin’ Reopens Debate Over the Controversial Relic’s Origins

The Shroud of Turin, purported by many to have been the burial cloth that once covered the body of Jesus at the time of his burial, remains one of the most controversial relics in all of history.

For centuries, the shroud was believed to preserve rare historical evidence of the seemingly miraculous events described in the New Testament. However, by the 20th century, a growing number of scholars had come to believe the shroud’s origins were likely to be far more recent: perhaps the result of a clever forgery produced sometime in the Middle Ages.

Now, according to the findings of a new genetic study, it seems the lingering questions over the shroud and its origins are far from being settled, revealing a wide range of encounters the Turin Shroud has had with humans, animals, and other objects, and offering new clues about the environments that it met over time.

Obscure Origins

The mysterious shroud, which has remained a curiosity to scholars for centuries, has been preserved in Turin, Italy, since the late 16th century. The relic depicts the ghostly image of what appears to be a male human body, as well as evidence of markings that indicate blood in the positions on the body that are traditionally consistent with New Testament accounts of the injuries Jesus bore at the time of his crucifixion.

Over the decades, studies have sought to help determine the true origins of the unusual relic, leading to a range of theories about its provenance. After centuries of debate among scholars, in 1978, scientific efforts to determine the shroud’s origins were undertaken, which included samples with remnants of DNA that its woven material has collected over time.

Ultimately, testing completed in 1988 suggested that the shroud most likely dated to no earlier than the 13th century, although the debate over its history has continued.

Reopening the Debate

Now, in a new international study effort led by Italian scientists, recent genetic studies involving the original samples collected in 1978 are helping to shed additional light on the complex nature of the interactions the shroud has had with its environment over the centuries.

The team, whose findings appear in a new preprint paper that appears on the bioRxiv website, reports that their analysis showcases the preservation conditions of the shroud over time, as well as interactions it has had with its environment that reveal “its biological complexity through rigorous DNA and metagenomic analyses.”

According to the study’s authors, “The possible existence of the Shroud prior to the first documented information places the long journey of this artifact into a Middle or Near East geographical context, with a potential historical age preceding the Sacking of Constantinople in

1204.” Sometime later, scholars believe the shroud was moved to a new location in Western Europe, before it resurfaced again near the French commune of Lirey in the early to mid 1350s.

Some of the questions about the shroud’s journey throughout the centuries is evidenced by the genetic material it carries, and through analysis, the study’s authors hoped to learn about the kinds of environments where it had been kept, dividing the chronological history of the relic into a “pre-1204” period that it was believed to have been kept in the ancient Near East, and what the team refers to as “a plausible ‘post-1353’ location in western Europe.”

“These two hypothetical temporal and spatial differentiations may be reflected in the variation of DNA data obtained from the Shroud,” the study’s authors say.

Keep reading

Trace DNA Found on Shroud of Turin Suggests ‘Unexpected’ Connection to India

Scientists examining DNA contained on the Shroud of Turin were surprised to find evidence indicating that the materials used to make the relic may have originated in India. The fascinating study reportedly involved researchers re-examining samples collected from the controversial artifact in 1978, with the intention of gaining new insights from the genetic information left behind on the pieces. In detailing their analysis of the trace DNA, the scientists revealed that they detected a remarkably diverse array of plants and animals that had their proverbial prints on the relic.

But what particularly intrigued scientists were their findings with regard to the people who came into contact with the shroud. Specifically, the researchers noted that nearly 40 percent of the human DNA found on the relic was from “Indian lineages.” This “unexpected” result, they noted, “is potentially linked to historical interactions associated with importing linen or yarn from regions near the Indus Valley.” Alas, given the complex history of the relic, the scientists were unable to determine its age based on the trace DNA from “centuries of social, cultural, and ecological engagement” with the shroud.

Keep reading

Ted Bundy named as killer of teen girl who left a Halloween party and never returned after DNA breakthrough

Notorious serial killer Ted Bundy has been identified as the murderer of a teenage girl who vanished on Halloween night more than half a century ago.

Laura Ann Aime, 17, was last seen alive at a party in Utah County on October 31, 1974, when she told friends she was heading out to buy cigarettes. She never returned.

Around a month later on November 27, 1974, her naked body was found in an embankment up in the mountains near American Fork Canyon Road. The teen had been raped and strangled.

For decades, her murder has been linked to Bundy, with the serial killer giving a deathbed confession to killing Aime and at least 29 other victims before he was sent to the electric chair in January 1989.

But, her case remained unsolved for the next 37 years, with investigators needing more evidence to close the investigation once and for all.

That evidence finally arrived in the way of a breakthrough in DNA evidence last month.

In a press conference on Wednesday, Utah County Sheriff Mike Smith announced that advanced DNA testing of bodily fluids found on the victim had proven Bundy to be the killer once and for all.  

‘Although Bundy did claim that he committed the murder of Laura, the confession he gave was deemed to be not enough evidence to close the case and rule out any other party having had committed this crime, as had been speculated at the time,’ Smith said.

Keep reading

What happens when you clone a mouse for 58 generations?

In 2005, a husband-and-wife team at Japan’s RIKEN institute ran an experiment with a mouse: clone it, then clone the clone, then clone that clone, and keep going. Dr. Teruhiko Wakayama and Dr. Sayaka Wakayama kept it up for 20 years — through lab moves, a 2011 earthquake, and the pandemic — requiring 30,947 individual cloning attempts to produce 58 successive generations, as summarized by Metacelsus.

Things went smoothly for a while. An interim report in 2013 showed 25 healthy generations with no decline in cloning efficiency or mouse health. But mutations were quietly accumulating. By generation 57, the mice carried over 3,400 single-base DNA changes compared to the original — a mutation rate 3.1 times higher than natural reproduction in the same mouse strain. Sexually reproducing animals can shake off harmful mutations through recombination, where chromosomes shuffle and bad copies get discarded. Clones have no such mechanism, so every error sticks.

The bigger problems were structural. Somewhere between generations 25 and 45, an entire X chromosome vanished and never came back. Chromosomal deletions, inversions, and translocations piled up alongside the point mutations. By generation 58, the cells simply wouldn’t produce viable clones anymore, and the project ended. The mice that were born at every stage lived normal lifespans — the process didn’t produce sickly animals, just increasingly fragile DNA that eventually couldn’t survive the cloning procedure itself.

Keep reading

Oldest Dog DNA Ever Found Reveals How Ancient Our Friendship Really Is

The discovery of the oldest ever dog DNA suggests they have been our best friends for nearly 16,000 years – 5,000 years earlier than had previously been thought, new research said Wednesday.

Despite being ubiquitous in the homes, backyards and hearts of people across the world, surprisingly little is known about where dogs come from.

“It’s just an interesting mystery,” Swedish geneticist Pontus Skoglund of the UK’s Francis Crick Institute told reporters.

Dogs are most likely a mix of two types of grey wolves, he said. However exactly when dogs diverged from wolves has been difficult to trace, partly because their ancient bones are tricky to tell apart.

That is why scientists behind two new studies published in the journal Nature sequenced the genomes from archaeological remains, shedding light on the elusive origins of our furry friends.

The first study revealed that the world’s oldest canine DNA was discovered in a piece of a skull in Pinarbasi in what is now Turkey.

Keep reading

Modern humans arrived in Australia 60,000 years ago and may have interbred with archaic humans such as ‘hobbits’

A new study of nearly 2,500 genomes may have finally settled the debate about when modern humans arrived in Australia. Using a diverse database of DNA from ancient and contemporary Aboriginal people throughout Oceania, researchers have determined that people began to settle northern Australia by 60,000 years ago and that they arrived via two distinct routes.

Experts have long debated the date that humans first arrived in Australia, a feat that required the invention of watercraft. While some researchers have used genetic models to support a “short chronology” of 47,000 to 51,000 years ago for the arrival, others have marshaled archaeological evidence and Aboriginal knowledge in support of the “long chronology,” in which the first arrivals happened 60,000 to 65,000 years ago.

In the new study, published Friday (Nov. 28) in the journal Science Advances, researchers analyzed an “unprecedentedly large” dataset of 2,456 human genomes to answer the question of when humans journeyed from Sunda (the ancient landmass, also known as Sundaland, that included what are today Indonesia, the Philippines and the Malaysian Peninsula) to Sahul (a paleocontinent that included modern-day Australia, Tasmania and New Guinea).

Keep reading