Tag: human experimentation

The Urban Legend of the Government’s Mind-Controlling Arcade Game

IN A SUBURBAN ARCADE NEAR Portland, Oregon, in 1981, a dull, digital glow bounced off the faces of teenagers who clutched joysticks, immersed in the game. Tiny lines and dots danced or exploded with high-pitched beeps across them all, but one game cabinet, Polybius, drew the longest lines.

Gamers who tried it couldn’t stop playing, and began acting oddly: they were nauseous, stressed, had horrific nightmares. Others had seizures or attempted suicide, many felt unable to control their own thoughts. It was only later that they recalled how Polybius was serviced more often than other games. Men in black suits opened the machine every week, recorded its data, and left, with no interest in its coins. Soon after it appeared, the mysterious arcade game vanished without warning—taken by the men in black suits, leaving no record of its existence.

That’s the story, at least. This legend is one of the big unsolved mysteries of the gaming world, though most concede that the game never existed. It’s since become an urban legend on gaming and conspiracy websites and the internet horror wiki Creepypasta, and like all good stories, it is kept alive by its fans.  

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Startup aims to make lab-grown human eggs, transforming options for creating families

On a cloudy day on a gritty side street near the shore of San Francisco Bay, a young man answers the door at a low concrete building.

“I’m Matt Krisiloff. Nice to meet you,” says one of the founders of Conception, a biotech startup that is trying to do something audacious: revolutionize the way humans reproduce. “So let me find them real quick,” says Krisiloff as he turns to look for his co-founders, Pablo Hurtado and Bianka Seres, so they can explain Conception’s mission.

“I personally think what we’re doing will probably change many aspects of society as we know it,” says Hurtado, the company’s chief scientific officer. “It’s really exciting to be working on a technology that can change the lives of millions of humans.”

Conception is trying to accelerate, and eventually commercialize, a field of biomedical research known as in vitro gametogenesis (IVG). “Basically, we’re trying to turn a type of stem cell called an induced pluripotent stem cell into a human egg,” Krisiloff says. “[This] really opens the door, if you can create eggs, to be able to help people have children that otherwise don’t have options right now.”

The experimental technology could help women who have lost their eggs to cancer treatment, women who have never been able to produce healthy eggs and women whose eggs are no longer viable because of their age.

IVG would enable these women to have their own genetically related babies at any age. That’s because induced pluripotent stem cells can be made from just a single cell from anyone’s skin or blood. So these lab-grown eggs would have that person’s DNA.

But the possibilities are even broader.

“My personal biggest interest in it is it could allow same-sex couples to be able to have biological children together as well,” Krisiloff says. “Yeah, I’m gay, and it’s something that got me so personally interested in this in the first place.”

Same goes for Hurtado. “There is something intrinsic about sharing a life that is half me and half my husband. I don’t have that capacity right now.” He adds, “I am devoting my life to trying to change that.”

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Lab Administers A.I.-Designed Drug to First Patient

Hong Kong- and New York-based Insilico Medicine on Tuesday announced a drug for treating idiopathic pulmonary fibrosis (IPF) designed by generative artificial intelligence (A.I.) has advanced to Phase 2 clinical trials, which means the drug has been administered to its first human patient.

IPF is a chronic lung disease that makes it more difficult to breathe, starving the body of much-needed oxygen. IPF is currently regarded as incurable, but treatable. 

“Generative A.I.” is the level of artificial intelligence that can accept fairly broad commands from a human user and create a complex finished product. Such A.I. systems grow more powerful and useful as they “learn” by accumulating information. DALL-E, the computer art program that can fulfill instructions like “Show me what the Peanuts characters would look like if Picasso drew them” is a popular example.

Creating a new medicine is a daunting task. The design stage includes a great deal of labor-intensive research that could hopefully be completed more quickly by A.I.

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NEW DOCS LINK CIA TO MEDICAL TORTURE OF INDIGENOUS CHILDREN AND BLACK PRISONERS

The documentary record of “mind control” experiments conducted by the United States and other governments during the Cold War is just the tip of the iceberg, and our collective ignorance is by design. In early 1973, as the fallout from the Watergate scandal exposed the need for greater congressional oversight of U.S. intelligence agencies, the head of the Central Intelligence Agency (CIA) ordered the destruction of all documents related to MK Ultra.

Launched in the wake of the Nuremberg Trials, which exposed the extent of Nazi atrocities carried out in the name of science, MK Ultra involved a range of grotesque experiments on unwitting test subjects within and beyond U.S. borders. Newly revealed evidence exposes previously hidden links between MK Ultra experiments on Indigenous children in Canada and imprisoned Black people in the U.S.

On April 20, 2023, a group of Indigenous women known as the Kanien’kehà:ka Kahnistensera (Mohawk Mothers) achieved a milestone in their ongoing lawsuit against several entities, including McGill University, the Canadian government and the Royal Victoria Hospital in Quebec. The parties reached an agreement whereby archeologists and cultural monitors would begin the process of searching for unmarked graves, which the Mohawk Mothers believe are buried on the grounds of the hospital.

Over the preceding two years, approximately 1,300 unmarked graves, most of them containing the remains of Indigenous children, have been discovered on the grounds of five of Canada’s former residential schools. Throughout the 20th century, the residential school system — like the Indian Boarding School system, its U.S. counterpart — separated thousands of Indigenous children from their families, stripped them of their language and subjected them to various forms of abuse amounting to what a truth and reconciliation commission called “cultural genocide.” But as these horrific revelations demonstrate, the harm wasn’t only cultural — a 1907 investigation found that nearly one-fourth of school attendees did not survive graduation.

In October of 2021, new evidence surfaced linking disappeared Indigenous children to MK Ultra experiments conducted by CIA-sponsored researchers. A white Winnipeg resident named Lana Ponting testified in Quebec’s Superior Court that in 1958, when she was 16 years old, doctors from the Allan Memorial Institute, a former psychiatric hospital affiliated with McGill and the Royal Victoria Hospital, held her against her will, drugged her with LSD and other substances, subjected her to electroshock treatments, and exposed her to auditory indoctrination: playing a recording telling Ponting over and over again, that she was either “a bad girl” or “a good girl.”

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Synthetic human embryos are created in the lab with NO egg or sperm: Scientists announce historic breakthrough raising hopes for new treatments for miscarriage and rare genetical disorders – but development poses huge ethical dilemmas

Human embryos made without eggs or sperm have been created in a scientific breakthrough which is bound to raise serious ethical and legal questions.

They were produced in a joint project between Cambridge University and the California Institute of Technology and resemble embryos in the earliest stages of human development.

They do not have the beginnings of a brain or a beating heart, but do include cells which would go on to form the placenta and yolk sac.

Scientists believe that their finding could provide significant insight and aid research into rare genetic disorders and the biological causes of miscarriage.

But the synthetic embryos are not covered by laws in the UK or in most countries around the world, meaning that they come with serious ethical and legal issues regarding the use of human embryos in a lab.

Until this breakthrough, scientists had to adhere to the 14-day rule which meant they were limited to allowing embryos to develop in a lab for a maximum of two weeks.

After this point researchers would have to wait until further along its development to pick up their study, relying on pregnancy scans and embryos donated to research. 

The desire to understand this period of an embryo’s development – which starts at day 14 and ends around day 28 – was the main motivation behind the work to create synthetic human embryos.

Professor Magdalena Zernicka-Goetz, a fellow at the University of Cambridge, described the work yesterday at the International Society for Stem Cell Research’s annual meeting in Boston: ‘We can create human embryo-like models by the reprogramming of [embryonic stem] cells.’

Before the talk, she told The Guardian: ‘It’s beautiful and created entirely from embryonic stem cells.’

While it is not yet clear if the synthetic embryos could continue developing beyond their early stages, implanting them into a patient’s womb would be illegal and there is no near-term prospect of them being used for medical purposes.

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Elon Musk’s Neuralink Gets FDA Approval to Study Brain Implants in Humans

Elon Musks’s neurotechnology company Neuralink announced on Thursday it has obtained approval from the U.S. Food and Drug Administration (FDA) to carry out a clinical study of brain implants in humans.

It marks the first in-human clinical study for the company.

“This is the result of incredible work by the Neuralink team in close collaboration with the FDA and represents an important first step that will one day allow our technology to help many people,” the company said in a statement.

“Recruitment is not yet open for our clinical trial. We’ll announce more information on this soon!” it added, without providing further details about the trial.

Musk, in response, wrote on Twitter: “Congratulations Neuralink team!”

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Human-induced stem cells from Seattle now in space

Scientists are taking a deeper dive into the impacts of micro-gravity on the human body. Seattle’s Allen Institute is playing a key role in this experiment.

This particular mission,” Allen Institute for Cell Science scientist Brock Roberts said, “will provide yet another test for the fundamental capability of these stem cells.”

On Monday morning, SpaceX’s Falcon 9 rocket, carrying the Dragon Spacecraft with four Axiom-2 crewmembers inside, docked at the International Space Station (ISS). Also on that flight are human-induced pluripotent stem cells produced by scientists at the Allen Institute. This is the first time cells from the Allen Institute have traveled to space.

The Axiom-2 crew members will spend eight days at the ISS. The four astronauts will conduct scientific experiments, which include observing the effects of micro-gravity on cell growth and development.

The stem cells are capable of many amazing things they can differentiate into many different tissues,” Roberts said. “They can proliferate indefinitely without changing their fundamental character, but we don’t know a lot about their ability to exist and preform all of those fascinating phenomenon in space, we we will find out about that.”

The stem-cell study is part of a series of NASA-funded experiments led by researchers at Cedars-Sinai Medical Center in Los Angeles.

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Babies who have DNA from 3 different people born in the U.K.

Britain’s fertility regulator on Wednesday confirmed the births of the U.K.’s first babies created using an experimental technique combining DNA from three people, an effort to prevent the children from inheriting rare genetic diseases.

The Human Fertilization and Embryology Authority said fewer than five babies have been born this way in the U.K. but did not provide further details to protect the families’ identities. The news was first reported by the Guardian newspaper.

In 2015, the U.K. became the first country to adopt legislation regulating methods to help prevent women with faulty mitochondria — the energy source in a cell — from passing defects on to their babies. The world’s first baby born using the technique was reported in the U.S. in 2016.

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U.S. argues for immunity in MK-ULTRA mind control case before Quebec Court of Appeal

A proposed class-action lawsuit over infamous brainwashing experiments at a Montreal psychiatric hospital was before Quebec’s highest court Thursday, as victims attempted to remove immunity granted to the United States government.

The U.S. government successfully argued in Quebec Superior Court last August that the country couldn’t be sued for the project known as MK-ULTRA, allegedly funded by the Canadian government and the CIA.

U.S. lawyers argued that foreign states had absolute immunity from lawsuits in Canada between the 1940s and 1960s, when the program took place.

But survivors (and their families) of the experiments at Montreal’s Allan Memorial Institute — which included experimental drugs, rounds of electroshocks and sleep deprivation — appealed that decision.

On Thursday, a lawyer representing the United States government told the Quebec Court of Appeal that the country should be immune from prosecution and that any lawsuit against the U.S. government should be filed in that country.

The court case stems from a class-action lawsuit filed against McGill University — which was affiliated to the psychiatric hospital — Montreal’s Royal Victoria Hospital and the Canadian and U.S. governments after Montrealers allegedly had their memories erased and were reduced to childlike states.

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Scientist who edited babies’ genes says he acted ‘too quickly’

The scientist at the heart of the scandal involving the world’s first gene-edited babies has said he moved “too quickly” by pressing ahead with the procedure.

He Jiankui sent shock waves across the world of science when he announced in 2018 that he had edited the genes of twin girls, Lulu and Nana, before birth. He was subsequently sacked by his university in Shenzhen, received a three-year prison sentence, and was broadly condemned for having gone ahead with the risky, ethically contentious and medically unjustified procedure with inadequate consent from the families involved.

Speaking to the Guardian in one of his first interviews since his public re-emergence last year, He said: “I’ve been thinking about what I’ve done in the past for a long time. To summarise it up in one sentence: I did it too quickly.”

However, he stopped short of expressing regret or apologising, saying “I need more time to think about that” and “that’s a complicated question”.

He declined to elaborate on what he believed ought to have been in place before proceeding with gene editing, but said he would give further details at an invited talk he is scheduled to give at the University of Oxford next month.

He studied physics in China before moving to the US to study for a PhD at Rice University and a post-doctorate in genome sequencing at Stanford University. He returned to China in 2012 to pursue Crispr-Cas9 gene-editing research, launching a variety of biotechnology business ventures.

Gene-edited cells were already beginning to be used in clinical treatments for adults. But genetically modifying embryos was – and is – far more ethically contentious, because changes are made to every cell in the body and are passed down to subsequent generations. Some question whether such a step could ever be medically justified.

Against this backdrop, He dropped the bombshell at an international conference in Hong Kong four years ago that he had modified two embryos before they were placed in their mother’s womb. It later emerged that a third gene-edited baby had been born.

The edit, of a gene called CCR5, targeted a pathway used by the HIV virus to enter cells, and was claimed to give the babies immunity to HIV.

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