Study: CBD Inhibits Osteosarcoma by Targeting Tumor-Driving Inflammation

“Osteosarcoma remains a therapeutic challenge due to its aggressive behavior and high metastatic potential, necessitating exploration of novel treatment modalities”, states the study’s abstract. “Cannabidiol (CBD), a non-psychoactive phytocannabinoid with emerging anticancer properties, has shown promise in preclinical cancer models. However, its mechanisms of action in osteosarcoma remain incompletely understood.”

With that in mind, “This study systematically investigates the antitumor effects of CBD on osteosarcoma and elucidates its molecular targets within the TNF-α/NF-κB/CCL5 signaling axis.”

Conducted by researchers at Shandong University and Harbin Medical University, researchers used cell-based assays and a mouse model, finding that CBD suppressed osteosarcoma cell proliferation, migration, and invasion, while also reducing tumor growth in vivo.

The team identified that CBD binds directly to the NF-κB subunit p65, blocking its ability to activate transcription of the chemokine CCL5. This disruption also interfered with a previously unrecognized positive feedback loop between p65 and CCL5, which helps sustain inflammatory signaling in osteosarcoma cells. By targeting this loop, CBD not only inhibited tumor-promoting inflammation but also weakened the cancer’s ability to proliferate and spread.

The researchers used a combination of molecular docking, protein-binding assays, and gene expression analysis to confirm CBD’s direct interaction with the p65 protein and its downstream effects.

Keep reading

The Biggest Sun Myth Ever Told

Everything you’ve been told about skin cancer and the sun is a lie.

Outdoor workers get 3–10 times MORE sun exposure yet have LOWER melanoma rates than those stuck inside.

It gets worse.

A 20-year Swedish study found that avoiding sunlight raised the risk of premature death by 60%, especially from heart disease and cancer.

They pushed sunscreen and fear while ignoring the simple truth that sun exposure mostly causes HARMLESS cancers, while sun avoidance is linked to the DEADLIEST ones.

Get ready to be re-educated about the sun. It’s time to unlearn the lies you’ve been sold.

Ever wonder why you were told to hide from the sun?

It was never about your health.

Sunlight regulates circadian rhythms, lifts your mood, drives blood flow, and lowers your risk of dying.

And yet dermatology declared war on it—turning life-giving light into a deadly threat while skin cancer diagnoses soared.

Keep reading

Pharoah’s Curse Fungus Yields Breakthrough in Blood Cancer Treatment

In a stunning discovery, researchers at the University of Pennsylvania have harnessed a deadly fungus, once blamed for the “Pharaoh’s Curse,” to develop a promising new treatment for blood cancer.

This breakthrough, rooted in a toxin produced by the Aspergillus flavus mold, could offer hope to patients battling leukemia.

The story begins in the 1920s, when famed archaeologist Howard Carter opened King Tutankhamun’s tomb, an event followed by the mysterious deaths of eight team members. Whispers of a “Pharaoh’s Curse” spread, but medical experts suspected a fungal culprit.

Decades later, the excavation of King Casimir IV of Poland’s tomb in the 1970s confirmed these suspicions. Four of twelve archaeologists died within weeks, and investigators pinpointed Aspergillus flavus, a highly toxic fungus, as the cause. This mold produces asperigimycin, a toxin lethal to lung tissue but now showing remarkable potential in cancer research.

The University of Pennsylvania team discovered that asperigimycin is exceptionally effective at destroying leukemia cells in lab tests. However, the toxin required modification to become a viable cancer therapy.

Using a cutting-edge technique known as ribosomally synthesized and post-translationally modified peptides (RiPPs), the researchers engineered asperigimycin peptides.

Keep reading

Toxic Fallout: NC Lawmakers Face Fire Over Monsanto ‘Get-Out-Of-Jail-Free’ Provision

In a move that has ignited fierce backlash, North Carolina lawmakers attempted a “gut and stuff.” By inserting a last-minute “de facto immunity provision” into an unrelated House bill, agrochemical giants like Monsanto-Bayer will be given a free pass from accountability for its products linked to cancer and infertility, depending on what happens next. 

A highly controversial policy, Monsanto-Bayer has been seeking state level labeling exemptions amid bankruptcy exploration, as the company faces over 67,000 lawsuits nationwide for its product Round Up.

The revelation, brought to light by molecular toxicologist Dr. Alexandra Muñoz, set off alarm bells among health advocates and concerned citizens alike, who quickly lit-up the phone lines. 

Keep reading

SARS-CoV-2 Vaccination and the Multi-Hit Hypothesis of Oncogenesis

Cancer is a complex and dynamic disease. The “hallmarks of cancer” were proposed by Hanahan and Weinberg (2000) as a group of biological competencies that human cells attain as they progress from normalcy to neoplastic transformation. These competencies include self-sufficiency in proliferative signaling, insensitivity to growth-suppressive signals and immune surveillance, the ability to evade cell death, enabling replicative immortality, reprogramming energy metabolism, inducing angiogenesis, and activating tissue invasion and metastasis. Underlying these competencies are genome instability, which expedites their acquisition, and inflammation, which fosters their function(s). Additionally, cancer exhibits another dimension of complexity: a heterogeneous repertoire of infiltrating and resident host cells, secreted factors, and extracellular matrix, known as the tumor microenvironment, that through a dynamic and reciprocal relationship with cancer cells supports immortality, local invasion, and metastatic dissemination. This staggering intricacy calls for caution when advising all people with cancer (or a previous history of cancer) to receive the COVID-19 primary vaccine series plus additional booster doses. Moreover, because these patients were not included in the pivotal clinical trials, considerable uncertainty remains regarding vaccine efficacy, safety, and the risk of interactions with anticancer therapies, which could reduce the value and innocuity of either medical treatment.

After reviewing the available literature, we are particularly concerned that certain COVID-19 vaccines may generate a pro-tumorigenic milieu (i.e., a specific environment that could lead to neoplastic transformation) that predisposes some (stable) oncologic patients and survivors to cancer progression, recurrence, and/or metastasis. This hypothesis is based on biological plausibility and fulfillment of the multi-hit hypothesis of oncogenesis (i.e., induction of lymphopenia and inflammation, downregulation of angiotensin-converting enzyme 2 (ACE2) expression, activation of oncogenic cascades, sequestration of tumor suppressor proteins, dysregulation of the RNA-G quadruplex-protein binding system, alteration of type I interferon responses, unsilencing of retrotransposable elements, etc.) together with growing evidence and safety reports filed to Vaccine Adverse Effects Report System (VAERS) suggesting that some cancer patients experienced disease exacerbation or recurrence following COVID-19 vaccination. In light of the above and because some of these concerns (i.e., alteration of oncogenic pathways, promotion of inflammatory cascades, and dysregulation of the renin-angiotensin system) also apply to cancer patients infected with SARS-CoV-2, we encourage the scientific and medical community to urgently evaluate the impact of both COVID-19 and COVID-19 vaccination on cancer biology and tumor registries, adjusting public health recommendations accordingly.

Keep reading

17 Ways mRNA Shots May Be Fueling Cancer, Backed by Over 100 Studies

A comprehensive literature review by Mathilde Debord titled “COVID-19 mRNA vaccines can induce cancer in 17 distinct ways, according to over 100 studies was just published in Le Point Critique.

Drawing from over 100 peer-reviewed studies, it outlines 17 distinct biological mechanisms by which the injections may initiate, accelerate, or reactivate malignant processes.

1. Genome Instability

mRNA may be reverse-transcribed and integrated into host DNA, triggering mutations that initiate cancer.

2. Immune Escape

The spike protein binds and inhibits tumor suppressor genes like p53 and BRCA1, shielding cancer cells from immune destruction.

3. Impaired DNA Repair Mechanism

The spike protein interferes with essential DNA repair enzymes, increasing the risk of unchecked mutations.

4. Chronic Inflammation

Lipid nanoparticles and spike protein cause long-lasting inflammation, a well-known driver of cancer.

5. Dysregulation of the Immune System

Suppression of T cells and type I interferon weakens cancer surveillance and promotes immune evasion.

6. RNA Disruption

Codon optimization disrupts microRNA networks, destabilizing cell growth regulation and apoptosis.

7. Activation of Oncogenic Pathways

The spike protein indirectly activates MAPK and PI3K/mTOR signaling, fueling tumor growth and metastasis.

8. Tumor Microenvironment Alteration

Lipid nanoparticles accumulate in tumors, enhancing permeability and potentially accelerating cancer spread.

9. Awakening Dormant Cancers

Post-vaccination inflammation and immune disruption may trigger recurrence in patients previously in remission.

10. Alteration of Immune Surveillance

Modified mRNA blocks toll-like receptors, making tumor cells “invisible” to the immune system.

Keep reading

TURBO CANCER UPDATE: A Forgotten Cancer Is Surging in Young People, And Experts Are “Puzzled”

As this Substack has been warning for many years now, the turbo cancer epidemic is only now getting underway as a direct function of the Modified mRNA slow kill bioweapon “vaccine” platform that was foisted on humanity during the PSYOP-19 scamdemic; in other words, cancer rates will continue to explode, and the genetically modified young people will be …

Read full story

…which brings up to a recent article in Science Alert entitled, A Forgotten Cancer Is Surging in Young People, And Experts Are Puzzled, and the horrifying implications of what is transpiring all around us:

Appendix cancer is a condition that, until recently, was so rare that most people never gave it a second thought.

For decades, it was the kind of disease that doctors might encounter only once or twice in a career, and it was almost always found in older adults.

So this appendix turbo cancer was exceedingly rare even in adults, which makes the following absolutely incontrovertibly a direct result of these Modified mRNA poisons:

But now a surprising and concerning trend is emerging: appendix cancer is being diagnosed more often, and it’s increasingly affecting people in their 30s, 40s and even younger. This shift has left many experts puzzled and searching for answers.

The appendix is a small, finger-shaped pouch attached to the large intestine. Its purpose in the body is still debated, but it’s best known for causing appendicitis, a painful inflammation that often requires emergency surgery. What’s less well known is that cancer can develop in the appendix, usually without any warning signs.

And just like how even children are now suffering from premature Alzheimer’s Disease due to the “vaccines” causing prion-based diseases at any age, with amyloid fibrils now being found in 3-year-olds after in-utero mRNA injection exposure, we are seeing young people that never come down with appendix cancer currently being afflicted with this rarest of rare diseases:

new study, published in Annals of Internal Medicine, has shown that the number of appendix cancer cases has increased dramatically among people born after the 1970s. In fact, the incidence has tripled or even quadrupled in younger generations compared with those born in the 1940s.

The article then went into the usual feigned ignorance, because “experts” that poisoned humanity are always “puzzled” and “baffled” and “mystified” and “perplexed” by the most painfully obvious causes, which in turn implicates them in the crimes against humanity that they are ultimately guilty of due to aggressively pushing an Emergency Use Authorization (EUA) gene modifying “medical intervention” for demographics that have an Infection Fatality Rate (IFR) of around zero while openly admitting that said “vaccine” does nothing to stop transmission or attenuate symptoms:

So, what’s behind this surge? No one knows for sure, but one of the first suspects is the dramatic change in lifestyle and environment over the past several decades. Obesity rates have soared since the 1970s, and being overweight is a known risk factor for many cancers, including those of the digestive system.

Actually, everyone with a pair of neurons to rub together knows, but the “experts” will refuse to admit the grim truth, for now…

Keep reading

Some Jolly Rancher sweets unsafe to eat, FSA says

A number of products from a brand of US sweets are “unsafe to eat” and contain ingredients which could damage DNA and increase the risk of cancer, the Food Standards Agency (FSA) has warned.

UK businesses and consumers are being urged to stop buying and selling the Jolly Ranchers products, owned by US company Hershey.

The FSA says they contain chemical compounds – mineral oil aromatic hydrocarbons (MOAH) and mineral oil saturated hydrocarbons (MOSH) – which are “not compliant with UK laws”.

The products pose a safety risk if consumed regularly over time but there is “no immediate cause for concern, as [the] food safety risk is low”, the agency adds.

In a food alert published on Wednesday evening, the FSA said: “MOAH can cause damage to DNA and has the potential to increase the risk of cancer, particularly if consumed in high quantities over a prolonged period of time.

“MOAH is a genotoxic carcinogen, therefore no exposure is without risk to human health.”

MOAH and MOSH are used in confectionery to prevent stickiness and create a glossy appearance.

According to the agency, The Hershey Company has been working with the UK government body to remove the affected Jolly Rancher products from the UK market since 2024, but some businesses in Britain have continued to import the products.

Keep reading

mRNA Shots Induce Cancer-Linked Bone Marrow Reprogramming Within Weeks

The study titled, Metabolomic Profiling of Leukemic Hematopoiesis: Effects of BNT162b2 mRNA COVID-19 Vaccine Administrationwas just published in Current Molecular Medicine.

Researchers analyzed bone marrow samples from three groups using untargeted metabolomics, a powerful technique that detects thousands of small molecules reflecting real-time cellular activity:

  1. Vaccinated leukemia patients (n=7) — all of whom developed leukemia within 15 to 63 days after receiving Pfizer’s BNT162b2 COVID-19 mRNA injection
  2. Unvaccinated leukemia patients with no history of COVID-19 (n=2)
  3. Healthy, unvaccinated individuals (n=7)

Here’s what they found:

As expected, the metabolic profiles of both leukemia groups were markedly different from healthy controls—showing classic cancer-linked changes like:

  • ↑ Glycolysis (sugar breakdown)
  • ↑ Pentose phosphate pathway (nucleotide synthesis and redox balance)
  • Altered tryptophan metabolism, known to create an immunosuppressive tumor environment
  • Disrupted heme metabolism, involved in red blood cell formation and oxidative stress

However, the vaccinated leukemia group showed additional, distinct metabolic alterations that were not present in unvaccinated leukemia patients, including:

  • ↑ Tetrahydrofolic acid — vital for DNA synthesis, repair, and methylation. Uniquely elevated in vaccinated leukemia patients, possibly reflecting folate cycle modulation or compensatory changes in nucleotide metabolism.
  • ↑ Phosphorylcholine — a marker of altered membrane metabolism, linked to tumor progression, lipid signaling, and immune activation. Elevated only in vaccinated leukemia patients, contrasting with a decrease in unvaccinated leukemia cases.
  • ↑ N-Formyl-L-glutamic acid / N-Acetyl-L-aspartic acid — involved in amino acid and mitochondrial metabolism. Significantly elevated in vaccinated leukemia patients, not seen in unvaccinated leukemia individuals.
  • ↑ Delta 8.14-Sterol — a sterol lipid involved in membrane structure and cellular signaling. Increased only in the vaccinated leukemia group, potentially indicating vaccine-induced disruption of lipid regulation.

All seven vaccinated leukemia patients developed cancer within two months of mRNA injection.

Keep reading

Biden White House insisted families were safe after toxic East Palestine derailment — but behind the scenes, admin warned of ‘cancer cluster’

The Biden administration admitted possible cancer-causing toxins were spread in East Palestine, Ohio, following the Norfolk Southern train derailment in 2023, explosive new emails show, despite the White House insisting residents were safe.

“The occurrence of a cancer-cluster in EP [East Palestine] is not zero,” FEMA recovery leader James McPherson wrote in a March 29, 2024, email to other public health officials — a little more than a year after the crash.

“As you all are aware, the first 48 hours of the fire created a really toxic plume,” he said in the chain of communications, which were first reported by News Nation.

Just two months earlier, President Biden had excoriated “multimillion-dollar railroad companies transporting toxic chemicals” for the fiasco — but praised his administration’s “herculean efforts” to resolve the “vast majority” of East Palestine’s problems.

The crash spewed harmful chemicals into the air and resulted in 115,000 gallons’ worth of carcinogenic vinyl chloride undergoing an open burn — displacing residents and leading to reports of strange illnesses as well as the death of livestock in the weeks following the Feb. 3, 2023, disaster.

Keep reading