Researchers in Japan and the United States have found that ivermectin, a drug used to kill parasites, suppresses tumour development in epithelial ovarian cancer.
Ivermectin exerts an anti-tumour effect on epithelial ovarian cancer (EOC) cells by interacting with the new gene target KPNB1. Because ivermectin is already approved to treat parasitic infections in patients, experiments for its effectiveness in an anti-cancer regimen is expected to significantly lower costs compared to untested drug compounds.
“EOC is a challenging disease to treat because of its heterogeneity. The mortality rate has stayed steady for decades. We need new drugs and also new drug targets,” said Osaka University Gynecologist Michiko Kodama.
Uğur Şahin and Özlem Türeci, the husband and wife team who founded German pharma firm BioNTech, were studying a potential vaccine for tumors using a novel technology known as messenger RNA (mRNA) when they learned about a new type of coronavirus spreading in China in January 2020.
The couple decided to investigate the possibility of making a vaccine for that mysterious and highly contagious virus using mRNA. Within weeks, BioNTech scientists developed an experimental vaccine in partnership with American pharma giant Pfizer. And 10 months later, the vaccine cleared clinical trials and regulatory hurdles and began going into tens of millions of people’s arms around the world.
For Şahin and Türeci, it’s time to pick up the cancer research where it’s left.
“We have several different cancer vaccines based on mRNA,” Türeci told The Associated Press in an interview on Friday. Though it’s too early to predict when such a vaccine will be available, the prospect is promising. “It’s very difficult to predict in innovative development. But we expect that within only a couple of years,” Türeci added.
The biotech community has been studying mRNA for two decades. The medical platform works by carrying instructions for making antigen proteins found on the surface of a virus into body cells. The antigen will then be copied and produced in more cells to prime the immune system against that specific virus.