Tag: big pharma

Alzheimer’s Drugs Have No ‘Meaningful Effect’ on Cognitive Decline: Review

A class of Alzheimer’s drugs that have only been available for several years did not appear to have any “clinically meaningful effects,” according to a new review of clinical trial data.

Monoclonal antibodies that target plaque called amyloid beta in the brain showed little impact across 17 trials, Francesco Nonino, a neurologist and epidemiologist who directs the Unit of Epidemiology and Statistics at the IRCCS Institute of Neurological Sciences of Bologna, Italy, and co-authors wrote in the review.

“The effect of amyloid‐beta‐targeting monoclonal antibodies on cognitive function and dementia severity at 18 months in people with mild cognitive impairment or mild dementia due to Alzheimer’s disease is trivial, while on functional ability, it is small at best,” they said.

“Successful removal of amyloid from the brain does not seem to be associated with clinically meaningful effects in people with mild cognitive impairment or mild dementia due to Alzheimer’s disease. Future research on disease‐modifying treatments for Alzheimer’s disease should focus on other mechanisms of action,” they added later.

The review covered 17 studies involving 20,342 participants. The drugs were typically compared with placebos in the trials, which were all funded by pharmaceutical companies.

The monoclonal antibodies in question were first approved by the U.S. Food and Drug Administration in 2021. They include Lecanemab, which is available in the United States and other countries and is produced by Eisai and Biogen, and Eli Lilly’s Donanemab.

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FDA Calls On Drug Companies to Release Missing Clinical Trial Data

The Food and Drug Administration is urging pharmaceutical companies to make public data from clinical trials.

About three in 10 studies deemed highly likely to fall under mandatory reporting requirements have no results filed with the government’s clinical trial website, the FDA said on April 13. That is in line with historical estimates.

The FDA sent more than 2,200 companies and researchers messages in late March that reminded them of the requirements, the agency said on April 13.

“Far too often, companies are suppressing unfavorable clinical trial results and keeping them secret from patients and the scientific community. Those sponsoring clinical trials have an ethical obligation to make results public regardless of the data’s influence on the company’s share price,” FDA Commissioner Dr. Marty Makary said in a statement.

“Too many clinical trial sponsors and researchers are failing to report their results, leaving important information unavailable to clinicians and other researchers. If you are a doctor deciding whether or not to prescribe a medication to a patient, you deserve to have the best data about clinical studies on that medication.”

Sponsors of many clinical trials, and researchers involved with them, are required by federal law to report at least a summary of results within one year of completion. Phase 1 trials are among those excluded from the requirements.

The FDA can initiate a process when the people responsible for submitting the information fail to do so, which can lead to fines of up to $10,000. The process includes sending notices of noncompliance.

Only two such notices were sent in 2025, and the agency is declining to issue any, at least for now.

“The messages issued on March 30, 2026, represent an extra step the agency is taking to provide the relevant responsible parties with the opportunity to comply with federal law before the agency considers whether to take further regulatory action,” the FDA stated.

The agency, under Makary, has favored pressing companies to voluntarily meet its demands, including the removal of synthetic dyes from food.

“I fully support this new initiative to increase the prompt publication—as required by law—of results information from interventional studies of the medical products we regulate,” Dr. Tracy Beth Hoeg, acting director of the FDA’s Center for Drug Evaluation and Research, said in a statement.

“We hope that the thousands of messages sent to sponsors and investigators reminding them to publicly report their findings will improve patient safety and keep researchers and the public better informed of benefits and risks of new and investigational products.”

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Pro-Vaccine Panelists: ‘We’re Losing the PR and Communications Battle’

The medical industry is losing control of the vaccine narrative, according to participants in a webinar moderated by Chelsea Clinton and organized by Unity Consortium — a group of pharmaceutical companies and pro-vaccine organizations.

Vaccine makers GSK, Merck and Sanofi, along with Big Tech platforms Reddit and Snapchat, and Spanish-language media giant Televisa Univision sponsored Wednesday’s event: “Who Influences Young People’s Health Choices? The New Conversations About Vaccines.”

Unity Consortium lists Pfizer, Merck, GSK and Sanofi among its members. Vaccine inventor Dr. Paul Offit is a member of its board of directors.

During the hour-long conversation, Clinton and the panelists criticized the growing number of parents and teens who are starting to question the safety of vaccines. They blamed the trend on increased access to what they characterized as online “misinformation” — and on organizations like Children’s Health Defense (CHD).

“What’s different today … is that people have access to a lot more information,” said Dr. Margot Savoy, chief medical officer of the American Academy of Family Physicians. “The part that makes me nervous is that, more and more, we’re getting into this odd space where people are feeling a little more polarized.”

Jessica Steier, founder and CEO of Unbiased Science and author of “The Playbook Used to ‘Prove’ Vaccines Cause Autism,” said pro-vaccine voices are “losing the PR and communications battle.”

Elisabeth Marnik, Ph.D., executive director of The Evidence Collective and author of “I Grew Up Unvaccinated. Now I’m an Immunologist,” said the circulation of and public access to such information is “one of the hardest parts about social media.”

“The more somebody sees these false claims circulating, the more likely they are to start to question their own understanding. And that’s one of the dangers of social media,” Marnik said. She said that parents’ decisions not to vaccinate their children are “a product of [this] information ecosystem.”

Clinton suggested that the ecosystem acts as a barrier to sustaining trust in the medical profession and public health. “The algorithms are part of the challenge of both … the corrosion of trust and … the barriers to replenishing and sustaining that trust,” Clinton said.

According to Marnik, the public health establishment is losing public trust because “public health and science aren’t always good storytellers.” The “anti-vaccine side” is “really good at spreading these stories that are really compelling and very scary and [that] can motivate people in ways that are harmful.”

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New York Times does it again, pushing pro-vaccine narrative over journalism

A recent New York Times article examining Robert F. Kennedy Jr. and developments at the CDC is drawing criticism over what some describe as one-sided vaccine coverage.

The article, published March 23, relied heavily on interviews with former CDC officials and presented commonly cited claims that vaccines are safe and effective, while offering little perspective from those who question that view.

It also highlighted Kennedy’s work and advocacy, including claims that he has spread misinformation about vaccines.

The coverage pointed to a 2025 measles outbreak in a Texas community with low vaccination rates, attributing reported deaths to measles. Other accounts cited by Children’s Health Defense have raised questions about those conclusions.

The article also addressed statements about vaccine ingredients, including the use of fetal cell lines in some vaccines. Kennedy has raised concerns about the presence of human DNA fragments, which some individuals cite as a religious or ethical issue.

On autism, the article echoed the widely held view that rising diagnosis rates are largely due to expanded screening and reporting. Critics argue that explanation does not fully account for the increase.

The article further referenced concerns about what it described as “spurious harms” linked to vaccines. However, federal data show billions of dollars have been awarded through the vaccine injury compensation program.

It also cited public health positions on issues such as fluoridated drinking water and routine vaccination schedules recommended by major medical organizations.

The broader debate over vaccine mandates and informed consent was also raised, including whether individuals should have the right to decline vaccines for religious or personal reasons.

The discussion comes as vaccination rates for some vaccines have declined, religious exemptions have increased, and lawmakers consider changes to vaccine policy, including liability protections and exemption laws.

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End of Federal Childhood Vaccine Incentives

Doctors will no longer receive financial rewards tied to childhood vaccination rates under key government programs. The announcement, first detailed in a December 30 memo from the Centers for Medicare & Medicaid Services (CMS), states that the agency “does not tie payment to performance on immunization quality measures in Medicaid and CHIP [the Children’s Health Insurance Program] at the federal level.” CMS urged states to discontinue similar incentives and eliminated mandatory reporting of childhood immunization data, though voluntary reporting remains an option. The memo also signaled efforts to strengthen informed consent and accommodate religious exemptions.

U.S. Health and Human Services Secretary Robert F. Kennedy, Jr. welcomed the directive, posting: “Government bureaucracies should never coerce doctors or families into accepting vaccines or penalize physicians for respecting patient choice. That practice ends now.” Advocates such as Children’s Health Defense CEO Mary Holland called it a welcome step toward treating vaccines like other medical interventions, free from metric-driven pressure. Pediatrician Dr. Michelle Perro noted that tying compensation to specific decisions can erode trust in care.

Promoting Preventive Care or Distorting Judgment?

This change comes after years of scrutiny over financial incentives in pediatric medicine. An October 2025 clip from Dr. Suzanne Humphries on The Joe Rogan Experience claimed some doctors could lose up to $250,000 annually by not meeting vaccination targets, including for Covid shots in infants. These incentives stemmed from value-based payment models under Medicaid, CHIP, and private insurers. Practices received bonuses or higher reimbursements for hitting coverage benchmarks (e.g., percentages of patients vaccinated). One analysis of an Oregon pediatric practice projected more than $1 million in annual losses for declining CDC-scheduled vaccines, largely from administrative fees. Roughly 40 percent of U.S. children are on Medicaid, amplifying the program’s reach. During Covid, specific per-dose payments (around $45 plus administration fees) added to the structure.

Proponents of the incentives argued they promoted preventive care and reduced disease outbreaks, with insurers — not pharmaceutical companies — providing payments to lower long-term costs. Critics, however, contended the metrics distorted clinical judgment and pressured families, contributing to eroded trust and reports of patients being dismissed for declining shots.

The CMS policy applies only at the federal level; some states or private insurers may retain incentives. It is telling that pediatric organizations are pushing back against broader vaccine-policy shifts under the current administration.

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Vaccine Amnesia: Why Did The Media Stop Covering Vaccine Disasters?

A key theme I’ve tried to highlight in this publication is that the same medical catastrophes keep repeating (because those responsible are never held accountable), so by understanding what happened in the past, you can see and understand what is happening now and what will likely happen in the future.

For example, because vaccines are “risky but necessary,” the medical profession and government, again and again, concluded that they needed to tell the public all vaccines were “safe and effective” as the potential injuries a mass vaccination campaign would cause were outweighed by “necessary” benefit the vaccines could offer. As such, examples can be found again and again of severe injuries being systematically covered up for the “greater good” (e.g., the earliest documented example I know of this happened in 1874 with the smallpox vaccine) and health authorities concocting the same set of excuses we’ve seen since smallpox as to why those vaccines failed to prevent the diseases they were supposed to.

Since the risks outweigh the benefits for most vaccines (detailed here), a mass vaccination paradigm can only be sustained by censoring all evidence of harm, and then using that absence of evidence as proof the vaccines are safe. As such, over the decades, we’ve seen more and more be done to conceal those harms.

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FDA Grants Speedy Approval to Eli Lilly’s Weight-Loss Pill for Obesity

Federal regulators on Wednesday approved Eli Lilly’s new weight-loss pill, a second daily oral medication to treat obesity and other weight-related conditions.

The Food and Drug Administration granted expedited approval to orforglipron, a GLP-1 drug that works like widely used injectable medications to mimic a natural hormone that controls appetite and feelings of fullness.

The drug, which will be branded as Foundayo, is expected to begin shipping Monday. The company said people with insurance may be able to get the drug starting at $25 per month with a Lilly discount card. Prices for people paying cash will range between $149 per month to $349 per month, depending on the dose.

The new pill joins drugmaker Novo Nordisk’s oral Wegovy pill, which has spurred more than 600,000 prescriptions in the United States since it was approved in December.

The FDA authorized Eli Lilly’s drug as part of a new program aimed at cutting drug approval times. The agency said it reviewed the company’s application in 50 days.

In a clinical trial of more than 3,000 adults with obesity, participants who received the highest dose of orforglipron, 36 milligrams, lost 11.2% of their body weight — about 25 pounds on average — over more than 16 months. That compared with a 2.1% weight loss, or less than 5 pounds, in patients who received a placebo, or dummy pill, according to the New England Journal of Medicine.

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Big Pharma Giants Pfizer and BioNTech Forced to Shut Down COVID-19 Booster Shot Trials After Americans Refuse to Be Guinea Pigs

Major Big Pharma companies have abruptly halted their latest COVID-19 mRNA “booster” trial because they literally couldn’t find enough willing participants.

After years of gaslighting the American public, raking in hundreds of billions in profits from experimental shots that were shoved down our throats under the guise of “public health,” the same corporations that partnered with the Biden regime, Anthony Fauci, and the lying mainstream media are now facing the cold, hard reality: Americans are done being lab rats.

According to internal letters sent to trial investigators and obtained by Reuters, Pfizer is ending its study of “updated” shots in healthy adults aged 50 to 64.

The company admitted it was “unable to generate relevant data” because recruitment had effectively hit a brick wall.

Reports indicate that more than 80% of potential recruits didn’t even make it past pre-screening, or simply refused to participate.

The trial, which aimed to enroll a massive 25,000 to 30,000 participants, folded after failing to meet even the most basic enrollment targets.

This comes at a time when the “science” is being scrutinized like never before. Under the current administration, the FDA has been pressured to actually require randomized placebo-controlled trials, the very thing skeptics have been demanding for years.

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FDA Warns of Deaths Linked to Drug It Wants Removed From Market

The Food and Drug Administration said in a March 31 alert that it has learned of eight deaths linked to a drug called avacopan that is used to treat blood vessel inflammation.

A review of studies, documents from avacopan manufacturer Amgen, and reports to the FDA’s adverse event reporting system resulted in the identification of 76 cases of drug-induced liver injury “with reasonable evidence of a causal association with avacopan use,” the FDA said in a drug safety alert.

Fifty-four of the cases led to hospitalization, and eight ended in death.

Some of the cases involved a syndrome that features the destruction of bile ducts in the liver, which can lead to permanent liver damage.

“Patients should contact their health care professional immediately if they develop any signs or symptoms that may indicate liver injury, such as: feeling more tired than usual; nausea; vomiting; unusual itching; light-colored stools; yellowing of skin or eyes; dark urine; swelling in the stomach or abdomen; or pain in the right upper abdomen,” the FDA stated. “Patients should talk to their health care professional about the safety risks associated with Tavneos and whether to continue therapy or switch to alternative treatments.”

Avacopan, also known as Tavneos, was approved by the FDA in 2021 for the treatment of severe active anti-neutrophil cytoplasmic autoantibody-associated vasculitis, or blood vessel inflammation.

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The American Mind Has Collapsed: How Vaccine Damage and Tribal Stupidity Created a Nation of Gullible Fools

How Mainstream America Became Dumb… and then Dumber

I’ve spent years observing, documenting, and sounding the alarm about the erosion of American intelligence and discernment. Today, I believe we are witnessing not just a cultural or political decline, but a mass cognitive collapse — a deliberate, engineered stupidity that has rendered a once-critical populace into a nation of gullible fools.

This is not an accident. It is the culmination of a multi-front war on human cognition, waged through toxic vaccines, processed food poisons, electromagnetic pollution, and a relentless propaganda machine that celebrates mediocrity and punishes truth. The evidence is everywhere, from the halls of government to the checkout line at the grocery store. We have crossed a cognitive event horizon, and the path back to reason seems all but lost [1]. Here’s how we got here, and why it matters for the survival of freedom itself.

The Unprecedented Decline of American Intelligence

The data is in, and it’s grim. Across all ages and demographics, test results show Americans are getting dumber [2]. This isn’t a minor dip in scores; it’s a systemic plunge. I believe this mass cognitive decline is largely driven by physical and chemical assaults on the brain, with vaccine damage playing a central role. The adjuvants in vaccines, particularly aluminum, are a silent, pervasive threat [3]. Studies have found high aluminum levels in patients with Alzheimer’s, autism, and epilepsy, and this neurotoxic substance is directly injected into the population, especially infants [3].

Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction [4]. This is not speculation; it is documented science that the corrupt medical establishment desperately wants you to ignore. When you combine this with the brain-damaging effects of other environmental toxins like lead [5], glyphosate in food, and electromagnetic fields from 5G, you have a perfect storm for neurological decay. The once-critical American mind, capable of innovation and self-governance, has been replaced with a gullible, tribalistic stupidity that I find unprecedented in our history. We are becoming a population of psychological zombies, primed to believe anything our tribal leaders tell us [6].

The Artemis Moon Farce: A Case Study in Celebrating Nothing

Nothing exemplifies this collapse of basic reasoning more than the public’s reaction to NASA’s Artemis program. Celebrating a flight that’s merely planned to go around the moon as “going back” to the moon reveals a total failure of logic and an embrace of empty symbolism. This manufactured triumph is a perfect symbol of an empire that can no longer distinguish reality from propaganda, nor achievement from theatrics.

This isn’t about space exploration; it’s about the degradation of meaning. A society that celebrates a symbolic loop as a monumental return has lost its ability to assess value and substance. It eagerly consumes the spectacle while ignoring the substance — or lack thereof. This willingness to applaud a non-event is a symptom of a deeper sickness: a population so cognitively damaged that it cannot perform the most basic reality checks. It is ready to be sold any story, no matter how hollow, as long as it’s wrapped in the flag and accompanied by a press release. The provided sources on this specific NASA mission are limited, but the pattern of celebrating engineered narratives over tangible reality is a hallmark of our cognitive decline.

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