Biologists Create a New Type of Human Cells

Professor Vincent Pasque and his colleagues at KU Leuven have used stem cells to create a new kind of human cell in the lab. The new cells closely mirror their natural counterparts in early human embryos. As a result, scientists are better able to understand what occurs just after an embryo implants in the womb. The was recently published in the journal Cell Stem Cell.

A human embryo implants in the womb around seven days after fertilization if everything goes correctly. Due to technological and ethical constraints, the embryo becomes unavailable for study at that point. That is why scientists have already created stem cell models for various kinds of embryonic and extraembryonic cells in order to investigate human development in a dish.

Vincent Pasque’s team at KU Leuven has developed the first model for a specific type of human embryo cells, extraembryonic mesoderm cells. Professor Pasque: “These cells generate the first blood in an embryo, help to attach the embryo to the future placenta, and play a role in forming the primitive umbilical cord. In humans, this type of cell appears at an earlier developmental stage than in mouse embryos, and there might be other important differences between species. That makes our model especially important: research in mice may not give us answers that also apply to humans.”

The model cells were created by the researchers using human stem cells, which can still grow into all cell types in an embryo. The new cells closely resemble their natural counterparts in human embryos and hence serve as an excellent model for that cell type.

Keep reading

US government plans to develop AI that can unmask anonymous writers

The Office of the Director of National Intelligence (ODNI) said that the Intelligence Advanced Projects Activity (IARPA) is working on a program to unmask anonymous writers by using AI to analyze their writing style which is seen as potentially being as unique as a fingerprint.

“Humans and machines produce vast amounts of text content every day. Text contains linguistic features that can reveal author identity,” IARPA said.

If successful, IARPA believes the Human Interpretable Attribution of Text Using Underlying Structure (HIATUS) program could identify a writer’s style from different samples and modify those patterns to further anonymize the writing.

“We have a strong chance of meeting our goals, delivering much-needed capabilities to the Intelligence Community, and substantially expanding our understanding of variation in human language using the latest advances in computational linguistics and deep learning,” said HIATUS program manager Dr. Timothy McKinnon.

IARPA said that it will also develop explainability standards for the program’s AIs.

Keep reading

Genetically Modified Mosquitoes Vaccinate a Human

A box full of genetically modified mosquitoes successfully vaccinated a human against malaria in a trial funded by the National Institutes of Health (NIH).

The study involved about 200 hungry mosquitos biting a human subject’s arm. Human participants placed their arms directly over a small box full of the bloodsuckers.

“We use the mosquitoes like they’re 1,000 small flying syringes,” said researcher Dr. Sean Murphy, as reported by NPR.

Three to five “vaccinations” took place over 30-day intervals.

The mosquitoes gave minor versions of malaria that didn’t make people sick, but gave them antibodies. Efficacy from the antibodies lasted a few months.

“Half of the individuals in each vaccine group did not develop detectable P. falciparum infection, and a subset of these individuals was subjected to a second CHMI 6 months later and remained partially protected. These results support further development of genetically attenuated sporozoites as potential malaria vaccines,” researchers concluded.

Carolina Reid was one of twenty-six participants in the study.

“My whole forearm swelled and blistered. My family was laughing, asking like, ‘why are you subjecting yourself to this?’”

Reid enjoyed her experience so much that she says she wants to participate in as many vaccine trials as she can. For this research, each participant received $4,100 as an incentive.

Keep reading

Israel explains remote-controlled checkpoint gun

The Israeli army has installed a remote-controlled gun turret in the Palestinian city of Hebron in the West Bank, saying it’s to be used for crowd dispersal.

The sci-fi-looking style is positioned at a checkpoint on Shuhada Street, a protest hotspot in the city, Haaretz reported at the weekend.

The system, which is currently being tested, can fire stun grenades, tear gas and sponge-tipped bullets, while being controlled by a remote operator.

“As part of the army’s improved preparations for confronting people disrupting order in the area, it is examining the possibility of using remotely controlled systems for the employment of approved measures of crowd dispersal,” a military spokesman told the Israeli paper.

Keep reading

THROUGH THE LOOKING-GLASS: ODD NEW METASURFACE MATERIAL IS A “DOORWAY” TO STRANGE QUANTUM PHENOMENON

A phenomenon that often accompanies technological innovations involves how they tend to become smaller with their improvement over time. From televisions and communication devices like telephones to computers and microchip components, many of the technologies we use every day occupy a fraction of the space in our homes and offices that their predecessors did just decades ago.

In keeping with this trend, it is no surprise that a new tech developed by scientists at Sandia National Laboratories, in cooperation with the Max Planck Institute for the Science of Light, may soon replace cumbersome technologies than once required an entire room to operate, thanks to an ultrathin invention that could change the future of computation, encryption, and a host of other technologies.

At the heart of the invention and its function is a peculiar phenomenon that has perplexed physicists for decades, known as quantum entanglement.

Entanglement involves particles (photons, in this case) that are linked in such a way that any changes that affect one of them will affect the other. Strangely, the distance between entangled particles does not affect the way such changes occur, a peculiarity first described by Albert Einstein, Boris Podolsky, and Nathan Rosen in 1935, which Einstein called “spooky action at a distance.”

Although physicists have difficulty reconciling this mainstay of the quantum mechanical world with our concepts of classical mechanics, scientists have nonetheless succeeded in tapping the strange phenomenon of entanglement in developing new information technologies, improving encryption technologies, and even correcting errors in the burgeoning field of quantum computing.

Now, the creation of an all-new material by the Sandia Labs and Max Planck Institute team could further improve efforts to harness quantum entanglement in the production of innovative new technologies.

Keep reading

Corporate Investors Pour Billions Into ‘Digital Snoops’ to Spy on Workers’ Every Move

For generations, workers have been punished by corporate bosses for watching the clock. But now, the corporate clock is watching workers! They count this as progress.

Called “digital productivity monitoring,” it’s an integrated computer system including a real-time clock, camera, keyboard tracker and algorithms to provide a second-by-second record of what each employee is doing.

Jeff Bezos, boss of Amazon, pioneered the use of this ticking electronic eye in his monstrous warehouses, forcing hapless, low-paid “pickers” to sprint down cavernous stacks of consumer stuff to fill online orders, pronto — beat the clock or be fired.

“Terrific policy!” exclaimed taskmasters at hospital chains, banks, tech giants, newspapers, colleges and other outfits employing millions of midlevel professionals.

So, they’ve been installing these unblinking digital snoops to watch their employees, even timing bathroom breaks and constantly eyeing each worker’s job performance.

New software with such Orwellian names as “WorkSmart” and “Time Doctor” has been plugged in to count workers’ keystrokes and — every 10 minutes — to snap pictures of workers’ faces and screens, recording all on individual scoreboards.

You are paid only for the minutes the computers “see” you in action. Bosses hail the electronic minders as “Fitbits” of productivity, spurring workers to keep noses to the grindstone and instilling workplace honesty.

Only … the whole scheme is dishonest. No employee’s worthiness can be measured in keystrokes and 10-minute snapshots!

What about thinking, conferring with colleagues, listening to customers, etc.? Nope — zero “productivity points” are awarded for that work.

For example, The New York Times reports that the multibillion-dollar United Health Group marks its drug-addiction therapists “idle” if they are conversing offline with patients, leaving their keyboards inactive.

Employees mostly call this digital management “demoralizing,” “toxic” and “just wrong.” But corporate investors are pouring billions into it. Which group do you trust to shape America’s workplace?

Keep reading

Deepfake audio has a tell – researchers use fluid dynamics to spot artificial imposter voices

Imagine the following scenario. A phone rings. An office worker answers it and hears his boss, in a panic, tell him that she forgot to transfer money to the new contractor before she left for the day and needs him to do it. She gives him the wire transfer information, and with the money transferred, the crisis has been averted.

The worker sits back in his chair, takes a deep breath, and watches as his boss walks in the door. The voice on the other end of the call was not his boss. In fact, it wasn’t even a human. The voice he heard was that of an audio deepfake, a machine-generated audio sample designed to sound exactly like his boss.

Attacks like this using recorded audio have already occurred, and conversational audio deepfakes might not be far off.

Deepfakes, both audio and video, have been possible only with the development of sophisticated machine learning technologies in recent years. Deepfakes have brought with them a new level of uncertainty around digital media. To detect deepfakes, many researchers have turned to analyzing visual artifacts – minute glitches and inconsistencies – found in video deepfakes.

Keep reading

New doorbell technology can deny access to Covid-positive people

An invention that is yet to be patented, is marketed by its author as “the world’s first Covid-19 doorbell” – a multi-biometric device called Pulse Secure Doorbell, the intellectual property (IP) of which has been offered for sale or licensing with a price tag in excess of a million dollars.

This doorbell is the brainchild of Ross Markbreiter, who appears to be behind Pulse Security Systems. The content-wise sparse website for the project states that what makes the device “unique” is that it is equipped not only with a camera but also an infrared (IR) “beam” (thermometer) that takes a person’s temperature, as well as a fingerprint scanner that takes the pulse and starts biometric scanning to confirm identity.

The camera is used for facial recognition, and what increasingly sounds like a full-fledged “biometric lab” rather than any “doorbell” you currently know of also incorporates a microphone for voice recognition.

If the checks are completed to the satisfaction of whatever the requirements of those who use the system are, green lights will be on, all the elements will turn on, and the door opens. If not, access is denied.

“There is a speaker and a 911 button. A person will contact you if needed,” the website states.

Keep reading

Why are hard drive companies investing in DNA data storage?

The research community is excited about the potential of DNA to function as long-term archival storage. That’s largely because it’s extremely dense, chemically stable for tens of thousands of years, and comes in a format we’re unlikely to forget how to read. While there has been some interesting progress, efforts have mostly stayed in the research community because of the high costs and extremely slow read and write speeds. These are problems that need to be solved before DNA-based storage can be practical.

So we were surprised to hear that storage giant Seagate had entered into a collaboration with a DNA-based storage company called Catalog. To find out how close the company’s technology is to being useful, we talked to Catalog’s CEO, Hyunjun Park. Park indicated that Catalog’s approach is counterintuitive on two levels: It doesn’t store data the way you’d expect, and it isn’t focusing on archival storage at all.

Keep reading