Tag: opioid epidemic

Marijuana And Opioids Are ‘Equally Efficacious’ In Reducing Pain, With Cannabis Offering Additional ‘Holistic’ Benefits, Study Shows

Medical marijuana and opioids are “equally efficacious” at mitigating pain intensity in patients with chronic pain, according to a new study in the Journal of Cannabis Research—but cannabis also provided more “holistic” relief, such as by improving sleep, focus and emotional wellbeing.

Researchers said their findings support the hypothesis that medical cannabis (MC) “alleviates pain through holistically altering the pain experience” rather than “only targeting pain intensity.”

“The results of the present study support the hypothesis that the effects of MC on pain experience are more holistic than those of opioids,” their report says. “MC may alleviate pain through affecting a broad range of pain-related experience experiential factors such as relaxation, improved sleep and mood, being able not to react to the pain, as well as a sense of control.”

The nine-person Finnish team, led by Åbo Akademi University psychology professor Jussi Jylkkä, looked at a sample of 201 chronic pain patients, 40 of whom used medical marijuana and 161 of whom used opioids to treat pain. There was some crossover, with about 45 percent of medical marijuana patients reporting also using opioids for their pain and about 4.3 percent of opioid users having used medical cannabis.

Subjects completed retrospective surveys on the “positive and negative phenomenological effects of the medicine,” and researchers then compared scores from the two groups.

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Medical Marijuana Legalization Led To Reduction In Frequent Use Of Nonmedical Prescription Opioids, Study Finds

Legalizing medical marijuana is associated with a “lower frequency” of nonprescribed pharmaceutical opioid use, according to a study published this month in the International Journal of Mental Health and Addiction.

While the decrease was rather small—between about 0.6 percent and 1.5 percent for regular to frequent opioid use—and was concentrated in people who met diagnostic criteria for cannabis use disorder, the researchers said it could signal “substitution effects with partial replacement of opioids by cannabis.”

The research team, from the schools of public health at Rutgers and Columbia universities as well as the University of Arizona’s School of Government and Public Policy, said the results highlight “the importance of identifying tradeoffs of cannabis legalization as an intervention to reduce opioid-related harms.”

The study used national survey data from 2004 to 2014 to examine nonmedical prescription opioid (NMPO) use—specifically, prescription opioids used without a prescription or in a manner other than prescribed.

Despite the decrease in regular and frequent opioid use, the study also found that medical cannabis legalization (MCL) was associated with a 2.1 percent increase in the occasional use of nonmedical prescription opioids, defined as between once and 12 times per year.

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Mind-altering ketamine becomes new pain treatment, despite little research or regulation

As U.S. doctors scale back their use of opioid painkillers, a new option for hard-to-treat pain is taking root: ketamine, the decades-old surgical drug that is now a trendy psychedelic therapy.

Prescriptions for ketamine have soared in recent years, driven by for-profit clinics and telehealth services offering the medication as a treatment for pain, depression, anxiety and other conditions. The generic drug can be purchased cheaply and prescribed by most physicians and some nurses, regardless of their training.

With limited research on its effectiveness against pain, some experts worry the U.S. may be repeating mistakes that gave rise to the opioid crisis: overprescribing a questionable drug that carries significant safety and abuse risks.

“There’s a paucity of options for pain and so there’s a tendency to just grab the next thing that can make a difference,” said Dr. Padma Gulur, a Duke University pain specialist who is studying ketamine’s use. “A medical journal will publish a few papers saying, ‘Oh, look, this is doing good things,’ and then there’s rampant off-label use, without necessarily the science behind it.”

When Gulur and her colleagues tracked 300 patients receiving ketamine at Duke, more than a third of them reported significant side effects that required professional attention, such as hallucinations, troubling thoughts and visual disturbances.

Ketamine also didn’t result in lower rates of opioid prescribing in the months following treatment, a common goal of therapy, according to Gulur. Her research is under review for medical journal publication.

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How Iron-Clad Is the Iron Law of Prohibition?

IN LATE MAY 2023, at the National Institute of Standards and Technology in Gaithersburg, Maryland, Edward Sisco opened a package of swabs taken from used syringes and empty bags. Sisco, a research chemist, ran the samples through a mass spectrometer, a device about the size of a washing machine, and got back a chemical profile.

Sisco receives these swabs from needle exchanges in Maryland and four other states, to track what drugs people are using. Those drugs range from illicitly manufactured fentanyl, an opioid that has largely replaced heroin; benzodiazepines, a class of drugs used to treat anxiety; and 20 different cutting agents and adulterants, such as caffeine, quinine, and mannitol. The surveillance system, which the federal agency piloted in October 2021, also frequently turn up drugs that are contaminating the illicit drug supply in the U.S. Among these are xylazine, a veterinary sedative that goes by the street name tranq, short for tranquilizer; clickbait headlines sometimes refer to xylazine as a “zombie drug” because it causes necrotizing wounds, skin ulcers and knocks people out. Last year, Sisco found another animal tranquilizer, medetomidine, in a small percentage of samples. Xylazine has never been approved for use in humans, and neither sedative is a typical opioid, which complicates the use of antidotes, such as naloxone, to reverse overdoses.

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Epstein Victim Who Testified Against Ghislaine Maxwell Has Died—and Her Family Wants Answers

Carolyn Andriano, a victim of sex-trafficker Jeffrey Epstein whose testimony was crucial to putting away his accomplice Ghislaine Maxwell, has died.

There was no obituary or funeral service after she died earlier this year, and police in West Palm Beach, Florida, opened an investigation into her death. After The Daily Beast reached out for comment, police spokesman Mike Jachles told us that the investigation was concluding and that Carolyn died of an accidental overdose.

The 36-year-old mother-of-five had planned to start a new chapter in North Carolina, at a new house with a fireplace and half-acre lot with a chicken coop. Carolyn and her husband, John Pitts, had purchased the property just weeks before she was found unresponsive in a West Palm Beach hotel room on May 23.

Before her death, “she was ecstatic,” Carolyn’s mother, Dorothy Groenert, told The Daily Beast. “She was all set up for a whole new lifestyle.”

Groenert says Carolyn’s death came as a shock because she was working on building a new life and texted her recently about being free of drugs and alcohol.

The way Groenert sees it, some things about her daughter’s overdose don’t make sense, and she wants cops to investigate further.

Jachles, however, said that Carolyn’s case would officially be closed this week. Officers on the scene took a statement from Pitts, who told them that Carolyn had been using drugs, and Carolyn’s brother, who rushed to the hotel after Pitts texted Groenert that Carolyn had died. Pitts tried to administer CPR and “was given directions over the phone with 911,” Jachles said.

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Fentanyl’s littlest victims: Dozens of babies, toddlers die in Missouri and Kansas

The boy’s tiny lifeless body lay on a bed last year inside a home along The Paseo. When Kansas City police officers found 2-year-old Cillian Miller in August 2022, he was wearing only a green T-shirt and was naked from the waist down. Most of his body was covered in a blanket except his feet, which were already discolored, court records show. Strewn throughout the home were new and used syringes, glass pipes and “multiple strips of foil with apparent burnt residue.” One pipe was left underneath a partially eaten McDonald’s cheeseburger on the dining room table. And somewhere inside that home, the child came across fentanyl. Tests would later show the little boy was yet another victim of the drug ravaging the nation and taking hundreds of lives in the Kansas City area. In KC, and across both Missouri and Kansas, dozens of little children have died from the illicit drug in the past three years, The Star has found in an ongoing investigation into the toll fentanyl has taken on our community. This report on our youngest victims launches an extensive project that will include community outreach and stories about the broader impact of fentanyl on the Kansas City area and the challenges of policing the problem. Unlike other drug crises, including crack, these children aren’t suffering from debilitating addictions because their parents were using; they are dying of actual fentanyl overdoses. The babies and toddlers — ages 4 and under — have come across the synthetic opioid and its residue in their homes, inside hotel rooms and even at a city park. Their deaths have largely gone unnoticed, ending up as statistics inside annual state reports on child deaths or in records kept by county medical examiners. Most of the attention on fentanyl has focused on teens or young adults and the awareness that “one pill can kill.”

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THE U.S. GOVERNMENT IS PREPARING FOR A FENTANYL WMD ATTACK

LAST YEAR, the White House publicly shot down a controversial proposal from Republican lawmakers to designate fentanyl as a weapon of mass destruction. 

Though President Joe Biden declined to issue the executive order granting the WMD designation, which would have come with extraordinary powers to combat the scourge, federal agencies — including the Department of Defense, the FBI, and the Department of Homeland Security — had already begun preparing for a fentanyl WMD attack as far back as 2018.

Government documents obtained by The Intercept reveal that national security agencies have for years been advancing the narrative that the drug could pose a WMD threat, going so far as conducting military exercises in preparation for an attack by a fentanyl weapon.

The push to declare fentanyl a WMD — and the security state approaching the drug that way even absent the declaration — has been a boon to federal agencies’ budgets. It’s not clear, however, that reimagining the highly toxic drug as a superlethal weapon has had any effect of combating the ongoing crisis of fentanyl overdoses. What it has done, though, is help kick off a panic.

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‘Breaking Bad’ grandma Joanne Segovia could be snitching on alleged fentanyl ring accomplices: sources

The “Breaking Bad” grandma accused of running an international drug ring out of her San Jose, Calif., home appears to be cooperating with federal authorities, The Post has learned.

Legal sources told The Post the “wheels could already be in motion” as Joanne Segovia’s hearings in her federal case continue to get postponed — which they say typically indicates a deal being worked out.

Meanwhile, the 64-year old grandma appears to be remaining positive even with a possible 20-year prison sentence hanging over her head.

“She even told one of the neighbors the case had been dropped,” a source close to Segovia told The Post.

Segovia, who is out on bail and doesn’t have to wear an ankle monitor, hasn’t appeared in court since her initial appearance in March.

At that appearance, she pleaded not guilty. Segovia has previously claimed the mastermind behind the drug operation was actually her housekeeper — a “family friend” who suffered from a substance abuse problem, according to a Homeland Security Investigations report.

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Despite Debunking, Rainbow Fentanyl Myths Continue

In 2022, fears erupted over “rainbow fentanyl,” brightly colored fentanyl pills that were said to be designed by drug traffickers to lure innocent children into taking opioids. Parents were warned to be on the watch for the pills—especially in their children’s Halloween candy stash.

A warning from the Drug Enforcement Agency (DEA) released last August warned that the increasing presence of brightly colored pills “appears to be a new method used by drug cartels to sell highly addictive and potentially deadly fentanyl made to look like candy to children and young people.”

“Rainbow fentanyl—fentanyl pills and powder that come in a variety of bright colors, shapes, and sizes—is a deliberate effort by drug traffickers to drive addiction amongst kids and young adults,” added DEA Administrator Anne Milgram.

However, it was startlingly easy to debunk panic over rainbow fentanyl. As it turns out, drug dealers have plenty of willing adult customers. So why would these they try to lure children, a customer base with no money of their own? And why would dealers give away valuable stock to do so?

“I’m skeptical that [dealers] would try to target children where there is not an existing market,” Sally Satel, an addiction psychiatrist and resident fellow at the American Enterprise Institute, told Reason‘s Lenore Skenazy in 2022. Considering the high risk of overdose in children, Satel added that “few would survive and come back for more.”

Just as there are adult reasons for vape companies to sell flavored vape pods, which were the subject of another panic, there are adult reasons for dealers to color their fentanyl—namely, to “brand [their] stuff.”

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The Truth About Ron DeSantis’ Fentanyl Horror Story

The second Republican debate of the 2024 presidential campaign cycle took place at the Ronald Reagan Presidential Library on Wednesday, and at various points throughout the night the topic turned to drug policy.

The candidates argued over the proliferation of fentanyl—the synthetic opioid significantly more potent than morphine or heroin that is often found mixed with other narcotics purchased on the black market. Specifically, the candidates squabbled over who would most aggressively weaponize the military and federal power in an attempt to prevent illicit fentanyl from reaching American shores.

Some of the candidates deployed anecdotes gleaned from the campaign trail of people whose loved ones died of fentanyl overdoses in order to justify increasingly oppressive drug policy. But Gov. Ron DeSantis’s example is much more complicated than he let on.

“In Florida, we had an infant, 18 months [old],” DeSantis said. “Parents rented an Airbnb, and apparently the people that had rented it before were using drugs. The infant was crawling, the toddler was crawling on the carpet and ingested fentanyl residue and died. Are we just going to sit here and let this happen, this carnage happen in our country? I am not going to do that.” As he has in the past, DeSantis used the story to illustrate the need for tougher drug and immigration policy, up to and including shooting people as they cross the border with Mexico.

DeSantis’s campaign did not respond to a clarifying question by press time, but he seemed to be referring to Enora Lavenir, the 19-month-old daughter of a French couple vacationing in Wellington, a small Florida town near West Palm Beach. The Lavenirs rented a four-bedroom house through Airbnb, where on August 7, 2021, Enora’s mother Lydie Lavenir found her unconscious and foaming at the mouth. Paramedics rushed the girl to the hospital, where she was pronounced dead.

Last year, the Lavenirs filed a wrongful death suit against Airbnb, the property’s owners, and the most recent previous renter. The lawsuit has since been amended to add additional defendants including HomeAway, the parent company of Vrbo, another home-rental service through which the prior tenant rented the house. According to the lawsuit, “the medical examiner detected a lethal level of Fentanyl in Enora’s blood and determined that her cause of death was acute Fentanyl toxicity. Toxicology readings indicated a quick death, ruling out the possibility that Enora came into contact with Fentanyl anywhere else but in the Airbnb rental.”

Contrary to DeSantis’s statement at the debate, the lawsuit does not claim that Enora was “crawling on the carpet and ingested fentanyl residue.” In fact, the suit does not speculate exactly how Enora came into contact with the drug; it merely alleges that Airbnb and Vrbo have “known for years that drug use is prevalent in [their] properties” and “that drugs, paraphernalia, and residue are frequently left behind in rentals, that there is a substantial risk of them being left behind, and that when they are left behind they pose a fatal risk to future guests, including children and infants.”

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