Researchers Successfully Reverse Alzheimer’s in Mice: Peer-Reviewed Study

Scientists have reversed Alzheimer’s disease in mice, potentially showing a pathway to treat the illness among humans, according to a Dec. 22 peer-reviewed study published in the Cell Reports Medicine journal.

Alzheimer’s is traditionally considered irreversible. In the study, researchers treated two groups of mice with P7C3-A20, a pharmacologic agent. One group carried human mutations related to amyloid processing, while the other carried a tau protein mutation. Both amyloid and tau pathologies are two major early events of Alzheimer’s.

Researchers say that as mice develop brain pathologies resembling Alzheimer’s, they are ideal subjects to test how P7C3-A20 affects Alzheimer’s in humans.

Among the amyloid mice, treatment with P7C3-A20 was found to have resulted in restoring the proper balance of Nicotinamide adenine dinucleotide (NAD+), which is a cellular energy molecule and a major driver of Alzheimer’s disease. As people age, NAD+ levels decline in their bodies, including the brain. Without proper NAD+ balance, the cells are unable to execute critical processes necessary for proper functioning.

The treatment was found to have reversed blood-brain barrier deterioration, DNA damage, oxidative stress, and neuroinflammation, researchers wrote. The blood-brain barrier maintains nutrient and hormone levels in the brain while protecting the organ from toxins and pathogens.

The treatment enhanced synaptic plasticity and hippocampal neurogenesis, a process in which new functional neurons are generated.

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Is There Already a Cure for Alzheimer’s?

Therapies administered to treat Alzheimer’s disease could be doing more harm than good, while modern medicine ignores known effective treatments. This is according to a recent post by “A Midwestern Doctor” on The Forgotten Side of Medicine Substack.

Alzheimer’s is a runaway epidemic in many developed countries, and is increasingly prevalent in Latin America, Africa, and Asia. It is a progressive, neurodegenerative disease that accounts for a majority of dementia cases worldwide, and is one of the top-ranked causes of death in the United States. It involves the buildup of amyloid (protein) plaques in the brain, which causes memory, reasoning, and behavior problems.

Treating the Symptom

Modern therapies focus on removing those plaques, but according to the Substack Reversing Alzheimer’s: The Forgotten Causes and Cures Big Pharma Buried, amyloids build up because of a “mechanism the brain uses to protect itself from stressors that endanger brain tissue.” So attempting to treat Alzheimer’s by eliminating them is “doomed to fail.” In other words, mainstream treatment doesn’t work because it’s treating a symptom, not the source. However, “the money behind this juggernaut has caused research into the real causes of Alzheimer’s to be suppressed.”

The blog cites three peer-reviewed studies revealing new information that deserves attention:

  1. Reversal of Cognitive Decline: 100 Patients,” published in the Journal of Alzheimer’s Disease & Parkinsonism in 2018;
  2. Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project,” published in 2022 in the Journal of Alzheimer’s Disease; and
  3. The 2024 case series “Sustained Cognitive Improvement in Alzheimer’s Disease Patients Following a Precision Medicine Protocol,” published in the journal Biomedicines.

Bredesen’s Studies & Treatments

A researcher who took part in each of these studies is Dale E. Bredesen, who teaches at UCLA’s medical school in Los Angeles, California. His eponymous protocol involves applying individually targeted therapies to different cases of Alzheimer’s based on their cause.

For Bredesen, plaques are merely a symptom. He identifies six triggers that, over time, play a key role in disease development. They are inflammation, insulin resistance (chronically elevated blood sugar), nutrient and hormonal deficiencies, toxins, blood flow restrictions, and severe or chronic head trauma.

Bredesen’s recommended treatments vary based on these causes, but A Midwestern Doctor mentions a few. “China recently developed a surgery to increase the lymphatic drainage from the brain,” he writes, citing studies that show such drainage necessary “to eliminate amyloid from the brain.” Doctors have also witnessed impressive results with dimethyl sulfoxide (DMSO), a compound that is commonly used topically for pain and inflammation relief.

Doctors in more than 125 countries prescribe it for a plethora of other conditions, but the U.S. Food & Drug Administration limits its use. DMSO.org attributes that reticence to the death of a woman in Ireland in 1965. She had taken DMSO with several other drugs and suffered a severe allergic reaction. Though the causative agent was never determined, popular opinion attributed the death to DMSO, and the FDA shut down clinical trials. Since then, no other deaths attributable to DMSO have occurred.

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Microdosing Cannabis Pauses Alzheimer’s Decline in Unprecedented Trial

As the world’s population ages, the number of people living with dementias such as Alzheimer’s disease increases.

Given the lack of curative treatments and the limited effectiveness of available medications, interest in new therapeutic approaches is growing. Among them are cannabinoids from the cannabis plant.

A small new Brazilian study published in the international Journal of Alzheimer’s Disease investigated the effects of microdoses of cannabis extract on patients with mild Alzheimer’s disease. The results found positive effects, without the associated “high” of cannabis.

The logic of microdoses

The study, led by Professor Francisney Nascimento and colleagues at the Federal University of Latin American Integration (UNILA), recruited 24 elderly patients (60-80 years) diagnosed with mild Alzheimer’s.

It evaluated the effects of daily use of an oil prepared from cannabis extract containing THC and CBD in similar proportions and extremely low concentrations (0.3 mg of each cannabinoid). These sub-psychoactive doses do not cause the “high” associated with recreational use of the plant.

The extract used was donated by ABRACE, Brazil’s biggest patient association, and had no contribution from cannabis companies or other funding sources.

“Microdosing” is a term usually associated with recreational use of psychedelics. Given the size of the dose, it would be easy to question whether it could have any effect at all.

Doses below 1 mg of the cannabinoid compounds are not frequently reported in the literature of clinical practice. However, the researchers’ decision to use microdosing did not come out of nowhere.

In 2017, the group led by Andreas Zimmer and Andras Bilkei-Gorzo had already demonstrated that very low doses of THC restored cognition in elderly mice, reversing gene expression patterns and brain synapse density in the hippocampus to levels similar to those of young animals.

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Biden Goes Viral for All the Wrong Reasons at Eagles Game

Joe Biden had another embarrassing public appearance Sunday when he showed up to the Philadelphia Eagles-Las Vegas Raiders game at Lincoln Financial Field, bundled against the cold and looking about as lost as you’d expect.

Biden arrived on the sidelines before the 1 p.m. kickoff, standing in the snow with his wife, former First Lady Dr. Jill Biden, as they greeted Eagles owner Jeffrey Lurie. “Go Birds, man, all the way,” Biden said in a clip posted to NBC10’s John Clark’s X account “Gotta win the Super Bowl again.”

From there, it all pretty much went downhill. But, hey, at least he knew he was at a football game…. maybe.

FOX’s NFL account on X posted video of Biden watching the game from the sidelines, and social media quickly erupted in mockery as clips of him staring blankly spread across the platform.

Social media users quickly flooded comment sections with posts targeting Biden’s age and cognitive fitness.

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“Get Up and Fight Back!” – Joe Biden Shouts Out of Nowhere, Botches “America” During LGBTQ+ Victory Institute Speech

Joe Biden emerged from hiding on Friday to deliver remarks at a forum hosted by the LGBTQ+ Victory Institute.

Biden received the Chris Abele Impact Award for building the most LGBTQ+ inclusive administration in US history.

Biden was awarded for having a black lesbian press secretary, a gay Transportation Secretary, a nonbinary Department of Energy official who is into “pup kink,” and a transgender Assistant Secretary for Health.

They weren’t qualified to serve in those positions, but all that matters is that they were gay, nonbinary, or transgender.

“The LGBTQ+ Victory Institute—the only national organization dedicated to elevating out LGBTQ leaders at all levels of government—is proud to announce today that President Joe Biden will receive the Chris Abele Impact Award to honor his historic role in championing LGBTQ+ rights and for his leadership in achieving the most LGBTQ+ inclusive administration in U.S. history,” the organization said.

“President Biden will be the third recipient of the award in the Institute’s history,” the organization said.

“President Biden has shown unwavering commitment to ensuring LGBTQ+ people can participate fully and openly in our democracy,” said Evan Low, LGBTQ+ Victory Institute President & CEO.

“From appointing a record number of LGBTQ+ leaders to reversing harmful policies and expanding civil rights protections, his administration set a new and necessary standard for what inclusive governance looks like. And now, we’re seeing LGBTQ+ elected officials lead the way on everyday issues that are important to most Americans like groceries, housing, and lowering the costs of healthcare. This award honors not only his achievements, but also the real impact these changes have had on LGBTQ+ Americans across the country,” Low said.

Joe Biden shuffled over to the microphone and delivered an uninspiring speech.

At one point, Joe Biden shouted at the attendees and told them to “fight back” against the Trump Administration.

“Get up! Get up and fight back! Get up! Continue to fight! What’s the fight all about?! It’s about protecting the Constitution!” Biden shouted.

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Trump Suggests Michelle Obama Was Caught Using Joe Biden’s Autopen

President Donald Trump blasted open another online firehose Monday night, tossing out a fresh theory that Michelle Obama used Joe Biden’s notorious autopen.

Trump’s Truth Social account turned into a late-night rally, with the commander-in-chief unleashing more than 160 posts between 7 p.m. and midnight. Most of it came from MAGA influencers like YouTuber Benny Johnson and commentator Scott Jennings, who filled the feed with red-meat content for Trump’s base.

But the headline-grabber was a repost of Alex Jones. Trump boosted a video from the InfoWars host along with the claim that “Michelle Obama may have used Biden’s autopen in the final days of his disastrous administration to pardon key individuals.”

Trump has long accused Biden of leaning on a mechanical signing device to push through executive orders and pardons as his presidency sputtered to an end. Before leaving office, Biden granted clemency to several of Trump’s fiercest critics, including retired Gen. Mark Milley and Dr. Anthony Fauci.

However, so far, there does not appear to be much evidence that the former first lady had anything to do with Biden’s last-minute pardon spree.

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Trump Terminates All Biden-Era Executive Orders, Documents Signed By Autopen

President Donald Trump announced on Friday that he was moving to reverse all executive orders and documents from his predecessor, former President Joe Biden, that were signed with autopen technology.

“Any document signed by Sleepy Joe Biden with the Autopen, which was approximately 92% of them, is hereby terminated, and of no further force or effect,” the president announced in a Truth Social post.

“The Autopen is not allowed to be used if approval is not specifically given by the President of the United States. The Radical Left Lunatics circling Biden around the beautiful Resolute Desk in the Oval Office took the Presidency away from him. I am hereby cancelling all Executive Orders, and anything else that was not directly signed by Crooked Joe Biden, because the people who operated the Autopen did so illegally,” the post continued.

“Joe Biden was not involved in the Autopen process and, if he says he was, he will be brought up on charges of perjury. Thank you for your attention to this matter!”

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Biden Aides Admit to Bringing in Hollywood’s Spielberg and Katzenberg to Help Cover Up Biden Health Issues

The US House Oversight Committee releases its footage from interviews with Biden Aides. 

Biden was so bad that Aides brought in Steven Spielberg and Jeffrey Katzenberg from Hollywood to help limit the damage. 

We all know Biden was out to lunch.  We reported on it repeatedly.  Biden was lost.  This happened over and over.  It was embarrassing.  It was elderly abuse.

Now we know that Katzenberg and Spielberg were brought in to manage the Biden production and apparently prevent him from appearing so lost, confused, and senile.

The House Oversight Committee released its report and clips from interviews yesterday. Below are some clips from interviews with Biden Aides.

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Calls for Anthony Fauci be prosecuted amid Trump’s autopen declaration… while Biden also faces charge threat

Right-wingers are demanding that Anthony Fauci be brought up on charges after President Donald Trump said he revoked all of President Joe Biden‘s autopen-signed executive orders and pardons.

Fauci, who led the National Institute of Allergy and Infectious Diseases for nearly 40 years, received an autopen-signed pardon right before Trump retook the White House on January 20.

Because Trump has long argued that the autopen signatures should not be treated as authentic – while also factoring in Biden’s cognitive decline – Republicans are voicing their belief that Fauci could be prosecuted for alleged wrongdoing during the COVID-19 pandemic.

Marjorie Taylor Greene led the charge, writing on X Friday that if ‘autopen pardons are repealed then prosecute Fauci for crimes against humanity’. The Daily Mail approached Greene’s office for further comment.

Nicolas Hulscher, an epidemiologist who works with the McCullough Foundation, said it was ‘time to PROSECUTE Anthony Fauci.’

The McCullough Foundation is known in part for spreading the unsubstantiated claim that vaccines are leading cause of autism.

Another account on X pointed out that Fauci has been referred for criminal charges by Senator Rand Paul, who claims the doctor lied to Congress about gain of function research in Wuhan, China.

Some US intelligence agencies, including the FBI, CIA and Energy Department, all believe with varying degrees of confidence that the SARS-CoV-2 virus could have leaked from the Wuhan Institute of Virology.

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Will Trump’s autopen executive order de-bench 237 leftist federal judges (including Ketanji Brown Jackson)?

On Thursday, I wrote that leftist judges on the bench are creating a form of tyranny, for they have arrogated to themselves the constitutional power of the Executive branch of government. There is no more balance. According to the Democrat appointees on the bench, none of Trump’s actions are solely within the discretion of the democratically elected chief executive. Instead, all are subject to judicial review and approval.

The day after I wrote that essay, Trump issued a statement via Truth Social voiding every document that was signed with an Autopen during Joe Biden’s presidency and threatening Biden along the way:

Any document signed by Sleepy Joe Biden with the Autopen, which was approximately 92% of them, is hereby terminated, and of no further force or effect. The Autopen is not allowed to be used if approval is not specifically given by the President of the United

States. The Radical Left Lunatics circling Biden around the beautiful Resolute Desk in the Oval Office took the Presidency away from him. I am hereby cancelling all Executive Orders, and anything else that was not directly signed by Crooked Joe Biden, because the people who operated the Autopen did so illegally. Joe Biden was not involved in the Autopen process and, if he says he was, he will be brought up on charges of perjury. Thank you for your attention to this matter!

Some have pointed out that this order is merely performative, since one president can always undo another’s executive orders.

As an aside, that line of argument is untrue. As we’ve seen, district courts have repeatedly held that Donald Trump cannot reverse the executive orders of previous presidents. That’s the special unwritten Donald Trump rule. Their rulings are always dressed up in fancy language and erroneous legal arguments, but the net result has been that what other presidents do, Trump cannot undo. (ChatGPT struggles with this concept, but you can get the idea of what’s going on here.)

More important than that argument’s inaccuracy is a practical reality: Voiding all of Biden’s Autopen signatures doesn’t just end policy Executive Orders. In theory, it also ends every judicial nomination Biden made, from Ketanji Brown Jackson on down.

This matters a great deal, not just because of Jackson, but because Biden was able to nominate the largest number of federal judges in a single term since the Carter administration, 235 in all. Most of them have proven to be distinguished only by their “diversity,” not their intelligence, legal acumen, or fidelity to the Constitution and the rule of law.

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