Tag: senility

Alzheimer’s Drugs Have No ‘Meaningful Effect’ on Cognitive Decline: Review

A class of Alzheimer’s drugs that have only been available for several years did not appear to have any “clinically meaningful effects,” according to a new review of clinical trial data.

Monoclonal antibodies that target plaque called amyloid beta in the brain showed little impact across 17 trials, Francesco Nonino, a neurologist and epidemiologist who directs the Unit of Epidemiology and Statistics at the IRCCS Institute of Neurological Sciences of Bologna, Italy, and co-authors wrote in the review.

“The effect of amyloid‐beta‐targeting monoclonal antibodies on cognitive function and dementia severity at 18 months in people with mild cognitive impairment or mild dementia due to Alzheimer’s disease is trivial, while on functional ability, it is small at best,” they said.

“Successful removal of amyloid from the brain does not seem to be associated with clinically meaningful effects in people with mild cognitive impairment or mild dementia due to Alzheimer’s disease. Future research on disease‐modifying treatments for Alzheimer’s disease should focus on other mechanisms of action,” they added later.

The review covered 17 studies involving 20,342 participants. The drugs were typically compared with placebos in the trials, which were all funded by pharmaceutical companies.

The monoclonal antibodies in question were first approved by the U.S. Food and Drug Administration in 2021. They include Lecanemab, which is available in the United States and other countries and is produced by Eisai and Biogen, and Eli Lilly’s Donanemab.

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LAUGHABLE: Rep. Jamie Raskin Who Repeatedly Defended Joe Biden’s Mind of Mush is Now Demanding a Cognitive Assessment of President Trump

Rep. Jamie Raskin and other House Democrats are demanding that the White House perform a cognitive assessment of President Trump and publish the results.

Republicans, members of the Trump administration, and the general public should point and laugh at these people. Ridicule them harshly until they wander away in defeat.

These are the same people who not only defended Joe Biden for four years, but smeared anyone who dared to question Biden’s obvious issues of mental acuity.

The Hill reported:

Raskin asks White House physician for ‘comprehensive cognitive assessment’ of Trump

Rep. Jamie Raskin (D-Md.) on Friday pressed the White House physician for a full evaluation of President Trump’s cognitive abilities.

In a letter to Sean Barbabella, a Navy captain serving as Trump’s official doctor, Raskin argued that Trump’s words and actions in recent months — particularly those surrounding the Iran war — have raised enough questions about the president’s mental acuity to merit a “comprehensive cognitive assessment.” Raskin wants the results shared publicly.

“Experts have repeatedly warned that the President has been exhibiting signs consistent with dementia and cognitive decline. And, in recent days, the country has watched President Trump’s public statements and outbursts turn increasingly incoherent, volatile, profane, deranged, and threatening,” wrote Raskin, the senior Democrat on the House Judiciary Committee.

“His apparently deteriorating condition has caused tremendous alarm across the nation (and political spectrum) about the President’s cognitive function and continuing mental fitness for the office of President, and prompted concerns about the President’s wellbeing.”

These people have no shame whatsoever.

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While Pushing New Book, Jill Biden Claims Joe Biden Made the ‘Unprecedented Decision’ Not to Seek Reelection in 2024

Former First Lady Jill Biden is releasing a new book about her time in the White House because of course she is. What else are she and Joe going to do for money other than write books and go on book tours?

In a video she released on social media, she claims that it was Joe who made the unprecedented decision to not seek reelection in 2024. That seems like a bit of historical revisionism.

Actor George Clooney wrote an op-ed for the NY Times demanding that Joe Drop out of the race and many people suspect that Obama played a role in the writing of the piece. Joe only dropped out of the race when Democrat donors made it clear that they would not donate another dime as long as Biden was the nominee. Chuck Schumer had private meetings with Biden and so did Nancy Pelosi.

But it was Joe Biden’s decision to drop out? OK.

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Grab the Popcorn: Trump Executive Privilege Decision Means All That Info on Biden Is Coming Out

President Donald Trump just made a big decision that will likely expose a lot of information that was not released about Joe Biden during his occupation of the Oval Office. 

Trump has rejected Biden’s claim of executive privilege to not turn over documents requested in various Senate probes, determining it is “not in the best interests of the United States.” 

White House counsel David Warrington wrote Monday in a letter addressed to the National Archives and Records Administration (NARA) and obtained by Fox News Digital that Trump “does not uphold the former President’s assertion of privilege” over records sought in four congressional probes. The letter directs NARA to provide the materials to Congress.

The dispute centers on documents related to investigations into Biden’s health, alleged politically motivated probes into Trump and his allies, and the Biden family’s financial dealings, which Republicans argue go to the heart of Congress’s constitutional authority to conduct oversight.

That means that the White House is telling NARA to turn over anything about the “cover-up” of “Biden’s health and cognitive decline.” Imagine all the potential documents that could involve — we could see all the machinations and who specifically did what regarding any concealing of his cognitive decline. 

“The abuse of the autopen that took place during the Biden Presidency, and the extraordinary efforts to shield President Biden’s diminished faculties from the public, must be subject to a full accounting to ensure nothing similar ever happens again,” Warrington wrote, quoting a prior letter.

Warrington had previously weighed in when Trump denied the executive privilege regarding the autopen issue. 

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Study: Lifetime Cannabis Use Not Associated With Cognitive Decline or Dementia Risk in Older Adults

Cannabis use by older adults is not associated with either accelerated cognitive decline or greater risk of dementia, according to findings published in the journal BMJ Mental Health.

Investigators affiliated with Yale University and the University of Oxford in the United Kingdom assessed cognitive performance in lifetime cannabis consumers and non-users across various domains — including memory, intelligence, and problem solving. Data was drawn from two large nationally representative cohorts (the UK Biobank and the US Million Veteran Program), consisting of several hundred thousand participants.

Researchers reported that those with a history of cannabis use “demonstrated significantly better cognitive performance,” a finding that is consistent with prior studies. Cannabis use “was not associated with increased risk of dementia” and researchers found “no supporting evidence of a causal link with [longitudinal] cognitive decline in later life.”

The study’s authors concluded: “This study represents one of the largest observational investigations to date examining the relationship between cannabis use, cognitive function and dementia risk in older adults. … Our findings are broadly consistent with prior population-based longitudinal studies that have not observed accelerated age-related cognitive decline associated with cannabis use. … Clinicians can consider that occasional or prior cannabis use may not be a major contributor to cognitive aging in this population.”

Commenting on the findings, NORML’s Deputy Director Paul Armentano said: “These results contradict one of the more prominent and longstanding stereotypes about cannabis and cannabis consumers. It is unfortunate that these stereotypes often go unchallenged in the media and elsewhere. It is even more unfortunate that studies refuting these long-held stereotypes seldom receive the type of mainstream attention they deserve.”

Several other recent studies have reported similar results. For example, an Israeli study of over 67,000 older adults reported that participants with a history of cannabis use “performed better across all cognitive domains: attention, executive function, processing speed, visual and working memory. … Additionally, past use was associated with a slower decline in executive function.”

A Danish study similarly concluded that cannabis consumers experienced “significantly less cognitive decline” over their lifetimes than did non-users.

Most recently, a study published in January in the Journal of Studies on Alcohol and Drugs concluded: “Greater lifetime [cannabis] use was also associated with better performance on cognitive tasks assessing learning, memory, processing speed, and task switching, aligning with growing evidence of potential neuroprotective effects of cannabis in aging populations. … This study adds to a growing body of evidence that cannabis use may be associated with greater brain volume and cognitive performance in aging adults, especially in regions rich in cannabinoid receptors.”

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Biden Autopen Investigation is Ongoing and NOT Closed

Fox News reported on Thursday that the Justice Department’s investigation into Biden’s autopen is ongoing – NOT closed – as previously reported by The New York Times, CBS News, and NBC News.

Fox News cautioned that Joe Biden is not the target of the investigation.

On Wednesday, The New York Times and other outlets, citing sources, reported that prosecutors in Jeanine Pirro’s office dropped the criminal case into whether Joe Biden’s aides unlawfully used the autopen to issue pardons.

According to Fox News, the Biden autopen investigation is ongoing.

Per Fox News: It is also clear that the target of any potential prosecution would NOT be former president Biden himself, “It’s hard to imagine how [Biden] could be criminally liable for pardon power,” said the senior DOJ official, describing that power as basically limitless.

The Oversight Project broke the story about the Biden autopen scandal wide open after they discovered thousands of acts of clemency and executive actions were signed with an autopen rather than a wet signature.

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The Biden Autopen Probe Ends the Way So Many Others Do

Tell me if you’ve heard this before.

Former President Joe Biden avoids charges after federal prosecutors closed the probe into his use of an autopen to sign pardons and other documents. Prosecutors in Washington reviewed the case, examined whether Biden authorized the signatures himself, and decided there were no crimes committed.

Like March that comes in like a lion, the investigation launched with big promises but ended quietly, adding to the increasingly rotten pattern in which scandals evaporate without consequences.

Last June, President Donald Trump ordered an investigation into whether the Biden administration used an autopen to sign key presidential documents, such as pardons, months after Mr. Trump had claimed his predecessor’s pardons were illegitimate.

Mr. Trump told Attorney General Pam Bondi and the White House counsel in a memo to probe what he claimed was a “conspiracy” to “abuse the power of Presidential signatures through the use of an autopen to conceal Biden’s cognitive decline.”

The order cited a number of executive actions by Biden, including pardons and judicial appointments, and argued: “There are serious doubts as to the decision-making process and even the degree of Biden’s awareness of these actions being taken in his name.” 

Despite concerns that lawmakers and conservative media had about Biden’s lack-of-mental state in his final months, suggesting staff overstepped their roles … crickets.

What are we left with? Another grand declaration of justice that crumbles into nothing, leaving everyone to wonder if some secret shield protects the powerful or if the whole thing was just hot air from the beginning.

Jeanine Pirro leads as U.S. Attorney for the District of Columbia, and her office reviewed Biden’s pardons and actions. Prosectors couldn’t find any law that bans the use of an autopen if the president approves it. Without proof, the case gets dropped.

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A Barely Coherent Joe Biden Tells South Carolina Crowd That HE Closed the Border – NOT Trump 

Joe Biden slammed President Trump on Friday evening during a political event in South Carolina.

“We’re honored to welcome President Joe Biden to Columbia on Friday, February 27, for a reception commemorating his pivotal 2020 South Carolina primary victory and thank him for a lifetime of public service,” The South Carolina Democrat Party said.

Joe Biden was a mess when he deplaned in South Carolina.

He wandered over to a woman in a wheelchair, took her phone and froze up before an aide intervened.

Later Friday evening Joe Biden delivered remarks at an event hosted by the South Carolina Democrat Party at the Columbia Museum of Art.

Biden slammed President Trump and blamed Covid for the border crisis during his speech.

Joe Biden absurdly claimed that HE closed the border – NOT President Trump.

“The day I left office, border crossings in the United States were lower than the day that I entered that office and inherited from Trump. He’s – I won’t say it,” Biden said.

“On the day I left office, I handed Trump the strongest economy in the world! In the world! And that’s not hyperbole. That’s a fact!” Biden said even though near record inflation was crushing Americans in January 2025.

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James Comer Slams Pam Bondi DOJ After Viral Chart Shows ZERO Arrests — DOJ Still Sitting on Biden Autopen Pardons Trump Says Are Null and Void

The American people are demanding accountability, but the Department of Justice under Pam Bondi is still dragging its feet.

House Oversight Committee Chairman James Comer is publicly blasting the Department of Justice under Attorney General Pam Bondi after investigative reporter Catherine Herridge highlighted a viral chart circulating on X that exposes a jaw-dropping lack of accountability — zero arrests tied to some of the biggest political scandals of the last decade.

The chart lays out a long list of scandals that dominated headlines for years, from the Russia collusion narrative and Benghazi to election fraud and the Biden autopen scandal, and they all share the same outcome: zero arrests.

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Researchers Successfully Reverse Alzheimer’s in Mice: Peer-Reviewed Study

Scientists have reversed Alzheimer’s disease in mice, potentially showing a pathway to treat the illness among humans, according to a Dec. 22 peer-reviewed study published in the Cell Reports Medicine journal.

Alzheimer’s is traditionally considered irreversible. In the study, researchers treated two groups of mice with P7C3-A20, a pharmacologic agent. One group carried human mutations related to amyloid processing, while the other carried a tau protein mutation. Both amyloid and tau pathologies are two major early events of Alzheimer’s.

Researchers say that as mice develop brain pathologies resembling Alzheimer’s, they are ideal subjects to test how P7C3-A20 affects Alzheimer’s in humans.

Among the amyloid mice, treatment with P7C3-A20 was found to have resulted in restoring the proper balance of Nicotinamide adenine dinucleotide (NAD+), which is a cellular energy molecule and a major driver of Alzheimer’s disease. As people age, NAD+ levels decline in their bodies, including the brain. Without proper NAD+ balance, the cells are unable to execute critical processes necessary for proper functioning.

The treatment was found to have reversed blood-brain barrier deterioration, DNA damage, oxidative stress, and neuroinflammation, researchers wrote. The blood-brain barrier maintains nutrient and hormone levels in the brain while protecting the organ from toxins and pathogens.

The treatment enhanced synaptic plasticity and hippocampal neurogenesis, a process in which new functional neurons are generated.

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