Tag: gmo

Greenpeace Crusade Will Blind and Kill Children

Greenpeace and other anti-biotech activist groups have logged a win in a crusade that could ultimately blind and kill thousands of children annually. How? By persuading the Court of Appeals of the Philippines to issue a scientifically ignorant and morally hideous decision to ban the planting of vitamin A–enriched golden rice. The objective result will be more children blinded and killed by vitamin A deficiency.

The World Health Organization estimates that 250,000–500,000 children who are vitamin A–deficient become blind every year, and half of them die within 12 months of losing their sight. In addition, children with immune systems weakened by vitamin A deficiency have an increased risk of illness and death from infectious diseases.

The court also banned the planting of an eggplant variety that has been biotech-enhanced to resist insect pests. The same variety approved by Bangladeshi regulators has reduced pesticide usage and improved farmers’ yields by more than 50 percent.

In their press release, Greenpeace activists crowed, “The Court of Appeals has essentially put a moratorium on these genetically modified crops.”

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COMPANY CLAIMS ITS ‘DIRECTED EVOLUTION’ MICROBIOME-ENHANCED PLANTS LITERALLY EAT POLLUTION FOR BREAKFAST

Bioengineering R&D company Neoplants says its ‘directed evolution’ houseplants can clean the air inside your home 30 times more efficiently than an ordinary houseplant. This is due to genetically engineered bacteria that convert some of the most common and dangerous indoor air pollutants, known as Volatile Organic Compounds (VOC), into biodegradable components like sugar that the plant ultimately consumes as food.

This means harmful pollutants Benzene, Toluene, and Xylene, which can reach as much as five times (or even up to 100 times) the concentration indoors as they do outdoors, are not only filtered out of the air, but their breakdown products are used to feed the plant itself, thereby “turning a harmful and commonly found chemical in your home into a healthy source of fuel for the plant.”

“It harnesses the power of nature to purify indoor air from 3 of the most carcinogenic pollutants we find in every home, up to 30 times better than any regular houseplant,” explained Lio Mora, Neoplants CEO, and co-founder, in an email to The Debrief.

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US company hoping to bring back the dodo and the mammoth – but here’s why it won’t be like Jurassic Park

The idea of scientists bringing pre-historic creatures back to life with some clever DNA trickery might sound familiar to fans of the 1993 Hollywood blockbuster Jurassic Park.

But for Colossal Biosciences – a company that hopes to reintroduce extinct species such as the dodo and the mammoth – it is more than just a film script.

It’s a reality – and one that could be just years away.

“We’ve got all the technology we need,” says Ben Lamm, chief executive of the firm, based in Dallas, Texas.

“It is just a focus of time and funding. But we are 100% confident [we can bring back] the Tasmanian tiger, the dodo, and the mammoth.”

The science behind the project is simple: Work out the genes that make an extinct animal what it is, and then replicate those genes using the DNA of a close existing relative.

“It’s almost reverse Jurassic Park,” says Mr Lamm, speaking to Sky News.

“In the film, they were filling in the holes in the dinosaur DNA with frog DNA.

“We are leveraging artificial intelligence and other tools to identify the core genes that make a mammoth a mammoth and then engineering them into elephant genomes.”

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Scientists Put Tardigrade Proteins Into Human Cells. Here’s What Happened.

Freeze ’em, heat ’em, blast them into empty space; with survival skills unlike any other organism on the planet, those hardy critters known as tardigrades will only come back for more.

While it’s clear their ability to withstand stress is in part due to their ability to turn their insides into gel, the mechanisms behind this act of metabolic preservation haven’t yet been made clear.

A new study led by researchers from the University of Wyoming found that expressing key tardigrade proteins in human cells slowed metabolism, providing critical insights into how these virtually indestructible invertebrates can survive under the most extreme conditions.

The team focused on a particular protein called CAHS D, already known to protect against extreme drying (desiccation). Through a variety of methods, the researchers showed how CAHS D transformed into a gel-like state when under stress, keeping molecules protected and protecting against drying.

“This study provides insight into how tardigrades, and potentially other desiccation-tolerant organisms, survive drying by making use of biomolecular condensation,” write the researchers in their published paper.

“Beyond stress tolerance, our findings provide an avenue for pursuing technologies centered around the induction of biostasis in cells and even whole organisms to slow aging and enhance storage and stability.”

Tardigrades have already shown they can survive hot and cold temperatures and high levels of radiation that would be fatal to human beings, and long periods without any water – normally so essential to life. They can even survive in space.

Previous research has revealed an impressive number of tricks that tardigrades use to stay alive, built up over hundreds of millions of years. Essentially, they’re very good at slowing the processes of life right down with the help of CAHS D, and that could be useful in human cells too.

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Scientists Close To Controlling All Genetic Material On Earth

Scientists at the University of Pennsylvania’s Perelman School of Medicine have developed a new method to create human artificial chromosomes (HACs) that could revolutionize gene therapy and other biotechnology applications. The study, published in Science, describes an approach that efficiently forms single-copy HACs, bypassing a common hurdle that has hindered progress in this field for decades.

Artificial chromosomes are lab-made structures designed to mimic the function of natural chromosomes, the packaged bundles of DNA found in the cells of humans and other organisms. These synthetic constructs have the potential to serve as vehicles for delivering therapeutic genes or as tools for studying chromosome biology. However, previous attempts to create HACs have been plagued by a major issue: the DNA segments used to build them often link together in unpredictable ways, forming long, tangled chains with rearranged sequences.

The Penn Medicine team, led by Dr. Ben Black, sought to overcome this challenge by completely overhauling the approach to HAC design and delivery. “The HAC we built is very attractive for eventual deployment in biotechnology applications, for instance, where large-scale genetic engineering of cells is desired,” Dr. Black explains in a media release. “A bonus is that they exist alongside natural chromosomes without having to alter the natural chromosomes in the cell.”

To test their idea, the scientists turned to a tried-and-true workhorse of molecular biology: yeast. They used a technique called transformation-associated recombination (TAR) cloning to assemble a whopping 750 kilobase DNA construct in yeast cells. For context, that’s about 25 times larger than the constructs used in previous HAC studies. The construct contained DNA from both human and bacterial sources, as well as sequences to help seed the formation of the centromere.

The next challenge was to deliver this hefty payload into human cells. The team accomplished this by fusing the engineered yeast cells with a human cell line, a process that had been optimized in previous studies. Remarkably, this fusion approach proved to be much more efficient than the traditional method of directly transferring naked DNA into cells.

The results were stunning. Not only did the engineered HACs form successfully, but they did so with much higher efficiency compared to standard methods. Furthermore, these designer chromosomes were able to replicate and segregate properly during cell division, a key requirement for their long-term stability and functionality.

“Instead of trying to inhibit multimerization, for example, we just bypassed the problem by increasing the size of the input DNA construct so that it naturally tended to remain in predictable single-copy form,” explained Dr. Black.

But the researchers didn’t stop there. They also devised a clever way to visualize the HACs in their native, uncompacted state. By gently lysing the cells and using a special centrifugation technique, they were able to isolate the HACs away from the rest of the cellular DNA. This allowed them to confirm that the HACs maintained their single-copy status and circular topology, without any unwanted rearrangements or additions.

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Chinese Scientists Implant First Pig Liver Into Brain-Dead Human

Who says nothing interesting ever happens in the world anymore? This week, in a “first of its kind” operation, a brain-dead human subject was implanted with the world’s first gene-edited pig liver transplant, according to SCMP. 

In what could be a pioneering move, Chinese scientists have transplanted a gene-edited pig liver into a human, aiming to potentially mark a solution to organ shortages, the report says.

The liver was modified to reduce rejection risks and was implanted into a brain-dead recipient, showing no rejection signs four days post-operation, as per the Air Force Medical University. SCMP writes that this procedure could significantly aid those with end-stage liver disease, possibly revolutionizing liver transplants. 

Gene editing advancements in China also promise to enhance efficiency and accessibility in plant modification, reflecting broader strides in medical innovation, the report continues.

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A little bit of Pfizer in your cheese? Fake rennet bypassed additive approval process

Pfizer’s bioengineered rennet turns your milk into cheese
You may be surprised to learn that the cheese you are eating, if it’s not USDA organic, most likely contains synthetic rennet bioengineered by Pfizer. Often referred to as microbial rennet, the source of the rennet is not required to be listed on food labels, so most Americans have no idea that the food they are eating contains non-natural ingredients.

Pfizer’s bioengineered rennet turns your milk into cheese

You may be surprised to learn that the cheese you are eating, if it’s not USDA organic, most likely contains synthetic rennet bioengineered by Pfizer. Often referred to as microbial rennet, the source of the rennet is not required to be listed on food labels, so most Americans have no idea that the food they are eating contains non-natural ingredients.

Global Research‘s Dr. Ashley Armstrong, who believes that natural rennet is preferable to synthetic rennet, explained that cheese making involves just four ingredients — milk, salt, starter culture, and (traditionally) animal rennet. Rennet is used to curdle the cheese and separate the curds from the whey. Today, rennet comes from more than one source, the others being “vegetable rennet, microbial rennet, and a genetically modified version called FPC (fermentation-produced chymosin). Chymosin is one of the two enzymes found in natural animal rennet, the other being pepsin:

Animal rennet is usually 90% chymosin enzyme and 10% pepsin enzyme. The small amount of pepsin will break down the casein protein in milk in a slightly different way compared to just chymosin alone, producing a final product with an enhanced taste.

Supreme Court rules new life forms can be patented

The permissibility for manufacturers to make synthetic rennet resulted from a 1980 Supreme Court ruling that new life forms can be patented. As VRG’s (Vegetarian Resource Group) research director Jeanne Yacoubou, MS, explained, this became pivotal to the development of synthetic rennet FPC (fermentation produced chymosin) when animal rennet started rising in price as a result of the animal rights movement:

When calf rennet became scarce and unreliably available in the 1960s and 70s as the veal industry was declining due to the animal rights movement but demand for cheese increased, calf rennet became very expensive. Companies looked for a “rennet substitute.” Recombinant DNA technologies involving microbes were becoming popular and companies turned to it in the 1980s. [Emphases added.]

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Montana Man Pleads Guilty to Creating Massive Franken-Sheep With Cloned Animal Parts

An 80-year-old man in Montana pleaded guilty Tuesday to two felony wildlife crimes involving his plan to let paying customers hunt sheep on private ranches. But these weren’t just any old sheep. They were “massive hybrid sheep” created by illegally importing animal parts from central Asia, cloning the sheep, and then breeding an enormous hybrid species.

Arthur “Jack” Schubarth, 80, owns and operates the 215-acre “alternative livestock” ranch in Vaughn, Montana where he started this operation in 2013, according to a press release from the U.S. Department of Justice. Alternative livestock includes hybrids of mountain sheep, mountain goats, and other large mammals which are often used for trophy hunting by wealthy people.

An unnamed accomplice of Schubart kicked off the decade-long scheme by illegally bringing biological tissue from a Marco Polo sheep, the largest sheep in the world, from Kyrgyzstan into the U.S. in 2013, according to prosecutors.

How big are these sheep? An average male can weigh over 300 pounds with horns over 5 feet wide, giving them the largest sheep horns on the planet. The sheep are endangered and protected by both international treaties and U.S. law. Montana also forbids the import of these foreign sheep or their parts in an effort to protect local American sheep from disease.

Once Schubart had smuggled his sheep parts into the U.S., he sent them to an unnamed lab which created 165 cloned embryos, according to the DOJ.

“Schubarth then implanted the embryos in ewes on his ranch, resulting in a single, pure genetic male Marco Polo argali that he named ‘Montana Mountain King’ or MMK,” federal authorities wrote in a press release.

By the time Schubart had his Montana Mountain King he used the cloned sheep’s semen to artificially impregnate female sheep, creating hybrid animals. The goal, as the DOJ explains it, was to create these massive new sheep that could then be used for sports hunting on large ranches. Schubart also forged veterinarian inspection certificates to transport the new hybrid sheep under false pretenses, and sometimes even sold semen from his Montana Mountain King to other breeders in the U.S.

Schubart sent 15 artificially inseminated sheep to Minnesota in 2018 and sold 37 straws of Montana Mountain King’s semen to someone in Texas, according to an indictment filed last month. Schubart also offered to sell an offspring of the Montana Mountain King, dubbed the Montana Black Magic, to someone in Texas for $10,000.

Discussions between Schubart and an unnamed person apparently included what to call this new breed of sheep they were creating. The other person said another co-conspirator had suggested the name “Black Argali,” though noting “we can’t,” presumably because it would give away the fact that these sheep were descended from the argali species.

Schubart pleaded guilty to violating the Lacey Act, and conspiracy to violate the Lacey Act, which makes it a crime to acquire, transport or sell wildlife in contravention of federal law.

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GLOWING PLANTS THAT TURN ENERGY INTO LIGHT ARE ABOUT TO BE COMMERCIALLY AVAILABLE FOR THE FIRST TIME

Tapping into the magic of bioluminescence, Light Bio is preparing to ship its first orders for glowing plants this spring. The company provides flora that converts energy into light, making their offerings the first commercially available plants that glow in the dark.

After scaling up production to meet excessive demands, Light Bio says it will finally begin shipping orders for their glowing “Firefly Petunia,” which was so named because its glowing leaves resemble fireflies, next month.

Some plant and animal species in nature convert chemical energy into visible light, causing them to glow. While the majority of these seemingly magical lifeforms are aquatic, some take the form of glowing plants. Among the most studied are bioluminescent mushrooms that glow in the dark.

Some laboratories have been able to combine the genes responsible for these glowing fungi into more aesthetically pleasing plants, including flowers. However, genetic engineering is complicated, and the most common process involves incorporating five different genes into the target plant to generate light. The science is also highly regulated, meaning glowing plants have thus far existed as a laboratory curiosity and nothing more.

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90% of U.S. Cheese Contains GMO Made by Pfizer

Who doesn’t love cheese?! And for good reason — it is not only delicious but also incredibly nutritious. And despite what the mainstream tells us, humans have been making and consuming this superfood for over 7,000 years. In fact, cheese serves an important role in human history.

Historians document that milk, dairy and fermented dairy products, like cheese, served as a nutrient-dense calorie source that was storable, allowing some of the first explorers to safely travel and expand communities, creating more demographic shifts and diverse farming communities.

“Dairy provided food security, as it is a nutrient-rich superfood.

“Consumption of milk and dairy products would have had many advantages for early farming populations. Milk, yogurt, and cheese are good sources of calories, protein, and fat. They provide a reliable food between harvests or during droughts, epidemics, or famines.

“Milk is a relatively pathogen-free source of fluids that could be critical during times of water scarcity. Cheese provides a means of storing these nutrients to be used when milk production is low, and can be easily transported.

“Furthermore, fermentation of milk into yogurt or cheese lowers lactose content and allows lactose intolerant individuals to reap the benefits, while maintain, or in some cases enhancing, other essential nutrients such as fat and calcium.”

But cheese was traditionally made with just these four ingredients:

  1. Milk.
  2. Salt.
  3. Starter culture, what’s used to make the desired cheese strain (for ex. Muenster versus Swiss).
  4. Animal rennet is used as a clotting agent to curdle the milk into cheese, separating the liquid parts of milk from the solids — a very vital part of the cheese-making process!

You add culture to milk and let it ferment. Then, you add rennet, which separates the milk into curds and whey. Then you press the curds and age them. And voila — cheese!

Rennet is a complex set of enzymes that are naturally produced in the stomachs of ruminant animals, like cows.

The main enzyme present is chymosin, which is a protease enzyme, meaning it breaks down protein. Rennet from animals also contains other enzymes like pepsin and lipase.

So these enzymes in rennet target casein, the main protein in milk. They cause the casein molecules to divide and re-coagulate into even larger clumps, forming cheese curds.

So, rennet serves as a vital part of cheesemaking since it helps curdle the milk into cheese, separating the liquid part from the solid part.

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