Tag: dna

Billions Of Copies Of Residual DNA In A Single Dose Of COVID-19 mRNA Vaccine: Preprint

A new preprint study up for peer review finds billions of residual DNA fragments in the COVID-19 mRNA vaccine vials.

The lead author of the study, molecular virologist David Speicher, who has a doctorate in virology, told The Epoch Times that their study is “the largest study” on residual DNA in COVID-19 vaccines to date.

“In our study, we measured DNA copies of spike, ori (origin of replication), and SV40 enhancer genes,” he told The Epoch Times. “The loads of SV40 enhancer-promoter, ori, and virus spike in Pfizer are up to 186 billion copies per dose.”

The spike he refers to is the DNA sequence of the SARS-CoV-2 spike protein, which can be transcribed to spike mRNA to be used in the COVID-19 mRNA vaccines to be translated to spike protein. The other two DNAs—SV40 enhancer genes and ori—help facilitate the replication of spike DNA.

However, the final mRNA vaccines should only include RNA and not residual DNA instructions for spike production.

The researchers sequenced the gene material in 27 mRNA vaccine vials from 12 different lots. Nineteen vials were from Moderna, and eight were from Pfizer.

“Further work is needed to investigate if anything in these vaccines is actually integrating into the human genome and what effect that may have,” the lead author wrote.

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Robert F. Kennedy Jr. Vindicated – China’s Top Spy Agency Warns of “Gene Weapons’ Able to Target Specific Ethnicity or Race

In July, Robert Kennedy, Jr. took heat from the leftwing media and The New York Post after he alleged that both the U.S. and China had done research into ethnically-targeted bioweapons.

Kennedy added, “History shows that Jews, Africans, and the indigenous have the most to fear from such technologies,” he said, adding, “We must rein in all bioweapons research, whether these weapons are ethnically targeted or not. We saw what COVID did to the world when it was leaked from a laboratory.“

Kennedy made these comments after NY Post reporter Jon Levine wrote a hit piece on Kennedy after sitting next to him at “party filled with farting and beer drinking” and accused him of anti-Semitism for suggesting the COVID Pandemic hit some ethnic groups harder than others and that European Ashkenazi Jews and Asians fared better with the virus.

During the party Robert Kennedy, Jr. spoke about how scientists are now developing viruses as bioweapons. The US is sponsoring these laboratories financially. And scientists are currently working on ethnically targeted microbes. This was all true

On Tuesday, the top Spy Agency in China confirmed that “some countries” have armed themselves with deadly bioweapons targeting human genes. This was the first time a Chinese state body has mentioned such a threat publicly.

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Cure for HIV could be months away as first three patients are injected with new CRISPR therapy that seeks and destroys lingering pieces of virus

After four decades and over 700,000 Americans dead, gene editing experts believe they are on the cusp of curing HIV. 

Three patients in California have just been injected with genetic material along with an enzyme called CAS9 that early studies suggest can splice sections of the virus’ DNA that become lodged in human cells, eliminating it entirely.

Using the gene-editing technology CRISPR, a cure for the AIDS-causing virus could be closer on the horizon than ever thought before. 

The current trial aims to prove the treatment is safe, but data on how well it work is expected next year.

HIV was a near-certain death sentence until the mid-90s, when antiviral medications turned it into a chronic disease that people can live with. 

In total 1.2 million Americans have HIV and, even with access to medicine, have a risk of seeing their dormant infection resurface and potentially progress to AIDS.

Treatment options have evolved considerably since HIV was first identified in the early 80s. The course of treatment went from patients having to take several pills a day that might not even work well to start, to taking just a single daily pill that combines all of the best known therapies into one. 

These are known as antiretroviral therapies, or daily medications that tamp down the amount of virus in the blood to undetectable levels. These medications are effective, they are not a cure. 

A cure for HIV has eluded scientists for decades because of the unique way in which the virus hijacks the body’s own cells.   

HIV hides in immune cells in the body, where they can shield themselves from being destroyed by other immune cells. This makes hunting and killing HIV in the body difficult, because there is a risk of damaging healthy cells as well. 

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Researchers Alarmed to Find DNA Contamination in Pfizer Vaccine

Phillip Buckhaults, a cancer genomics expert, and professor at the University of South Carolina has testified before a South Carolina Senate Medical Affairs Ad-Hoc Committee saying that Pfizer’s mRNA vaccine is contaminated with billions of tiny DNA fragments.

Buckhaults, who has a PhD in biochemistry and molecular biology, said “there is a very real hazard” that these fragments of foreign DNA can insert themselves into a person’s own genome and become a “permanent fixture of the cell.”

He said it’s a plausible mechanism for what might be “causing some of the rare but serious side effects like death from cardiac arrest” in people following mRNA vaccination.

Buckhaults is not an alarmist and has been reluctant to go public with his findings for fear of frightening people.

He himself was vaccinated three times with Pfizer’s covid vaccine and recommended it to family and friends. He described the mRNA platform technology as “revolutionary” and said the vaccine has saved many lives.

“I’m a real fan of this platform,” Buckhaults told the Senate. “I think it has the potential to treat cancers, I really believe that this platform is revolutionary. In your lifetime, there will be mRNA vaccines against antigens in your unique cancer. But they’ve got to get this problem fixed.”

Buckhaults is most concerned about the “very real theoretical risk of future cancer in some people, depending on where this foreign piece of DNA lands in the genome, it can interrupt a tumour suppressor gene or activate an oncogene.”

“I’m kind of alarmed about this DNA being in the vaccine… DNA is a long-lived information storage device. It’s what you were born with, you’re going to die with and pass on to your kids. … So alterations to the DNA…well, they stick around,” he said.

Buckhaults believes the vaccines were deployed in good faith, but given the panic and urgency of the crisis, “there were a lot of shortcuts taken.” He puts it down to incompetence not malice, quoting Hanlon’s razor…

“…. which is never attribute malice to that which can be better explained by incompetence. There could be malice underneath, but I’m trying to see just incompetence to be gracious,” he told the Senate.

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Human-Pig Hybrid Created in the Lab

In a remarkable—if likely controversial—feat, scientists announced that they have created the first successful human-animal hybrids. The project proves that human cells can be introduced into a non-human organism, survive, and even grow inside a host animal, in this case, pigs.

This biomedical advance has long been a dream and a quandary for scientists hoping to address a critical shortage of donor organs.

What if, rather than relying on a generous donor, you could grow a custom organ inside an animal instead?

That’s now one step closer to reality, an international team of researchers led by the Salk Institute reports in the journal Cell. The team created what’s known scientifically as a chimera: an organism that contains cells from two different species.

In the past, human-animal chimeras have been beyond reach. Such experiments are currently ineligible for public funding in the United States (so far, the Salk team has relied on private donors for the chimera project). Public opinion, too, has hampered the creation of organisms that are part human, part animal.

But for lead study author Jun Wu of the Salk Institute, we need only look to mythical chimeras—like the human-bird hybrids we know as angels—for a different perspective.

“In ancient civilisations, chimeras were associated with God,” he says, and our ancestors thought “the chimeric form can guard humans.” In a sense, that’s what the team hopes human-animal hybrids will one day do.

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Scientists Create New Material Five Times Lighter and Four Times Stronger Than Steel

Materials that are both strong and lightweight can improve everything from cars to airplanes to medical equipment. Now, researchers have created an extraordinarily strong material with very low density–using two unlikely building blocks: DNA and glass.

“For the given density, our material is the strongest known,” according to Seok-Woo Lee of the University of Connecticut, who partnered with colleagues from Columbia University and Brookhaven National Lab.

“I am a big fan of Iron Man movies,” mused nanomaterials scientist Oleg Gang. “I have always wondered how to create a better armor for Iron Man. It must be very light for him to fly faster. It must be very strong to protect him from enemies’ attacks.

“Our new material is five times lighter but four times stronger than steel.”

Some metals, such as titanium, are stronger and lighter than iron. Certain alloys are even stronger—allowing for lightweight body armor, better medical devices, and safer, faster cars and airplanes. Metallurgical techniques have reached a limit in recent years, until nano materials unleashed creative opportunities.

The colleagues reported in Cell Reports Physical Science that by building a structure out of DNA and then coating it with glass, they have created a very strong material with very low density. Glass might seem a surprising choice, as it shatters easily. However, glass usually shatters because of a flaw – such as a crack, scratch, or missing atoms – in its structure. A flawless cubic centimeter of glass can withstand 10 tons of pressure, more than three times the pressure that imploded the Oceangate Titan submersible near the Titanic this summer.

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FBI HOOVERING UP DNA AT A PACE THAT RIVALS CHINA, HOLDS 21 MILLION SAMPLES AND COUNTING

THE FBI HAS amassed 21.7 million DNA profiles — equivalent to about 7 percent of the U.S. population — according to Bureau data reviewed by The Intercept.

The FBI aims to nearly double its current $56.7 million budget for dealing with its DNA catalog with an additional $53.1 million, according to its budget request for fiscal year 2024. “The requested resources will allow the FBI to process the rapidly increasing number of DNA samples collected by the U.S. Department of Homeland Security,” the appeal for an increase says.

In an April 2023 statement submitted to Congress to explain the budget request, FBI Director Christopher Wray cited several factors that had “significantly expanded the DNA processing requirements of the FBI.” He said the FBI collected around 90,000 samples a month — “over 10 times the historical sample volume” — and expected that number to swell to about 120,000 a month, totaling about 1.5 million new DNA samples a year. (The FBI declined to comment.)

The staggering increases are raising questions among civil liberties advocates.

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POLICE ARE GETTING DNA DATA FROM PEOPLE WHO THINK THEY OPTED OUT

CECE MOORE, AN actress and director-turned-genetic genealogist, stood behind a lectern at New Jersey’s Ramapo College in late July. Propelled onto the national stage by the popular PBS show “Finding Your Roots,” Moore was delivering the keynote address for the inaugural conference of forensic genetic genealogists at Ramapo, one of only two institutions of higher education in the U.S. that offer instruction in the field. It was a new era, Moore told the audience, a turning point for solving crime, and they were in on the ground floor. “We’ve created this tool that can accomplish so much,” she said.

Genealogists like Moore hunt for relatives and build family trees just as traditional genealogists do, but with a twist: They work with law enforcement agencies and use commercial DNA databases to search for people who can help them identify unknown human remains or perpetrators who left DNA at a crime scene.

The field exploded in 2018 after the arrest of Joseph James DeAngelo as the notorious Golden State Killer, responsible for more than a dozen murders across California. DNA evidence collected from a 1980 double murder was analyzed and uploaded to a commercial database; a hit to a distant relative helped a genetic genealogist build an elaborate family tree that ultimately coalesced on DeAngelo. Since then, hundreds of cold cases have been solved using the technique. Moore, among the field’s biggest evangelists, boasts of having personally helped close more than 200 cases.

The practice is not without controversy. It involves combing through the genetic information of hundreds of thousands of innocent people in search of a perpetrator. And its practitioners operate without meaningful guardrails, save for “interim” guidance published by the Department of Justice in 2019.

The last five years have been like the “Wild West,” Moore acknowledged, but she was proud to be among the founding members of the Investigative Genetic Genealogy Accreditation Board, which is developing professional standards for practitioners. “With this incredibly powerful tool comes immense responsibility,” she solemnly told the audience. The practice relies on public trust to convince people not only to upload their private genetic information to commercial databases, but also to allow police to rifle through that information. If you’re doing something you wouldn’t want blasted on the front page of the New York Times, Moore said, you should probably rethink what you’re doing. “If we lose public trust, we will lose this tool.”

Despite those words of caution, Moore is one of several high-profile genetic genealogists who exploited a loophole in a commercial database called GEDmatch, allowing them to search the DNA of individuals who explicitly opted out of sharing their genetic information with police.

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Luzio, who lived in São Paulo 10,000 years ago, was Amerindian like Indigenous people now, DNA reveals

An article published on July 31 in Nature Ecology & Evolution reveals that Luzio, the oldest human skeleton found in São Paulo state (Brazil), was a descendant of the ancestral population that settled the Americas at least 16,000 years ago and gave rise to all present-day Indigenous peoples, such as the Tupi.

Based on the largest set of Brazilian archaeological genomic data, the study reported in the article also offers an explanation for the disappearance of the oldest coastal communities, the residents of which built the icons of Brazilian archaeology known as “sambaquis,” huge mounds of shells and fishbones used as dwellings, cemeteries and territorial boundaries. Archaeologists often refer to these monuments as shell mounds or kitchen middens.

“After the Andean civilizations, the Atlantic coast sambaqui builders were the human phenomenon with the highest demographic density in pre-colonial South America. They were the ‘kings of the coast’ for thousands and thousands of years. They vanished suddenly about 2,000 years ago,” said André Menezes Strauss, an archaeologist at the University of São Paulo’s Museum of Archaeology and Ethnology (MAE-USP) and principal investigator for the study.

The authors analyzed the genomes of 34 samples from four different areas of Brazil’s coast. The fossils were at least 10,000 years old. They came from sambaquis and other parts of eight sites (Cabeçuda, Capelinha, Cubatão, Limão, Jabuticabeira II, Palmeiras Xingu, Pedra do Alexandre and Vau Una).

This material included Luzio, São Paulo’s oldest skeleton, found in the Capelinha river midden in the Ribeira de Iguape valley by a group led by Levy Figuti, a professor at MAE-USP. The morphology of its skull is similar to that of Luzia, the oldest human fossil found to date in South America, dating from about 13,000 years ago. The researchers thought it might have belonged to a biologically different population from present-day Amerindians, who settled in what is now Brazil some 14,000 years ago, but it turns out they were mistaken.

“Genetic analysis showed Luzio to be an Amerindian, like the Tupi, Quechua or Cherokee. That doesn’t mean they’re all the same, but from a global perspective, they all derive from a single migratory wave that arrived in the Americas not more than 16,000 years ago. If there was another population here 30,000 years ago, it didn’t leave descendants among these groups,” Strauss said.

Luzio’s DNA also answered another question. River middens are different from coastal ones, so the find cannot be considered a direct ancestor of the huge classical sambaquis that appeared later. This discovery suggests there were two distinct migrations—into the hinterland and along the coast.

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Scientists Inserted Neanderthal And Denisovan Genes Into Mice – Here’s What Happened

A gene that was carried by both Neanderthals and Denisovans causes mice to develop larger heads, twisted ribs, and shortened spines, according to the results of a yet-to-be-published study. Researchers used CRISPR gene editing technology to insert the ancient genetic code into rodents in order to understand how it might have contributed to the body shape of our extinct relatives.

The gene in question is known as GLI3 and plays a vital role in embryonic development in modern humans. Mutations within this gene are associated with physical malformations such as polydactyly – which refers to the growth of extra fingers or toes – and the deformation of the skull.

Neanderthals and Denisovans both carried a slightly altered version of the GLI3 gene, in which an amino acid at one end of the coding region is substituted. However, neither of these ancient species had an abnormal number of digits or life-threatening cranial defects.

As the study authors point out, though, these extinct hominid species displayed several morphological characteristics that differed from those of modern humans, “including elongated and low crania, larger brow ridges, and broader rib cages.”

To determine how the ancient form of the GLI3 gene might have affected the development of our extinct cousins, the researchers first engineered mice to carry a faulty version of the gene. This caused the rodents to develop severe skull and brain deformities as well as polydactyly, illustrating how a functioning version of the gene is essential for healthy embryonic growth.

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