Psychedelics Have ‘Promising Medical Applications,’ Congressional Watchdog Agency Says, But Research Challenges Remain

A federal agency has published a short report on the medical use of psychedelics, finding that their ability to “change a person’s perceptions and sense of self” can make for “promising medical applications.”

The paper, from the Government Accountability Office (GAO), says there’s a need for further research, but it also notes that because psychedelics such as LSD, MDMA and psilocybin remain Schedule I controlled substances, securing permission to carry out that research can be a challenge.

“To conduct research on these drugs, scientists need to follow several steps,” the report from GAO, which is often referred to as Congress’s “watchdog,” states in a section about ongoing challenges. “These include obtaining permission from the U.S. Drug Enforcement Administration, finding clinical grade drugs to test, and identifying appropriate spaces in which to test and store these drugs.”

“Difficulties associated with conducting large, blind trials of psychedelics have limited researchers’ ability to determine the safety and effectiveness of these drugs,” GAO continues, “which is required for them to gain approval from the Food and Drug Administration (FDA). FDA approval is generally required before prescription drugs can be marketed for sale in the U.S.”

Despite the obstacles, the paper acknowledges that hundreds of clinical trials have investigated psychedelics as a potential treatment for post-traumatic stress disorder (PTSD) and depression.

“Between 2015 and early 2025, over 340 trials on psychedelics began or were completed,” it says. “For example, one study found that psilocybin reduced depression symptoms more than escitalopram, an SSRI.”

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Coating Dentures With CBD Can Help Prevent Oral Infections, Government-Funded Study Shows

A newly published journal article says the cannabis component CBD could be an effective way to avoid oral infections when incorporated into the primary material used in dentures.

Published last month in the journal Molecules, the government-funded research says bonding CBD to dentures demonstrates “potential for antibiotic-free denture coatings, reducing dental biofilms and plaque formation, and improving oral health outcomes.”

To study the properties of CBD in dentures, researchers incorporated the cannabinoid into a type of plastic known as poly(methyl methacrylate) (PMMA), which the paper explains is “the primary material for dentures due to its favorable physical and aesthetic qualities.” Researchers then tested antimicrobial activity against three types of bacteria: Staphylococcus aureusEscherichia coli and Streptococcus agalactiae.

Results showed that the CBD denture coatings had “significant bactericidal effects” against so-called Gram-positive bacteria. In terms of Gram-negative bacteria—which are typically more resistant to antibiotics—the CBD coating was ineffective against free-floating, so-called “planktonic” Gram-negative bacteria but effectively eliminated communities of bacteria known as biofilms.

“Biofilm studies revealed a 99% reduction in biofilm growth for both Gram-positive and Gram-negative bacteria on CBD-infused PMMA compared to standard PMMA,” the report says. “The CBD disrupted bacterial cell ways, causing lysis,” or the breakdown of the cell itself.

“In summary,” authors wrote, “biofilm studies showed PMMA/CBD coatings were effective in eradicating all the pathogens on their surface.”

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Kentucky Senate Panel Votes To Ban Sale Of Hemp-Derived Beverages On A Temporary Basis

Kentucky lawmakers advanced a “shell” bill Wednesday evening to ban the sale of hemp-derived beverages in the state until summer of 2026, a move supporters say will allow time to understand how intoxicating versions of the beverages are impacting consumers.

But those involved in the hemp industry decried the proposed moratorium on the sale of hemp-derived beverages as hampering, or even crippling, small businesses trying to market, distribute or sell the canned beverages that are gaining popularity across the country and popping up in places including convenience stores.

Senate Bill 202 sponsor Sen. Julie Raque Adams (R-Louisville) said the goal of her bill is to better understand and regulate intoxicating hemp-derived beverages similar to how the state regulates other intoxicating beverages such as beer or liquor.

She spoke to lawmakers alongside Rep. Matthew Koch (R- Paris) with a line of cans on a desk featuring various flavors and amounts of infused non-intoxicating cannabidiol, known as CBD, and other cannabinoids, which can include intoxicating tetrahydrocannabinol, or THC.

“We are simply placing a moratorium on their sale until such time as we can establish robust regulations that protect Kentucky consumers and, most importantly, Kentucky children,” Adams said. “We have a real, I think, consumer protection issue going on right now. We need to make sure that Kentucky gets this right.”

Legislative concerns about regulating hemp-derived beverages sprang into public view on the 22nd day of this year’s 30-day session. The deadline for filing bills in the Senate was February 18.

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Ohio GOP Lawmaker Files Bill To Revise Voter-Approved Marijuana Law With Less Sweeping Changes Than Senate-Passed Measure

A Republican Ohio lawmaker has introduced a rival bill to Senate-passed legislation that seeks to amend the state’s voter-approved marijuana legalization law. And the proposed changes in the House measure are less sweeping—for example, maintaining the current allowable amount of cannabis plans that can be grown at home by adults.

Rep. Brian Stewart (R), chair of the House Finance Committee, is sponsoring the new 120-page cannabis bill.

Unlike the Senate proposal from Sen. Steve Huffman (R) that moved through the full chamber late last month, Stewart’s legislation would not alter a provision of the current law allowing adults 21 and older to grow up to 12 plants for personal use by cutting that amount in half.

However, it would reduce the maximum THC limit for cannabis extracts from 90 percent to 70 percent, as News 5 Cleveland first reported.

The Senate bill would lower the maximum household plant limit for home cultivation from 12 to six, but it similarly calls for the same reduced THC cap. Both bills would also make it so only 350 dispensaries could be licensed in the state.

“While there will obviously continue to be good faith debate and disagreement over the pros and cons of legalization, a majority of our constituents have made it clear to us that they support legal adult-use marijuana that is taxed at a reasonable rate, that is regulated by the state to ensure products are as safe as possible and that can, if desired, be grown at home,” Stewart said during a press briefing on Thursday.

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Committee In Tennessee Signs Off On Proposal To Tighten Restrictions On Hemp Industry

Despite warnings that the hemp industry would be decimated, the House Judiciary Committee passed a measure Wednesday that would put stricter regulations in place.

Sponsored by House Majority Leader William Lamberth (R) of Portland, House Bill 1376 would place the industry under the Alcoholic Beverage Commission instead of the Department of Agriculture and remove products from convenience and grocery stores. Only vape and liquor stores would be allowed to sell some hemp products.

The House bill is set to be heard next in the Commerce Committee, where agreements with the industry could be reached.

“It does ban [derivatives] THCA and THCP. The reason for that is we have not legalized marijuana in this state,” Lamberth said.

Hemp is distinguished from marijuana in that it contains a compound called delta-9 THC. Cannabis with a concentration of less than 0.3 percent delta-9 THC is defined as legal hemp in Tennessee—and federally. Cannabis with concentrations greater than 0.3 percent is classified as marijuana and is illegal to grow, sell or possess in Tennessee.

Hemp flowers also contain THCA, a nonintoxicating acid that would be banned in Tennessee under this bill. When heated or smoked, the THCA in the plant converts into delta-9 THC—an illegal substance in Tennessee in greater than trace amounts.

Clint Palmer, a representative of the hemp industry, told lawmakers the bill is similar to one passed in 2023 that led to a lawsuit against the Department of Agriculture that remains in litigation.

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Governor Youngkin’s expected cannabis veto: A $3.5 billion gift to Mexican cartels and Chinese gangs

As Governor Glenn Youngkin once again faces a bipartisan bill that would establish a regulated cannabis distribution platform in Virginia, it is widely anticipated that he will act against the public’s interest just as he did in March 2024. In the twelve months since his last veto, the only certainty is that Mexican cartels and Chinese gangs have benefited from $3.5 billion in untaxed, unregulated cannabis sales while the proliferation of hemp-based THC products has skyrocketed. We anticipate that Youngkin will once again roll out his prohibitionist arguments but will fail to point to any tangible decrease in illegal cannabis sales the over the last 12-month— further proving that gifting Mexican cartels and Chinese drug dealers $3.5 billion and allowing the proliferation of illegal stores from Arlington to the Tennessee state line has only benefited organized crime at the expense of Virginians.

Youngkin’s argument hinges on a fundamental contradiction. He acknowledges that Virginia’s current system is “pervasive and dangerous,” yet refuses to implement the one policy proven to reduce illegal markets — regulation. Instead, he clings to outdated scare tactics, misrepresenting data from other states while ignoring the realities of his own.

Prohibitionists once used the same flawed logic to keep whiskey illegal, relying on bootleggers to supply demand while enriching organized crime. The parallels to cannabis today are undeniable. By refusing to regulate cannabis, Youngkin is ensuring that the only suppliers are Mexican cartels and Chinese gangs, just as Prohibition once empowered the Mafia. This policy failure is not just historical irony — it is a $3.5 billion mistake.

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Idaho Lawmakers Approve Measure To Block Voters From Being Able To Legalize Marijuana

The Idaho House passed a resolution on Wednesday seeking voter approval to amend the state constitution and give the Legislature exclusive authority to regulate marijuana.

House Joint Resolution 4 aims to eliminate voters’ ability to legalize marijuana through a ballot initiative. As a resolution, the legislation does not hold the force of law. Instead, it would place a question on Idahoans’ ballot about whether to amend Idaho’s Constitution to allow only the Legislature to have a say in legalizing “psychoactive substances.” A majority of voters would need to vote yes in order for the constitution to be amended.

Currently, a “Decriminalize Cannabis Now” ballot initiative is in the signature gathering process, according to VoteIdaho.gov. If it qualifies, and if the Senate approves House Joint Resolution 4, then both questions would appear on the 2026 ballot, sponsor Rep. Bruce Skaug, R-Nampa said.

Skaug said the resolution comes from a place of concern for the “virtue and sobriety” of Idahoans.

“It’s time for Idahoans to proactively decide the state’s fate relative to marijuana, psychoactive substances and narcotics,” Skaug said. “I’m asking that we let our state go on the offense.”

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Marijuana Consumers Are Under Attack In Multiple States, And It’s Time To Fight Back

Seventy percent of Americans, including majorities of Democratic and Republican voters, say that marijuana should be legal for adults. Yet this legislative session, lawmakers from both parties are placing cannabis consumers in their crosshairs.

In Republican-led states like Montana, Nebraska, Ohio and South Dakota, lawmakers are seeking to either repeal or significantly roll back voter-approved legalization laws. In Democrat-led states like California, Maryland, Michigan and New Jersey, lawmakers are seeking to undermine existing legalization markets by drastically hiking marijuana-related taxes.

In all cases, elected officials are treating cannabis consumers as targets, not constituents.

These concerted attacks on state-legal marijuana markets are an explicit reminder that the war on cannabis and its consumers remains ongoing and, in some cases, is escalating. Our opponents haven’t gone away; in many cases they’ve simply regrouped and tweaked their strategies–such as by advocating for arbitrary THC potency caps or calling for new criminal penalties for consumers who don’t obtain their cannabis from state-licensed dispensaries.

Those who oppose legalization have also become bolder and more cynical in their tactics. No longer convinced that they can win the hearts and minds of voters, they are now frequently seeking to remove them from the equation altogether.

Earlier this year, Republican lawmakers in South Dakota sought to repeal the state’s voter-initiated medical cannabis access law, despite 70 percent of voters having approved it. The effort failed, but only by a single vote.

In Nebraska, lawmakers are also considering legislation to roll back that state’s voter-approved medical marijuana law and the state’s Republican attorney general has urged lawmakers to ignore the election results altogether.

In Ohio, GOP lawmakers in the Senate recently approved legislation to rescind many of the legalization provisions approved by voters in 2023. Changes advanced by lawmakers include limiting home-cultivation rights, imposing THC potency limits and creating new crimes for adults who share cannabis with one another or who purchase cannabis products from out of state.

In Texas, Republican Attorney General Ken Paxton has sued several cities, including Dallas, for implementing voter-approved ordinances decriminalizing marijuana possession. As a result, local lawmakers in various municipalities–including Lockhart and Bastrop–are ignoring voters’ decisions to rethink their marijuana policies rather than face potential litigation.

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U.S. Embassy Warns Americans Not To Use Traditional Psychedelics In Peru, Including Ayahuasca

The U.S. embassy in Lima, Peru, is warning Americans against a traditional psychedelic known as ayahuasca, cautioning that the mixture “is a psychoactive substance containing dimethyltryptamine (DMT), a strong hallucinogen that is illegal in the United States and many other countries.”

Officials argued that using ayahuasca or kambo—a psychoactive substance derived from some frogs—can cause negative health effects and increase risks of sexual assault, robbery and other hazards.

“These dangerous substances are often marketed to travelers in Peru as ‘ceremonial’ or ‘spiritual cleansers,’” embassy officials wrote in a late January health alert to U.S. citizens, adding: “Facilities or groups offering ayahuasca/kambo are not regulated by the Peruvian government and may not follow health and safety laws or practices.”

As for ayahuasca—a mixture of botanical ingredients that contains DMT—the alert says the substance “can cause several negative health effects, including nausea, vomiting, increased heart rate, and even death.  Some of the long-term effects include psychosis, difficulty sleeping, neurological diseases, and ongoing hallucinations.”

“In 2024, several U.S. citizens died or experienced severe illness, including mental health episodes, following consumption of ayahuasca,” it continues. “These incidents often occur in remote areas near or within the Peruvian Amazon, far away from modern medical facilities. The limited connectivity and limited access to emergency services and hospitals increases the risks.”

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Medical Marijuana Provides ‘Significant Improvements’ In Cancer Symptoms, Study Shows

A new study of medical marijuana patients in Minnesota finds that people with cancer who used cannabis “report significant improvements in cancer-related symptoms.” Nevertheless, it notes that the high cost of marijuana can be burdensome to less financially stable patients and raise “questions about affordability of and access to this therapy.”

The report, published late last month in the journal Cannabis, looked at 220 responses to a survey of patients with cancer enrolled in the Minnesota Medical Cannabis Program.

In addition to asking questions about patients’ cancer histories, cannabis use and symptom changes, the survey also included sociodemographic questions.

Results showed that while “the overwhelming majority” of patients reported symptom improvement associated with medical marijuana use, “individuals not living comfortably on their present income had higher monthly out-of-pocket costs for cannabis and were more likely to stop using cannabis or use it less than they would like; and this group more often cited cost as a reason for cannabis use disruptions.”

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