Research on the use of marijuana components to aid weight loss found that use of a combined product containing the cannabinoids THCV and CBD “was associated with statistically significant weight loss” as well as a slimmer waistline, lower blood pressure and decreased cholesterol.
The study, published late last month in the journal Cannabis, analyzed outcomes among 44 people who were administered either oral strips containing a mixture of the two cannabinoids or a placebo. Participants took one strip daily for 90 says and were evaluated for weight loss and certain metabolic markers.
“Use of the THCV/CBD strip was associated with statistically significant weight loss, decreases in abdominal girth, systolic blood pressure, and total and LDL cholesterol,” says the report, authored by Dr. Gregory Smith, the founder and CEO of plant-based medicine company NeX Therapeutics, based in Florida.
Participants—31 of whom were female and 13 of whom were male, with a combined average age of about 52 years—were given either a placebo or one of two different mucoadhesive oral strips. A lower-dose version contained 8 milligrams of THCV and 10 mg CBD, while a higher-dose version had 16 mg THCV and 20 mg CBD. Subjects received a reminder to take a dose each day on an empty stomach and report any side effects, and they agreed to refrain from using cannabis or other cannabinoid-based products.
Participants were not asked to make any changes to their diet or exercise routines.
Of 24 people who received the lower-potency oral strips, 16 (66.7 percent) demonstrated weight loss over the course of the 90-day period—on average losing 2.6 kilograms (5.7 pounds). Among the 10 who received the higher-dose strips, seven (70 percent) lost weight—an average of 4.1 kg (9.0 lbs).
The 10 subjects who received the placebo, meanwhile, lost an average of just 0.1 kg (0.2 lbs).
Nearly all (95.8 percent) in the lower-dose group also saw reductions in abdominal girth, as did 70 percent of the higher-dose subjects.
“It is interesting to note that there was a barely statistically significant decrease in the control/placebo group,” Smith wrote, “however, it is also worth noting that abdominal girth is probably the least accurate of all the biometric measures taken for the purposes of this study.”
The THCV/CBD groups also showed reductions in systolic blood pressure as well as total and LDL cholesterol, the research found.
“In summary, 90 day use of once-daily THCV and CBD-infused mucoadhesive strips was associated with clinically significant weight loss, decreases in abdominal girth, systolic blood pressure, and total and LDL cholesterol,” the report concludes, adding that stronger dosage appeared to perform better: “The 16mg/20mg daily dose in Group B was superior for weight loss compared to the 8mg/10mg daily dose in Group A.”
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