A new review of scientific research on the use of marijuana’s components to treat autism spectrum disorder (ASD) finds that “preliminary evidence suggests potential benefits,” including improvements around anxiety, sleep and behavior. But more work—especially randomized controlled trials—are needed “to confirm these results and establish clear treatment guidelines,” authors said.
“Preliminary findings suggest that CBD-rich formulations may provide modest benefits for sleep and social interaction, with a reduction in anxiety symptoms,” says the peer-reviewed study, published in the journal Cureus. “Regarding core ASD symptoms and behavioral outcomes, cannabinoids demonstrated greater efficacy compared to placebo in some studies.”
Researchers also acknowledged that “adverse events varied” among patients, and “response to treatment was inconsistent across individuals,” underscoring the need for further study.
“While cannabinoids, particularly CBD-rich formulations, appear to be relatively safe and potentially beneficial,” the new paper says, “further large-scale, controlled trials comparing CBD to established ASD treatments are essential to clarify its role and long-term impact in ASD management.”
The 13-person team behind the new study includes researchers from various hospitals and universities in Brazil.
Overall, they wrote, “While preliminary evidence suggests potential benefits, particularly for anxiety, sleep, and behavior, the findings remain inconclusive due to study heterogeneity and methodological limitations.”
For the analysis, authors looked at seven studies involving 494 patients, focusing on “key clinical outcomes, such as sleep, autistic core symptoms, anxiety, behavior, social effects, and adverse events.”
“Improvements were noted in anxiety, sleep quality, social effects, and behavior, although these findings varied across studies,” they concluded. “Importantly, adverse events were generally mild and occurred at similar rates in cannabinoid and placebo groups, supporting the intervention’s safety profile.”
Studies also indicated “a slight improvement” in sleep quality, while “autistic core symptoms showed positive responses” the report says. “Some studies also reported reductions in hyperactivity, agitation, self-injurious behavior, and epilepsy, along with improvements in communication skills, attention, and eye contact.”
Drowsiness was the most common side effect, followed by decreased appetite, weight loss, anxiety and restlessness.
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