Medical cannabis shows potential to fight cancer, largest-ever study finds

The largest ever study investigating medical cannabis as a treatment for cancer, published this week in Frontiers in Oncology, found overwhelming scientific support for cannabis’s potential to treat cancer symptoms and potentially fight the course of the disease itself.

The intention of the analysis was to solidify agreement on cannabis’s potential as a cancer treatment, said Ryan Castle, research director at the Whole Health Oncology Institute and lead author of the study. Castle noted that it has been historically difficult to do so because marijuana is still federally considered an illegal Schedule I narcotic.

“Our goal was to determine the scientific consensus on the topic of medical cannabis, a field that has long been dominated by a war between cherrypicked studies,” Castle said.

The study was funded by Cancer Playbook, which works with the Whole House Oncology Institute to collect, analyze and share data on patient-reported outcomes.

While research restrictions on Schedule I substances severely hamper clinical research on cannabis in humans, there is a large body of observational studies on medical cannabis and cancer – as well as lab research – that looks at cannabis’s effect on tumors in test tubes and in animals. The analysis included as many of those studies as possible.

“In order to move beyond bias – conscious or not – it was essential to use a large-scale, radically inclusive methodology based on mathematical reasoning,” Castle said, adding: “We wanted to analyze not just a handful, but nearly every major medical cannabis study to find the actual points of scientific agreement.”

Castle’s study looked at more than 10,000 studies on cannabis and cancer, which he said is “10 times the sample size of the next largest study, which we believe helps make it a more conclusive review of the scientific consensus”.

To analyze the massive quantity of studies, Castle and his team used AI – specifically, the natural language processing technique known as “sentiment analysis”. This technique allowed the researchers to see how many studies had positive, neutral or negative views on cannabis’s ability to treat cancer and its symptoms by, for example, increasing appetite, decreasing inflammation or accelerating “apoptosis”, or the death of cancer cells.

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North Carolina Lawmakers File Bill To Legalize Medical Marijuana For Patients With Debilitating Conditions

A new bill in the North Carolina House of Representatives would legalize medical marijuana for patients with a variety of specified conditions, including cancer, epilepsy, HIV/AIDS, Parkinson’s disease, PTSD, end-of-life care and other serious ailments.

The measure, HB 1011, was filed on Tuesday by Rep. Aisha Dew (D) and has been cosponsored by several other Democratic lawmakers.

The 28-page bill, titled the North Carolina Compassionate Care Act, is considerably more detailed than a separate Democrat-led medical marijuana bill introduced this week that would allow access only for patients enrolled in a “registered research study.”

Advocates have been awaiting House introduction of a comprehensive bill, especially since Senate President Phil Berger (R) said his chamber is deferring to the House to move first on medical marijuana reform this session.

“Glad to finally see a real medical cannabis bill get introduced,” Kevin Caldwell, Southeast legislative manager for the advocacy group Marijuana Policy Project, told Marijuana Moment in an email Wednesday.

The new bill, HB 1011, appears to be based largely on an earlier medical marijuana proposal from Sen. Bill Rabon (R), SB 3, filed in the 2023–2024 legislative session. That measure passed the Senate but failed to advance in the House due to an informal rule that requires a majority of the chamber’s GOP caucus to support a bill in order to bring it to the floor.

Caldwell at MPP said he would have liked to see the new House medical marijuana bill be sponsored by a Republican, which he reasoned would increase its chances of being heard in the GOP-controlled body. But he added that “legislators have known a medical bill has been in the works, and I hope they take this opportunity to provide relief to the tens of thousands of North Carolinians who are suffering from debilitating conditions.”

The new measure says in its findings section that “medical research has found that cannabis and cannabinoid compounds are effective at alleviating pain, nausea, and other symptoms associated with several debilitating medical conditions.” A majority of states and four of five U.S. territories have already legalized medical marijuana, it continues, and “North Carolina now takes similar action to preserve and enhance the health and welfare of its citizens.”

Under the proposal, the new medical cannabis program would be overseen by the state Department of Health and Human Services (DHHS).

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Arkansas GOP Governor Vetoes Bill To Allow Drive-Thru Medical Marijuana Sales At Dispensaries And Ease Delivery Rules

The Republican governor of Arkansas has vetoed a bill that would have allowed medical cannabis sales at drive-thru windows at dispensaries, while also easing certain rules around marijuana delivery services for patients and caregivers.

After the legislation from Rep. Aaron Pilkington (R) narrowly advanced through the legislature, Gov. Sarah Huckabee Sanders (R) returned the measure with a veto message on Wednesday.

“This legislation would expand access to usable marijuana, therefore I am vetoing this legislation,” Sanders said.

Under the bill, licensed dispensaries would be have been authorized to “deliver usable marijuana to a qualified patient or designated caregiver via a drive-through window located at the dispensary,” the text says.

People would have needed to place an online order and pick up their products on the same day of the transaction.

The measure also would have revised existing statute to allow visitors to tour dispensaries in additional to cultivation facilities. And it would have made it so conventional medical cannabis deliveries could be handled by one employee, instead of the current minimum of two, if additional security measures were taken.

The governor didn’t address any of the specifics of the bill, instead simply voicing opposition to the idea of expanding access to cannabis.

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CBD Helped Relieve Chronic Pain In More Than 98% Of Patients, Newly Published Study Finds

The marijuana component CBD can help patients manage chronic pain even at low dosages, making it “a promising alternative to conventional pain management strategies,” according to new research.

The peer-reviewed study, published in the journal Cureus, drew from responses to a survey posted on social media and in multiple medical clinics. Key findings, authors wrote, “are that the use of cannabinoids is positively associated with decreased chronic pain, even at low dosages (<100 mg).”

Most patients reported no side effects, while those who did reported only mild effects, the report says. No severe side effects were reported.

“These findings suggest that CBD may serve as a promising alternative to conventional pain management strategies,” the study concludes. “We believe these data point the way for new and continued avenues of research that can better optimize treatment regimens and help patients with chronic pain.”

The survey included 121 adults aged 21 and older who self-reported as having chronic pain, defined as pain lasting six months or longer. Questions involved demographics, patients’ perceptions of CBD’s effectiveness, dosage, frequency of use and side effects.

Authors wrote that they set out “to further explore this topic and add to the literature with the aim of asking chronic pain patients who use CBD for pain relief about their perceived benefits and side effects of CBD.”

Respondents were an average age of 37 years, and 61.2 percent were male. Most—100 people—said their pain had lasted two years or longer, while 21 said their pain had lasted 23 months or less.

As for causes of pain, the most common were arthritis (15.7 percent), disc herniation (14.9 percent), fibromyalgia (7.4 percent), headache or migraine (6.6 percent) and neuropathy (6.6 percent). Participants could select multiple responses.

Subjects were asked to rate their baseline level of chronic pain before CBD use on a scale from 1 to 10, as well as their pain level after beginning treatment.

“The average baseline level of chronic pain across participants before CBD was 5.4 ± 1.8,” the report says, “which decreased to 2.6 ± 1.7 (p < 0.0001, n = 121) after CBD, which is a decrease of 2.8 ± 1.7.”

Improvement was reported by 98.3 percent of subjects, while the remainder (1.7 percent, or two participants) reported no improvement at all. Three subjects “reported complete resolution of their baseline chronic pain after CBD,” according to the research.

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Largest-Ever Analysis Of Medical Marijuana To Treat Cancer Symptoms Shows ‘Overwhelming Scientific Consensus’ On Benefits

Researchers this week published what they described as the “largest meta-analysis ever conducted on medical cannabis and its effects on cancer-related symptoms”, finding “overwhelming scientific consensus” on marijuana’s therapeutic effects.

The study, published in the journal Frontiers in Oncology, analyzed data from 10,641 peer-reviewed studies—what authors say is more than ten times the number in the next-largest review on the topic. Results “indicate a strong and growing consensus within the scientific community regarding the therapeutic benefits of cannabis,” it says, “particularly in the context of cancer.”

Given what the report calls a “scattered and heterogenous” state of research into the therapeutic potential of marijuana, authors aimed to “systematically assess the existing literature on medical cannabis, focusing on its therapeutic potential, safety profiles, and role in cancer treatment.”

“We expected controversy. What we found was overwhelming scientific consensus,” lead author Ryan Castle, head of research at Whole Health Oncology Institute, said in a statement. “This is one of the clearest, most dramatic validations of medical cannabis in cancer care that the scientific community has ever seen.”

The meta-analysis “showed that for every one study that showed cannabis was ineffective, there were three that showed it worked,” the Whole Health Oncology Institute said in press release. “That 3:1 ratio—especially in a field as rigorous as biomedical research—isn’t just unusual, it’s extraordinary.”

The institute added that the “level of consensus found here rivals or exceeds that for many [Food and Drug Administration]-approved medications.”

“The strong consensus supporting the therapeutic use of cannabis, particularly in the context of cancer, suggests that there is a substantial scientific basis for re-evaluating cannabis’ legal status and its classification as a Schedule I substance,” researchers said in the paper.

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Florida Lawmakers Unanimously Approve Bill To Make Medical Marijuana Cards Free For Military Veterans

A Florida House panel on Tuesday unanimously approved a bill that would exempt military veterans from state registration fees for medical marijuana cards, allowing them to obtain the certifications for free.

The House Health and Human Services Committee advanced the legislation, HB 555 from Rep. Alex Andrade (R), on a vote of 21-0.

As originally filed, the measure would have made more significant changes to the state’s existing medical cannabis program, for example allowing home cultivation as well as reciprocity for out-of-state patients. But earlier this month the House Health Professions and Programs Subcommittee replaced its language with a two-page substitute that instead would make only small changes to the medical program.

First, it would change how often patients need to renew their medical marijuana cards, from the current annual process to once every two years.

Second, it would waive the $75 registration and renewal fees for veterans, specifying that the state “may not charge a fee for the issuance, replacement, or renewal of an identification card for a qualified patient who is a veteran.”

A handful of supporters testified ahead of the panel’s vote on Tuesday, and no one spoke against the measure.

Melissa Villar of Tallahassee NORML said that when Florida’s medical cannabis program launched, “it was the most expensive in the country for patients and for business entrance.” She asked lawmakers to expand the bill to go beyond helping military veterans and to additionally provide for discounted or cost-free patient cards for people who are disabled or low income.

If HB 555 becomes law, the changes would take effect July 1.

Separately, House and Senate lawmakers are considering legislation that would outlaw fungal spores that produce mushrooms containing psilocybin or psylocin.

The proposed ban on spores of mushrooms that create psilocybin or psilocin is part of the roughly 150-page bills, which would make a variety of adjustments to Florida’s agricultural laws, including around agricultural lands, utilities and wildlife management.

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Pennsylvania Lawmakers Push To Protect Medical Marijuana Patients In Child Custody Cases After Father Loses Rights Over THC Test

Pennsylvania lawmakers are taking action to clarify that a person’s status as a medical marijuana patient cannot be used against them in parental custody rulings in family court.

While state statue clearly stipulates that lawful use of medical cannabis “shall not by itself be considered by a court in a custody proceeding,” a father’s recent experience losing custody rights after testing positive for THC metabolites has exposed an apparent implementation issue.

After David Levi—a registered medical cannabis patient with severe arthritis—sought financial support from his daughter’s mother in family court, his use of marijuana became a determining factor, contrary to what’s prescribed under state law.

“By the time they were done with me, I became a drug user—not a prescribed user—and that’s my tagline” in the eyes of the court, Levi told Marijuana Moment. “And two days before my father died, I got an email, and it was that the judge had ordered to take away all of my rights as a father.”

“I went from 50-50 custody to not being able to drive my daughter, and I’m only allowed to have overnight visits with her every other week,” he said.

Sen. John Kane (D) learned about his constituent’s story and, last week, circulated a cosponsorship memo to build support for forthcoming legislation to both clarify the existing statute and also make it so a person’s medical cannabis patient status cannot be used to determine child custody or to justify a drug test in a custody case.

“To treat his pain without using addictive opioids, my constituent obtained a medical marijuana card and began using this medication to treat his arthritis,” Kane wrote. “Medical marijuana has allowed him to manage his pain, maintain his work, and remain an attentive father to his three-year-old daughter.”

“Despite following the guidelines set forth by Pennsylvania’s Medical Marijuana Act, the constituent found himself in a custody battle that has threatened his rights as a father and penalized him based on his status as a medical marijuana patient,” he said, adding that current statute “prohibits the lawful use of medical marijuana as a determinant of child custody.”

“However, in my constituent’s case, his use of medical marijuana was used against him to determine child custody,” the senator said. And to address the issue, he will be filing legislation to “amend Title 23 Section 5328 to prohibit the use of medical marijuana from being used to determine child custody or the sole reason to order a drug test in child custody cases.”

The text of the bill hasn’t been filed yet. But on the House side, a Republican lawmaker has since committed  to work on the issue as well, Levi said.

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New North Carolina Bill Would Legalize Medical Marijuana For Patients Enrolled In A ‘Registered Research Study’

A newly filed bill in North Carolina would narrowly legalize medical marijuana, allowing access for individuals enrolled in a “registered research study.”

Titled the Cannabis Treatment Research Act, HB 984 would allow patients and caregivers to register with the state, which in turn would permit legal possession of up to 1.5 ounces of marijuana. It’s sponsored by Rep. Julia Greenfield (D) and five other Democratic lawmakers.

The three-page bill would create a Cannabis Treatment Research Database under the Department of Health and Human Services (DHHS). To qualify for the program, patients would need to be enrolled in a study conducted by a hospital, university, lab, pharmaceutical manufacturer or private medical research company that is registered with DHHS and has entered a study into the state research database.

The legislation specifies no age limit for patients, but registered caregivers would need to be at least 18. As for qualifying conditions, it lists no specific maladies but mandates that patients obtain a signed statement from “a physician with whom the patient has a bona fide physician-patient relationship indicating that, in the physician’s professional opinion, the patient has a medical condition and the potential health benefits of the medical use of cannabis would likely outweigh the health risks for the patient.”

It’s not immediately clear how accessible the research-focused program would be in practice, though it appears that authors intend the program to be relatively open.

The measure states, for example, that it’s the General Assembly’s intent “that any physician who issues a written certification to a patient be permitted to participate in objective scientific research.” It also defines research broadly to include “the development of quality control, purity, and labeling standards for cannabis; sound advice and recommendations on the best practices for the safe and efficient medical use of cannabis; and analysis of genetic and healing properties of the many varied strains of cannabis to determine which strains may be best suited for a particular medical condition or treatment.”

In addition to legalizing possession among registered patients and caregivers, the bill shields from liability both research institutions and their employees. It also specifies that the identities of patients, caregivers and research institutions be shielded from public record, though in some cases it allows records to be provided to law enforcement.

The Democrat-led measure was introduced on Thursday in the House of Representatives. Lawmakers—including Senate President Phil Berger (R)—have said they’re deferring to the House on medical marijuana reform this session, but it’s not clear whether HB 984 is the only bill that will be introduced in that chamber.

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Montana Lawmakers Pass Marijuana Bill To Set Zero-Tolerance THC Limit For Drivers Under 21

Advocates are warning that a bill passed by Montana’s legislature aimed at reducing marijuana-impaired driving by people under 21 would put younger medical cannabis patients at risk and criminalize minors who may have used the drug days earlier but are otherwise entirely sober.

The state House of Representatives voted on Friday to pass the measure—SB 508, from Sen. Willis Curdy (D)—which the Senate approved in early March. It next proceeds to the desk of Gov. Greg Gianforte (R).

Reform advocates are asking their supporters to urge a veto from the governor, noting that the proposal includes mandatory jail time for offenders and claiming that young drivers could be tested and charged after an accident that wasn’t their fault even if they weren’t impaired.

The Marijuana Policy Project (MPP) said in an email about the bill that it would create an “extreme standard for drivers under 21, making it a DUI offense to have any detectable THC or certain metabolites in their system.”

“It would criminalize sober young drivers who are state-legal medical cannabis patients, people who tested positive after using legal CBD products, and people who were exposed to cannabis second-hand,” the group said. “Since THC can remain in the bloodstream and urine days after its effects have worn off, this approach would criminalize and incarcerate young Montanans who are completely unimpaired.”

Karen O’Keefe, director of state policies for MPP, said the House passed the bill after lawmakers made misleading statements about marijuana legality among people younger than 21 as well as circumstances under which minors would be tested.

In floor debate, Rep. Steven Kelly (R) said that marijuana use is already illegal for people under 21 and that minors would need to exhibit signs of impairment—such as bloodshot eyes or inhibited speech—in order to be tested.

But MPP points out that Illinois’s medical marijuana program allows patient use by people 21 and under with a doctor’s recommendation, and minors can also legally use hemp-based CBD products that in some cases can cause positive THC tests, especially when screening for trace amounts.

The group also noted that nothing in the bill appears to actually require evidence of impairment, meaning drivers could be tested even if there’s no sign they’re actually under the influence of the drug.

“There is no need for this unjust, overbroad law,” MPP said in its email, adding that “Montana already criminalizes impaired driving,” including with a per se THC blood limit of 5 nanograms per milliliter.”

MPP also put out a call to action asking supporters to urge Gianforte to veto SB 508.

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Kansas Governor Says It’s Time For Lawmakers To ‘Finally Legalize Medical Marijuana’

Kansas Gov. Laura Kelly (D) says it’s time for lawmakers in the state to finally legalize medical marijuana.

The governor called for the reform on Wednesday, as she allowed a separate right-to-try bill to become law without her signature. That measure is intended to give people with debilitating or life-threatening conditions broader access to experimental medications.

“This bill gives Kansans with debilitating disease the option to make choices about their medical care,” Kelly said in a statement about the bill, SB 250. “Now I think it’s time for the Legislature to finally legalize medical Marijuana, giving the Kansans suffering from chronic pain or Post Traumatic Stress Disorder, and children suffering with Dravet’s Syndrome (epilepsy) the choice of the treatment they and their doctors determine best suits their needs.”

Notably, lawmakers earlier this year considered but ultimately rejected an amendment that would have added cannabis to the right-to-try bill. The lawmaker behind that effort, Sen. Cindy Holscher (D), said her intention was not to create a public medical marijuana system, however.

Sen. Mike Thompson (R) disparaged the idea at the time. “The term medical cannabis is nothing but a marketing ploy,” he said.

Polling from late last year shows that nearly three quarters (73 percent) of Kansans support legalizing medical marijuana. About six in 10 (61 percent) respondents also said they supported legalizing cannabis for broader adult use.

Legislators have nevertheless repeatedly shot down reform efforts.

The House of Representatives passed a medical cannabis bill in 2021, for example, but it stalled out in the Senate. And after numerous hearings on the issue, the Senate Federal and State Affairs Committee voted last March to table a limited medical marijuana pilot program bill.

A later effort to revive the medical cannabis bill on the Senate floor ultimately fell short.

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