Study: Patients Less Likely To Have Suicidal Thoughts Following Medical Cannabis Use

Patients prescribed cannabis-based medicinal products (CBMPs) report decreases in the prevalence and intensity of suicidal thoughts, according to observational data published in the journal Archives of Suicide Research.

British investigators assessed rates of suicidal ideation in a cohort of patients authorized to use botanical cannabis or oil extracts. (British physicians are permitted to prescribe cannabis-based medicinal products to patients who are unresponsive to conventional medications.)

Researchers reported, “Three months after commencing treatment, there was a reduction in both the percentage of the sample reporting suicidal ideation and the mean severity of suicidal ideation. … Twelve-month follow-up indicated a substantial reduction in depressed mood with this reduction being more pronounced in those reporting SI [suicidal ideation at baseline.]”

The study’s authors concluded: “To the best of our knowledge, this is the first observational study of CBMPs to report on rates of suicidal ideation. … The current findings suggest CBMPs may be effective in reducing suicidal ideation, as well as other facets of health and well-being … while also suggesting that the presence of suicidal ideation should not be used as a reason to exclude an individual from CBMPs treatment.”

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Federal Judge In Texas Rules That Ban On Gun Ownership By Marijuana User Is Unconstitutional As Applied

A federal judge in El Paso has ruled that the U.S. government’s ongoing ban on gun ownership by habitual marijuana users is unconstitutional in the case of a defendant who earlier pleaded guilty to the criminal charge. The court this week allowed the man to withdraw the plea and ordered that the indictment against him be dismissed.

The new ruling stops short of declaring that the law against firearm ownership by cannabis users—18 U.S.C. § 922(g)(3)—is itself unconstitutional. As applied to the defendant in the case, however, it says that government lawyers failed to demonstrate that the restriction aligns with the nation’s history of regulating gun ownership, noting that that they did “nothing in the way of proving that Defendant was intoxicated by marijuana at the time of this incident.”

David Briones, a senior U.S. District Court judge for the Western District of Texas, also acknowledged in the decision that the legal landscape around marijuana and the Second Amendment had evolved since the court first accepted the guilty plea. In the interim, the U.S. Court of Appeals for the Fifth Circuit, which includes Texas, ruled that while “some limits on a presently intoxicated person’s right to carry a weapon” may be constitutional, “disarming a sober person based on past substance usage” is not.

That case, U.S. v. Daniels, was set to be considered by the U.S. Supreme Court earlier this year but was among a number of firearms-related cases remanded back to lower courts following a separate Supreme Court decision about firearms and domestic violence.

“In the past two years alone,” Briones, a Clinton appointee, wrote in the new ruling, “the Fifth Circuit and the United States Supreme Court have heard and considered the following cases: DanielsRahimi, and Bruen. These cases have changed the law when it comes to the Second Amendment, and in the case of Daniels, have challenged the constitutionality of the very statute under which Defendant is charged.”

In the case, the El Paso Police Department responded to a 2021 call at the defendant’s home, entered the house and found two bags of marijuana. A search also found multiple guns inside the home. The defendant allegedly told officers that he’d used marijuana regularly for years and understood it was illegal to have both a medical marijuana card and a gun.

After the guilty plea, the defendant appealed his case to the Fifth Circuit, which later remanded it back to the district court in light of the recent precedent-setting opinions.

“This court now has a fuller picture of the Second Amendment jurisprudence as it stands today,” the order says, “and has reconsidered its position.”

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CBD Is A ‘Promising Candidate’ For Treating Depression With ‘Few Side Effects,’ New Scientific Review Concludes

A new scientific review says there’s “accumulating” evidence that the marijuana component CBD “has antidepressant properties in humans and animals with few side effects” and may also aid in the reduction of inflammation and formation of new brain cells.

“In summary,” says the manuscript, newly accepted by the International Journal of Neuropsychopharmacology, “there is growing evidence that CBD may be a promising candidate for the treatment of depression.”

The review notes that while the anti-depressant effects of the cannabinoid have been previously reported, the mechanisms of action behind those effects are still poorly understood. “Therefore, this paper reviews the molecular targets, pharmacokinetics, and safety of CBD,” it says.

Authors from the departments of pharmacology at Nantong University, the First People’s Hospital of Yancheng and the Jiangyin Hospital of Traditional Chinese Medicine—all in Jiangsu, China—looked at recently published papers on experimental and clinical studies around CBD, concluding that effects seem to be linked to the cannabinoid’s role in reducing inflammation and enhancing neurogenesis.

As for the cannabinoids’ targets in the human body, authors wrote that “receptor mechanisms underlying CBD’s effects are very complex and involve in multiple receptors including CB1, CB2, GPR55, 5-HT1A, and PPARγ receptors.”

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Kentucky Residents Who Participate In State’s New Medical Marijuana Program Will Be Ineligible To Own Guns, Feds Warn

The federal Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF) is warning Kentucky residents that, if they choose to participate in the state’s medical marijuana program that’s set to launch imminently, they will be prohibited from buying or possessing firearms under federal law.

As Kentucky prepares to implement the medical cannabis law that Gov. Andy Beshear (D) signed last year, ATF has put residents on notice about the ongoing federal ban on gun ownership by people who use marijuana, regardless of individual state policies.

“You cannot possess firearms and ammunition and also be a user of marijuana,” ATF Special Agent AJ Gibes told WDRB this month, referring to a statute requiring gun purchasers to fill out a form that includes a question about whether they are an active marijuana consumer. If they check yes, they’re disqualified from owning the firearm.

Notably, Gibes said that while people who already own a gun aren’t “expected to” turn them over if they become state-legal cannabis patients, those who “wish to follow federal law and not be in violation of it” must “make the decision to divest themselves of those firearms.”

He added that ATF is “not actively seeking and working solely on investigations involving just the possession of firearms and marijuana because of our finite resources,” but that doesn’t change the law, and people will still be at risk of prosecution if they violate it.

ATF has also weighed in on other recent state cannabis policy developments.

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Top Indiana GOP Lawmakers Oppose Medical Marijuana Even As Incoming Republican Governor Says It’s Time To Legalize

On the heels of a survey showing nearly 9 in 10 Indiana adults support legalizing medical marijuana—and comments from Gov.-elect Michael Braun (R) that “it’s probably time” to allow access to therapeutic cannabis—Republican leaders in the state legislature are pushing back on the idea.

“It’s no secret that I am not for this,” Senate President Pro Tem Rodric Bray (R) said during a panel at a law firm event in Indianapolis on Wednesday. “I don’t have people coming to me with really compelling medical cases as to why it’s so beneficial. And any state that I’ve seen pass medical marijuana is essentially passing recreational marijuana.”

House Speaker Todd Huston (R), meanwhile, doubted any medical benefits associated with marijuana, calling the substance “a deterrent to mental health.” He and others suggested that lawmakers supportive of the reform merely want to boost state revenue.

“I don’t believe public policy should ever be built based off revenue,” Huston said. “On any public policy, I don’t think you should chase revenue.”

Bray, who said he has yet to hear a compelling case where medical marijuana has been beneficial, said that “the idea of passing a policy simply because of the revenue that it would generate is something that I inherently, completely disagree with.”

“If it’s a good policy, then do it,” he added, “and revenue may come from that. But the idea of doing it because of the amount of revenue [it would generate] is really, really bad policy in my perspective.”

One Democrat on the panel, Senate Minority Leader Greg Taylor, said that he believes Indiana is falling behind other nearby states that have already legalized medical marijuana. Republican panelists disagreed.

“I’m not sure we’re behind,” Huston shot back. “If we are behind on having fewer people using an addictive substance, I don’t know, I’m OK with that.”

The comments, made at the annual Dentons Legislative Conference, were first reported by State Affairs.

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Marijuana Terpenes Relieve Post-Surgery And Fibromyalgia Pain, Study Shows

New government-funded research on terpenes produced by the cannabis plant finds that some of the aromatic compounds could be promising therapeutics to help manage pain from fibromyalgia or during recovery from an operation.

The study, published this month in the journal Pharmacological Reports, involved administering four separate terpenes—geraniol, linalool, beta-caryophyllene and alpha-humulene—to mice that either underwent paw-incision surgery or had lab-induced fibromyalgia symptoms. Researchers then measured their “mechanical sensitivity” over the course of three hours to evaluate the terpenes’ possible effects on pain.

“These results demonstrate that the terpenes geraniol, linalool, β-caryophyllene, and α-humulene may be a viable medication for post-operative and fibromyalgia pain relief,” says the report, which was funded by a grant from the National Institutes of Health (NIH).

As for post-operative pain, each of the four studied terpenes “increased mechanical threshold significantly in comparison to the mice treated with the vehicle,” according to the research, referring to a solution without any terpenes that’s been previously shown not to have any pain-relieving effect. “Taken together, the data suggests that all 4 terpenes are efficacious in relieving post-surgical pain.”

All four terpenes also increased mechanical sensitivity in mice with fibromyalgia-like symptoms compared to mice treated with the vehicle alone, at least for some time points measured. Differences in mice treated with geraniol and linalool were statistically significant, while sensitivity in the mice treated with the other two terpenes was “elevated over vehicle but not statistically significant,” according to the report.

“These observations suggest that these four terpenes are also efficacious in a fibromyalgia pain model,” it says.

“This work further strengthens the case for the translational potential of Cannabis and its individual components to determine if they could be effective in relieving post-operative and fibromyalgia pain in patients while causing more tolerable side effects than current standard medications for these ailments.”

The current study, noted authors at the University of Arizona’s pharmacology department and Center for Pain and Addiction, is a continuation of their past research into the same four terpenes to treat other types of pain.

“Previously, we found the terpenes…to be effective in relieving CIPN [chemotherapy-induced peripheral neuropathy] and inflammatory pain in mice,” they wrote in the new report. “Their efficacy in other pain models, such as post-operative and fibromyalgia pain, had not yet been defined.”

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Portugal To Become The New ‘El Dorado’ Of Medical Cannabis in Europe

“We should be the new El Dorado of medical cannabis production,” said agronomist Jose Martins as dozens of workers harvested marijuana in bright sunshine at a farm in southeastern Portugal.

The country is fast becoming a European hub for medical cannabis, with its warm temperate subtropical climate — often compared to California’s — making it an ideal place to grow the plant.

“No other country in Europe has better environmental conditions,” Martins told AFP at the plantation, which is surrounded by razor wire and infrared cameras.

Set in hills near Serpa dotted with olive trees and cork oaks, the 5.4-hectare (13.3-acre) farm owned by the Portuguese pharmaceutical company FAI Therapeutic produces around 30 tonnes of cannabis flowers a year.

They set up two years ago after a flood of foreign cannabis producers were drawn to Portugal because of its favourable climate and legislation.

More than 60 companies are currently authorised to grow, produce or distribute medical cannabis products there, with 170 more having applied for permission.

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Florida Judge Sides With Paramedic Who Was Fired Over Legal Medical Marijuana Use

A Hillsborough County judge has ruled in favor of a paramedic and medical marijuana patient who was suspended by the Hillsborough County Fire and Rescue Department in 2019 after testing positive for cannabis use.

Judge Melissa Polo ruled on Tuesday that Hillsborough County is prohibited from discriminating against and must provide accommodations to employees with valid medical marijuana cards who test positive for the drug—as long as there is no evidence the employee was using illegal substances at work, on county property or in county vehicles, or reported to work under the influence.

She also ruled that the plaintiff, Angelo Giambrone, is entitled to  back pay, compensatory damages and attorney fees and costs associated with his case.

Florida’s medical marijuana statute does not require an employer to accommodate the medical use of marijuana in any workplace or any employee while working under the influence of marijuana but is silent about whether employers must accommodate off-site or off-work use of marijuana.

Officials with Hillsborough County issued a statement on Wednesday about the decision.

“Following the recent court ruling involving a former employee of Hillsborough County Fire Rescue and the use of medical marijuana, Hillsborough County is carefully evaluating possible next steps related to the case,” it said.

Democratic lawmakers have filed bills in recent sessions to give employees who are medical marijuana patients legal protections at work, although they haven’t moved in the GOP-controlled Legislature.

“It’s finally what I think the people voted for in 2016 for medically marijuana coming to fruition,” said Tampa attorney Michael Minardi, who defended Giambrone in court. “We think this is obviously a correct verdict and hopefully allow marijuana patients to stop being discriminated against when they’re using medicine so they can be functional human beings in life again.”

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Nebraska Judge Rejects Officials’ Move To Amend Medical Marijuana Ballot Challenges She Has Already Dismissed

A Lancaster County District Court judge has overruled two final attempts to amend legal challenges against Nebraska’s two medical cannabis petitions.

In a five-page order Thursday morning, District Judge Susan Strong denied requests from John Kuehn (R), a former state senator and former State Board of Health member who brought the initial lawsuit, and Nebraska Secretary of State Bob Evnen (R) to amend their complaints.

Strong said the amendments would not affect the outcome of the lawsuit that she had already dismissed last week, and for which she had already anticipated the legal arguments.

The dismissal upheld the ballot certification of two measures from the Nebraskans for Medical Marijuana campaign to legalize and regulate the drug. Voters passed the two measures, and state constitutional officers certified those election results Monday, including Evnen and Attorney General Mike Hilgers (R), whose office defended Evnen in the Kuehn-led lawsuit.

The medical cannabis laws to legalize and regulate the drug are set to take effect by December 12.

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Nebraska AG Prepares To Ask Supreme Court To Overturn Voter-Approved Medical Marijuana Measures

The Nebraska Attorney General’s Office filed a second “amended cross-claim” Friday on behalf of Secretary of State Bob Evnen (R) in a lawsuit against two successful medical cannabis measures.

The brief formally adds allegations of circulator fraud and widespread malfeasance to Evnen’s complaint. However, Lancaster County District Judge Susan Strong anticipated those arguments already last Tuesday when she dismissed the case and ruled in favor of the ballot sponsors behind Nebraskans for Medical Marijuana.

The AG’s Office has not formally filed an appeal to the Nebraska Supreme Court, but Attorney General Mike Hilgers (R) told the Nebraska Examiner on Monday that his office was “taking advantage” of court rules that allow a party to formally amend a cross-claim, even after a verdict, to conform to the evidence presented at trial.

“It’s just a post-trial motion,” Hilgers said Monday. “We want to make sure our case is fully prepared for an appeal.”

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