Prescription opioid shipments declined sharply even as fatal overdoses increased, new data shows

The number of prescription opioid pills shipped in the U.S. in the second half of the 2010s decreased sharply even as a nationwide overdose crisis continued to deepen, according to data released Tuesday.

The decline in painkiller prescriptions — finally dropping below the quantities sold in the mid-2000s when the overdose epidemic accelerated — happened after state and federal governments tightened prescribing guidelines and state, local and Native American tribal governments sued the industry over the toll of the addictive drugs.

“We are still at an epidemic proportion of pills,” Peter Mougey, a lawyer representing governments that are suing drugmakers, distribution companies and pharmacies, said in an online news conference to release the data Tuesday.

The distribution data is being released by lawyers after a judge ordered the U.S. Drug Enforcement Administration to share it with the plaintiffs. The governments assert that the companies should have done more to stop the flow of opioids when they saw that more than necessary were flowing to pharmacies and patients.

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$1bn in aid has been used to support failed ‘war on drugs’ over past decade, says report

Almost $1bn (£800m) of aid has been spent on a global “war on drugs” over the past decade that has fuelled human rights abuses, according to a new report.

Analysing data from the Organisation for Economic Co-operation and Development (OECD), the NGO Harm Reduction International (HRI) found that, between 2012 and 2021, the US and the EU spent $550m and $282m of their aid budgets respectively on programmes that supported drug control policies. The UK has spent $22m since 2012 – more than $10m of that in 2012 – which has been used to support surveillance capabilities in Colombia, Mozambique and the Dominican Republic, and undercover policing in Peru.

Under Joe Biden, the US has hugely increased the amount of aid spent on narcotics control from $31m in 2020 to $309m in 2021. Some of the money has been used by the Drug Enforcement Agency to train police and special units in Vietnam and Honduras, which have been accused of arbitrary arrests and killings.

The report found more aid globally was spent on supporting drugs policies ($323m) in 2021 than on school feeding projects ($286m) or labour rights ($198m). Ninety-two lower-income countries were listed as having received aid for narcotics control, including Afghanistan, which received money to train police after the Taliban takeover in 2021.

“When you think about development, you don’t really think about it being used for those kinds of activities – you think of poverty reduction, working towards development goals on health or education,” said Catherine Cook, sustainable financing lead at HRI, which monitors the impact of drug policies. “This money is actually being used to support punitive measures – so policing, prisons, essentially funding the ‘war on drugs’, even though we know the ‘war on drugs’ and punitive policies have repeatedly failed.”

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As more children die from fentanyl, some prosecutors are charging their parents with murder

Madison Bernard climbed into bed before dawn with her toddler, Charlotte, who was asleep next to a nightstand strewn with straws, burned tinfoil and a white powder.

Hours later, the mother woke and found her daughter struggling to breathe, according to investigators who described the scene in court documents.

After being rushed in an ambulance to a hospital, the 15-month-old girl died from a fentanyl overdose. Her mother and father, whom authorities said brought the drugs into their California home, were charged with murder and are awaiting trial.

The couple has pleaded not guilty but are part of a growing number of parents across the U.S. being charged amid an escalating opioid crisis that has claimed an increasing number of children as collateral victims.

Some 20 states have so-called “drug-induced homicide” laws, which allow prosecutors to press murder or manslaughter charges against anyone who supplies or exposes a person to drugs causing a fatal overdose. The laws are intended to target drug dealers.

In California, where the Legislature has failed to pass such laws, prosecutors in at least three counties are turning to drunk driving laws to charge parents whose children die from fentanyl overdose. It’s a unique approach that will soon be tested in court as the cases head to trial.

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San Francisco Drug Crisis: Feds Plan To Ramp Up Prosecutions

Federal prosecutors are planning to take a more aggressive approach to charging suspected drug dealers in San Francisco as the city grapples with record-high overdoses, according to sources familiar with the new plan.

Exact details are being held close to the vest, but officials for the U.S. Attorney’s Office, the Drug Enforcement Agency, the San Francisco District Attorney’s Office, the Office of Mayor London Breed and the San Francisco Police Department have been meeting for weeks in preparation of an official rollout that is expected to be formally announced in the next month. 

Abraham Simmons, a spokesperson for the U.S. Attorney’s Office, told The Standard that the plan is to prosecute more drug-dealing cases in federal court, describing it as the result of  intense coordination between local and federal officials.

“It’s all hands on deck,” Simmons said. 

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UN says Colombia’s coca crop at all-time high as officials promote new drug policies

Coca cultivation reached an all-time high in Colombia last year, the U.N. said, as the administration of President Gustavo Petro struggles to reduce poverty in remote areas and contain armed groups that are profiting from the cocaine trade.

The new findings on coca growing were published over the weekend by the United Nations Office on Drug and Crime, which said 230,000 hectares (nearly 570,000 acres) of farmland in Colombia were planted with coca in 2022, a 13% increase from the previous year.

The South American nation is the world’s largest exporter of cocaine, which is made from coca leaves. Colombia provides 90% of the cocaine sold in the United States each year.

Colombia’s government said Monday that the amount of land planted with coca is increasing at a slower pace than in previous years. It hopes new programs that provide greater economic incentives for farmers to adopt legal crops will help reduce cocaine production in coming years.

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14 GOP Congressional Lawmakers Tell DEA To Keep Marijuana In Schedule I And ‘Reject’ Top Health Agency’s Recommendation

A coalition of 14 Republican congressional lawmakers is urging the Drug Enforcement Administration (DEA) to “reject” the top federal health agency’s recommendation to reschedule marijuana and instead keep it in the most restrictive category under the Controlled Substances Act (CSA).

In a letter sent to DEA Administrator Anne Milgram on Monday, Sen. James Lankford (R-OK) and Rep. Pete Sessions (R-TX) led a dozen other colleagues in both chambers in arguing that any decision to reschedule cannabis “should be based on proven facts and science—not popular opinion, changes in state laws, or the preferred policy of an administration.”

Of course, the U.S. Department of Health and Human Services (HHS) has repeatedly emphasized that its review into marijuana scheduling, directed by President Joe Biden late last year, was science-based. And after 11 months of investigation, it has recommended that marijuana be placed in Schedule III. Milgram has also made clear that DEA’s review will follow the science.

The eight GOP senators and six House members evidently distrust the motives behind the HHS recommendation, however, and they argued in the letter, first reported by The Washington Stand, that the current “research, science, and trends support the case that marijuana should remain a Schedule I drug.”

They pointed to National Institute on Drug Abuse (NIDA) data on rates of cannabis use disorder and raised concerns about increased THC potency of marijuana products, stating that these “facts indicate that marijuana has a high potential for abuse and that the risk is only increasing.”  For what it’s worth, NIDA also reportedly signed off the HHS rescheduling recommendation before it was sent to DEA.

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Depressed by the War on Drugs? Magic Mushrooms May Help.

Hallucinogenic drugs like psilocybin-containing magic mushrooms are closely linked in the public imagination with hippies and pleasure-seeking. While there’s nothing inherently wrong with pleasure-seeking (we’ll see about hippies), growing evidence suggests that, properly used, these drugs may be just as effective for healing minds as they are at blowing them. A recently published study reports that, among other uses, psilocybin is a very effective treatment for depression.

“In a randomized, placebo-controlled, 6-week trial in 104 adults, a 25-mg dose of psilocybin administered with psychological support was associated with a rapid and sustained antidepressant effect, measured as change in depressive symptom scores, compared with active placebo,” according to the authors, led by Dr. Charles L. Raison of Wisconsin’s Usona Institute, of “Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial,” published in August in the Journal of the American Medical Association. “No serious treatment-emergent adverse events occurred.”

The trial, conducted at different locations between December 2019 and June 2022, included participants between ages 21 and 65 who had been diagnosed with major depressive disorder of at least 60 days’ duration. Half of the participants were given a 25-mg dose of psilocybin and the other half were given niacin as a placebo, administered in identical capsules. The patients were assessed at eight days (the original end point of the study) and then at 43 days (the extended time frame).

Over the course of the study, “a single 25-mg dose of psilocybin administered with psychosocial support was associated with clinically and statistically significant reductions in depressive symptoms and improvement in measures of functional disability compared with a 100-mg dose of niacin placebo administered under an identical protocol.” The researchers also found a higher rate of sustained remission from depression symptoms among those who received psilocybin, “but the difference was not statistically significant.”

Adverse events potentially related to psilocybin consumption included one reported migraine, a headache, and one participant experiencing panic attack and paranoia. Nothing similar was found among the placebo group. As side effects go, that’s pretty mild and comparable to those linked to commonly used antidepressant drugs. Hence the finding that the study resulted in “no serious treatment-emergent adverse events.”

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Canadian Study Links Cannabis Legalization to an Increase in Car Accidents

The results of a recent study published in JAMA Network Open claim to have found an association between cannabis legalization and an increase in traffic accidents.

The study was conducted by researchers at the University of Ottawa and looked at emergency room visits in Ontario, Canada over a 13-year period (Jan 2010-Dec 2021 which is actually 12 years but they say 13 in the study so what do I know), at the end of which they denoted a 475.3% increase in traffic accidents that resulted in an emergency room visit in which the driver had cannabis in their system at the time of the accident.

“This cross-sectional study found large increases in cannabis involvement in ED visits for traffic injury over time, which may have accelerated following nonmedical cannabis commercialization,” the conclusion of the study said. “Although the frequency of visits was rare, they may reflect broader changes in cannabis-impaired driving. Greater prevention efforts, including targeted education and policy measures, in regions with legal cannabis are indicated.”

At first glance, 475.3% sounds like a big number and suffice it to say many of the anti-cannabis media outlets who repackaged that number for a scary-sounding headline are counting on their readership to look no further and take their word for it that cannabis legalization and car crashes must be associated. I’m a journalist, not a scientist, but I am able to point out some facts about the study that might make that big number seem a bit less scary.

For one thing the study was only conducted in Ontario, Canada. In terms of sample size, that is one city in a country with very specific cannabis laws so to lay the blanket term “legalization” over one very specific set of laws isn’t totally accurate. The study even says so in the introduction:

“Another study also found no increase in total traffic injury hospitalizations in Canada over 2.5 years following legalization. Critically, the slow rollout of the cannabis retail market in Canada and the overlap of the legalization period with the COVID-19 pandemic greatly reduces the ability of these studies to evaluate the impacts of legalization,” the study said.

It’s also important to understand that the total number of injury-causing traffic accidents involving cannabis in the 13-year period came to a grand total of 426 out of 947,604. That number as a percentage is .04%, which is even smaller when compared to the total number of traffic accidents without taking emergency room visits into account. It’s hardly insignificant, but it is, arguably, a much less daunting number at first glance than 475.3%.

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Pennsylvania Officials Won’t Give Medical Marijuana Patients Access To Edibles—For Now

Officials tasked with monitoring the state’s medical marijuana program said this week edibles don’t belong in Pennsylvania’s marketplace.

Concerns about safety, efficacy and legal enforcement gave members of the Medical Marijuana Advisory Board pause. Six abstained from voting on the recommendation at all during its Wednesday meeting. Only two members supported the proposal, while two more rejected it.

The vote came after a discussion about the growing popularity of “troches,” an ingestible form of THC that resembles a cough drop. Dispensaries market the product alongside tinctures, which users absorb sublingually.

Supporters say some patients dislike the respiratory and digestive side effects that come from other forms of medical marijuana, including vaping cartridges, flowers, pills, and concentrates. Edibles offer a viable alternative.

Critics argue, however, that traditional edibles offered in other states come with a higher risk of poisoning, particularly in children, because of deceptive packaging and underestimated potency.

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Indian Tribe Within North Carolina Votes To Legalize Marijuana, Snubbing Anti-Cannabis GOP Congressman

The Eastern Band of Cherokee Indians (EBCI) passed a referendum Thursday in favor of legalizing marijuana, becoming the first jurisdiction within the borders of North Carolina—or any of its surrounding states—to commit to the policy change. But it will be a while before would-be customers can make a purchase.

According to unofficial results posted by the EBCI’s Board of Elections, members approved the measure by a margin of 70 percent to 30 percent. Although the referendum does not legalize cannabis automatically, tribal leaders have said they’ll follow voters’ lead when they ultimately take up the issue.

The referendum asked the tribe’s enrolled members, “Do you support legalizing the possession and use of cannabis for persons who are at least twenty-one (21) years old, and require the EBCI Tribal Council to develop legislation to regulate the market?”

Sales would be open to all adults over 21, regardless of tribal membership.

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