Tag: psychedelics

RFK Jr. and other Trump admin officials back psychedelics for mental health relief

For decades, advocates of psychedelic substances have brought a bold message to Washington, D.C., that currently illicit, mind-altering drugs, such as LSD and MDMA, should warrant approval for therapeutic use in treating severe depression, PTSD, and other treatment-resistant conditions.

Borderline Personality Disorder (BPD) and clinical depression are distinct conditions, even though they often share overlapping symptoms like persistent sadness, hopelessness, and suicidal ideation. However, the underlying causes and mechanisms differ, which is why antidepressants tend to be less effective (or non-effective) for BPD-related emotional distress. Antidepressants target mood-related neurochemistry, not the deep-seated behavioral, relational, and emotional regulation issues seen in BPD.

In addition to the conditions mentioned above, a wide range of other mental disorders, including Post-Traumatic Stress Disorder (PTSD), have also been shown to respond less effectively to pharmaceutical treatments as well.

But now, for the first time, a presidential administration appears poised to give them a try — in the name of mental health.

Trump officials (and nominees) that have expressed an interest in utilizing psychedelics for mental health issues:

  • Robert F. Kennedy Jr. – Secretary of Health and Human Services
  • Doug Collins – Secretary of Veterans Affairs
  • Dr. Casey Means – Trump Nominee for U.S. Surgeon General
  • Marty Makary – FDA Commissioner

“This line of therapeutics has tremendous advantage if given in a clinical setting and we are working very hard to make sure that happens within 12 months,” Kennedy Jr. (RFK Jr.) told members of Congress.

The announcement coincides with a growing embrace of psychedelics in traditionally conservative strongholds like Texas, where former Trump cabinet member and former Texas Governor Rick Perry has emerged as a vocal advocate.

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Psychedelic Retreats ‘Significantly Improved’ Mental Health For Military Veterans With PTSD And Depression, Study Finds

A new study of military veterans who attended psychedelics retreats finds that psilocybin and ayahuasca both yielded significant improvements in participants’ mental health, including reductions in symptoms of PTSD, depression and anxiety as well as improved sleep, quality of life and post-deployment reintegration.

The report, published in the journal Brain and Behavior, describes the research as “the first study to investigate psychedelic retreats as a holistic therapy for veterans’ mental health alongside community reintegration.”

“Psilocybin and ayahuasca retreats significantly improved veterans’ mental well-being, quality of life, PTSD, anxiety, depression, sleep, concussion, and post-deployment reintegration,” it says, adding that the retreats “could provide a treatment framework to aid veterans’ recovery by addressing psychological well-being, communal factors, and reintegration into civilian life.”

The study followed 55 veterans who self-enrolled in psychedelic retreats using psilocybin or ayahuasca following a program by Heroic Hearts Project, a nonprofit that connects veterans with psychedelic therapy in jurisdictions where it’s legal.

“For psilocybin, the substance was taken as a tea brewed from dried psilocybin mushrooms with individualized doses determined by the retreat staff between 1.5 and 3.5 g for Session 1 and between 3 and 5 g for Session 2,” the report says. “One gram boosters of psilocybin were offered one hour from the initial dose.”

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Psychedelic Drug May Slow Aging

Could magic mushrooms hold the key to slowing down aging? New research from Georgia’s Emory University suggests they just might.

A new study has found that psilocin—a compound produced in the body after consuming psilocybin, the active ingredient in psychedelic mushrooms—extended the lifespan of human skin and lung cells in the lab by more than 50 percent.

The researchers also found that mice treated with psilocybin lived 30 percent longer—not to mention more healthily—than their peers.

“This study provides strong preclinical evidence that psilocybin may contribute to healthier aging—not just a longer lifespan, but a better quality of life in later years,” Dr. Ali John Zarrabi, Director of Psychedelic Research at Emory University’s Department of Psychiatry said in a statement.

“As a palliative care physician-scientist, one of my biggest concerns is prolonging life at the cost of dignity and function. But these mice weren’t just surviving longer—they experienced better aging,” added Zarrabi, who co-led the study.

As part of their study, the researchers ran the first long-term assessment of psilocybin’s systemic effects in living animals.

They treated aged, 19-month-old mice—which is something like 60–65 in human years—with an initially low psilocybin dose of 5 mg, followed by a high dose of 15 mg every month for 10 months.

The team found that psilocybin-treated mice survived around 30 percent longer than their untreated peers. Moreover, the treated mice also looked healthier for it, with better fur quality, fewer white hairs and even hair regrowth.

While psilocybin is usually studied for its mental health benefits, the findings suggest that the compound may also tackle key drivers of aging.

According to the team, the psilocybin treatments reduced oxidative stress, improved the cells’ ability to repair DNA and helped preserve the length of telomeres—the protective caps on chromosomes that guard against damage leading to diseases like cancer, neurodegeneration and heart disease.

“Most cells in the body express serotonin receptors, and this study opens a new frontier for how psilocybin could influence systemic aging processes, particularly when administered later in life,” said senior author and former Emory professor Louise Hecker in a statement.

Though psilocybin may be best known for its hallucinogenic effects on the brain, most cells in the body have serotonin receptors, suggesting it could have much wider impacts.

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Czech Republic Bill To Legalize Marijuana Home Cultivation And Allow Psilocybin For Medical Use Heads To President’s Desk

Lawmakers in the Czech Republic have passed a bill to reform the nation’s drug laws by legalizing simple possession and home cultivation of marijuana and allowing the use of psilocybin for medical purposes.

One month after the Chamber of Deputies approved the legislation, the Senate gave it final approval on Thursday. It now heads to the desk of President Petr Pavel to be signed into law.

The drug policy reforms are part of a package of amendments to the Czechia’s criminal code that supporters say will reduce spending on low-priority offenses, lower the number of people behind bars and reduce recidivism.

“The amendment will help criminal law better distinguish between truly socially harmful behavior and cases that do not belong in criminal proceedings at all,” outgoing Justice Minister Pavel Blažek said last month, according to a translated report from broadcaster Česká Televize (CT).

With respect to cannabis, the proposal would legalize possession of up to 100 grams of marijuana at home or 25 grams in public. Cultivation of up to three plants would also be allowed, though four or five plants would be a misdemeanor and more than that would be a felony. Possession of more than 200 grams would also carry criminal penalties.

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Utah Passed a Religious Freedom Law. Then Cops Went After This Psychedelic Church.

When Bridger Lee Jensen opened a spiritual center in Provo, Utah, he contacted city officials to let them know the religious group he had founded, Singularism, would be conducting ceremonies involving a tea made from psilocybin mushrooms. “Singularism is optimistic that through partnership and dialogue, it can foster an environment that respects diversity and upholds individual rights,” Jensen wrote in a September 2023 letter to the Provo City Council and Mayor Michelle Kaufusi. Seeking to “establish an open line of communication” with local officials, Jensen invited them to ask questions and visit the center.

Jensen’s optimism proved to be unfounded. The city did not respond to his overture until more than a year later, when Provo police searched the Singularism center and seized the group’s sacrament: about 450 grams of psilocybin mushrooms from Oregon. The seizure resulted from an investigation in which an undercover officer posed as a would-be Singularism facilitator.

That raid happened in November 2024, less than eight months after Utah Gov. Spencer Cox, a Republican, had signed the state’s version of the federal Religious Freedom Restoration Act (RFRA). The state law likely protects Singularism’s psychedelic rituals, a federal judge ruled in February. U.S. District Judge Jill Parrish granted Jensen’s request for a preliminary injunction against city and county officials, ordering them to return the mushrooms and refrain from further interference with the group’s “sincere religious use of psilocybin” while the case is pending.

“In this litigation, the religious-exercise claims of a minority entheogenic religion put the State of Utah’s commitment to religious freedom to the test,” Parrish wrote in Jensen v. Utah County. If such a commitment “is to mean anything,” she said, it must protect “unpopular or unfamiliar religious groups” as well as “popular or familiar ones.”

Parrish noted that “the very founding of the State of Utah reflects the lived experience of that truth by members of the Church of Jesus Christ of Latter-day Saints.” In light of that history, she suggested, “it is ironic” that “not long after enacting its RFRA to provide special protections for religious exercise, the State of Utah should so vigorously deploy its resources, particularly the coercive power of its criminal-justice system, to harass and shut down a new religion it finds offensive practically without any evidence that [the] religion’s practices have imposed any harms on its own practitioners or anyone else.”

Under the federal RFRA, which Congress enacted in 1993, the government may not “substantially burden a person’s exercise of religion” unless it shows that the burden is “the least restrictive means” of furthering a “compelling governmental interest.” In 2006, the Supreme Court unanimously ruled that RFRA protected the American branch of a syncretic Brazil-based church from federal interference with its rituals, even though the group’s sacramental tea, ayahuasca, contained the otherwise illegal psychedelic drug dimethyltryptamine.

The Supreme Court has said RFRA cannot be applied to state and local governments. Laws like Utah’s, which 29 states have enacted, aim to fill that gap.

The defendants in Jensen’s case—Utah County Attorney Jeffrey Gray, the county, and the city of Provo—argued that Utah’s RFRA did not apply to Singularism, which they portrayed as a drug trafficking operation disguised as a religion. Parrish rejected that characterization. “Based on all the evidence in the record,” she wrote, “the court has no difficulty concluding that Plaintiffs are sincere in their beliefs and that those beliefs are religious in nature.”

Parrish also concluded that “preventing Singularism’s adherents from pursuing their spiritual voyages” imposed a substantial burden on their religious freedom that was not “the least restrictive means” of addressing the government’s public safety concerns. She noted that Utah allows religious use of peyote and has authorized “behavioral health treatment programs” in which patients can receive psilocybin.

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DEA Judge Sides With Agency On Proposal To Ban Two Psychedelics Despite Challenge From Scientific Researchers

A Drug Enforcement Administration judge has formally sided with the agency in its attempt to ban two psychedelic compounds that researchers say hold significant therapeutic potential, recommending that they be placed in Schedule I of the Controlled Substances Act (CSA).

In a ruling on Friday, DEA Administrative Law Judge (ALJ) Paul Soeffing said he advised the agency to move forward with its plan to place the psychedelics—2,5-dimethoxy-4-iodoamphetamine (DOI) and 2,5-dimethoxy-4-chloroamphetamine (DOC)—in Schedule I.

This follows administrative hearings where researchers and advocates, including Panacea Plant Sciences (PPS) and Students for Sensible Drug Policy (SSDP), have fought against DEA to ensure that the psychedelics can continue to be utilized in research.

But in the 118-page ruling, Soeffing ultimately said that “the record contains substantial evidence regarding the eight factors required for consideration under 21 U.S.C. § 811(c) to support recommending the scheduling of DOI and DOC,” referring to an administrative standard for determining the health risks and benefits of substances before when placing them in the CSA.

“Furthermore, I find that the record contains substantial evidence regarding the three factors required for consideration under 21 U.S.C. § 812(b)(1) to support recommending the placement of DOI and DOC in Schedule I,” he said, adding that the fact that the United Nations put DOC specifically on its own controlled substances list justifies its prohibition.

The bulk of the recommendation, which must be approved by the DEA administrator before potentially being codified, recounts the competing arguments between DEA and organizations opposing the scheduling action. But this ruling could reignite an ongoing legal challenge that PPS levied against the agency, challenging the fundamental constitutionality of the ALJ proceedings in drug scheduling rulemaking.

“It’s not a surprise that a DEA employee would side with the DEA,” PPS CEO David Heldreth told Marijuana Moment on Friday. “We find that the supposed impartiality of the judge is highly questionable due to that, and we plan to appeal this ruling and continue our lawsuit against the DEA.”

SSDP was among stakeholders who requested the psychedelics hearing in the first place, in hopes of challenging what they view as a lack of evidence justifying DEA’s proposed ban. Researchers have pointed out that DOI and DOC, as currently unscheduled substances, have been key components in psychedelics research that show potential in the treatment of anxiety and depression, for example.

Researchers have also argued that DEA has failed to meet the statutory burden of demonstrating that either psychedelic compound has high abuse potential. There are no documented cases in medical literature of “distressing responses or death” related to human consumption of DOI, nor has there been any established evidence of a high risk of dependence, SSDP said in a pre-hearing filing in July.

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High Doses Of LSD Lead To ‘Greater Reductions In Depression’ Compared To Low Doses Of The Psychedelic, New Study Finds

Taking a high dose of LSD, coupled with assisted therapy, led to “greater reductions in depression” among patients compared to those who received a low dose of the psychedelic, according to a new study.

Researchers at the University of Basel in Switzerland investigated the therapeutic potential of LSD for people with moderate-to-severe major depressive disorder, and they found the substance showed “promise” as a “novel approach” to treating the condition.

Notably, the study—published this month in the journal Med—indicated that “high-dose-LSD-assisted therapy reduced depressive symptoms more than low-dose therapy” and that the improvements lasted for up to 12 weeks after the treatment.

The randomized, double-blind trial involved administering doses of 100μg and 200μg of LSD for one cohort and two doses of 25μg of the psychedelic for the other. Symptoms of depression were measured at multiple intervals, starting with the baseline and followed up with examinations after two weeks, six weeks and 12 weeks.

After assessing the 61 patients post-administration, the researchers concluded that the “findings of this exploratory study support further investigation of LSD-assisted therapy in depression in a larger phase 3 trial.”

“The present trial’s strengths include a clinically representative sample with respect to the duration of illness, common comorbid conditions, and various pretreatments,” the study authors said. “Other strengths include the comparison with a low-dose group and a relatively long follow-up period of 12 weeks after the last administration.”

“LSD could be used safely within the framework of this study,” they said, adding that compared to previous trials involving psilocybin, “LSD has a longer duration of action.”

“This prolonged effect makes clinical application more resource intensive. It remains to be resolved whether this extended duration offers clinical advantages,” the study text says. “Furthermore, it is yet to be determined if there are other relevant differences among hallucinogenic drugs in terms of therapeutic potential.”

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Why Is Texas Supporting Psychedelics Research While Criminalizing Cannabis?

Texas just announced it will invest $50 million into studying ibogaine, a powerful psychedelic drug that remains illegal at the federal level. The goal? To develop it into a potential Food and Drug Administration-approved treatment for conditions like opioid use disorder, PTSD and depression; especially among veterans.

On the surface, this might sound like a bold and progressive move. But here’s the irony: at the very same time, Texas continues to criminalize cannabis and might soon even outlaw hemp-derived THC products.

Let’s break this down. Cannabis, a plant with centuries of use, decades of medical data and broad public support remains illegal for adult use in Texas. Despite overwhelming national support for legalization—a staggering 88 percent of Americans now back medical or recreational cannabis use)—the state has chosen to double down on prohibition, with lawmakers sending Gov. Greg Abbott (R) a bill that would outlaw consumable hemp products with any traces of THC. He has until Sunday to decide whether to allow that ban to take effect.

Even worse, prohibition isn’t stopping anything. The black market is thriving in Texas. Cartels and illicit operators flood the state with unregulated, untested cannabis. No taxes are collected, no consumer protections exist and legal hemp retailers are now being threatened. It is a misguided public safety argument deluded by a lack of facts and science, political conservatism, contradictory business objectives and outdated stigmas.

Meanwhile, ibogaine, a hallucinogenic alkaloid that can induce intense psychedelic experiences, is now the subject of a $50 million state-funded research push. The same lawmakers who claim cannabis is too dangerous and not well studied are throwing their support behind a compound with far less research and much more uncertainty with the intent of studying it.

This isn’t a critique of psychedelic medicine. Ibogaine may very well hold incredible therapeutic value. But if Texas is willing to support cutting-edge, controversial treatments for serious mental health and addiction issues, why not start with widely available data and access to cannabis? Cannabis has already been shown to help with chronic pain, anxiety, sleep, seizures and opioid dependency.

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Colorado Governor Grants Mass Psilocybin Pardon Following Voters’ Approval Of Psychedelics Legalization At The Ballot

The governor of Colorado has announced a first-ever round of mass pardons for people with psilocybin-related convictions.

Just about two weeks after Gov. Jared Polis (D) signed a bill into law empowering him and future governors to issue clemency for people who’ve committed psychedelics offenses, he announced during a speech at the Psychedelic Science 2025 conference on Wednesday that he’s exercising that authority.

The pardons he’s granting through executive order will provide relief to anyone with a state-level conviction for psilocybin and psilocyn possession.

Shortly after signing the legislation that now allows him to grant the pardons, Polis said the reform represents another step “towards a fairer future.” He’s advocated for the policy change since the state legalized certain entheogenic substances in 2022.

“Governor Polis is showing exactly the kind of courage and compassion that we hope to see from all governors across the country by using his executive authority to right the wrongs of prohibition and calling on Colorado municipalities to do the same,” Jason Ortiz, director of strategic initiatives for the Last Prisoner Project (LPP) told Marijuana Moment.

“I look forward to working with his office to support and empower local municipalities to carry the torch of freedom forward until there is no one burdened by a criminal history for actions that are now generating tax revenue across the state of Colorado,” he said.

The psychedelics clemency move comes several years after Polis issued mass pardons for people with prior marijuana convictions.

The recently enacted psychedelics legislation from Sen. Matt Ball (D) and Rep. Lisa Feret (D) authorizes governors to grant clemency to people with convictions for low-level possession of substances such as psilocybin, ibogaine and DMT that have since been legalized.

It will also require the Colorado Department of Public Health and Environment (CDPHE), Department of Revenue (DOR) and Department of Regulatory Agencies (DORA) to “collect information and data related to the use of natural medicine and natural medicine products.”

That must include data on law enforcement activities, adverse health events, consumer protection claims and behavioral impacts related to psychedelics.

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Colorado Healing Center Facilitates First Psilocybin Session Under Voter-Approved Psychedelics Legalization Law

For the first time, a Colorado patient has taken a legal supervised dose of psilocybin under the state’s natural medicine program. That’s according to the The Center Origin, which in April became the state’s first licensed healing center as part of a buildout of the voter-approved system that was completed last month.

“Big news,” the facility’s CEO and founder, Elizabeth Cooke, said on social media on Sunday. “Last week, we held our very first psilocybin session for psychedelic-assisted healing.”

“A milestone moment is here and a new chapter in healing has begun!” she wrote. “This marks the beginning of our work offering safe, intentional, and transformative psychedelic-assisted healing experiences to those seeking deeper growth and restoration.”

Colorado regulators last month certified the first testing laboratory for the natural medicine program, putting the final piece of the state’s psychedelic infrastructure in place.

Following that step, Gov. Jared Polis (D) announced that the second-in-the-nation state psychedelics program was “fully launched for operations.”

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