Tag: ebola

Chinese scientists create 90% lethal Ebola-like virus to study eye disorders

Chinese scientists have genetically modified a virus that imitates Ebola infection. This virus has caused severe eye ulcers and ultimately wiped out an entire group of hamsters.

Researchers are hopeful that this study will aid in the research of Ebola-related eye disorders.

In this study, vesicular stomatitis, typically found in livestock, was harboring the Ebola virus. When they gave it to the hamsters, the entire group died after the ulcers in their eyes worsened.

New model reveals promising insights into Ebola virus research

Vesicular stomatitis (VSV), carries a part of the Ebola virus called glycoprotein (GP). It helps the virus to enter and infect the cells. Five female and five male hamsters that were up to three weeks old died within three days.

They showed symptoms similar to those in Ebola patients, such as weight loss, multi-organ failure, severe eye inflammation, and ulcers. Additionally, the hamsters had high levels of the virus in their bodies.

Scientists are optimistic that this new model could help in future research on Ebola-related eye disorders. “All animals died within 2-3 days after infection,” the researchers observed, noting that this model could be useful for testing Ebola vaccines.

According to the scientists, this model allowed for quick preclinical testing of Ebola virus countermeasures in BSL-2 conditions.

They added, “This surrogate model is a safe, effective, and cost-efficient tool for rapid preclinical evaluation of medical countermeasures against the Ebola virus under BSL-2 conditions. It has the potential to accelerate technological advances and breakthroughs in combating Ebola virus disease.”

More accessible to researchers for studying

The Ebola virus causes internal bleeding and tissue damage and is spread by direct contact with infected body fluids, such as blood or sweat, or by touching contaminated objects. This is significant because studying Ebola requires expensive and high-level biological security, like that in BSL-4 facilities.

As a result, the virus has been less accessible to scientists. According to the scientists, the development of countermeasures against EBOV has been hindered by the lack of ideal animal models. The reason was that EBOV requires handling in BSL-4 facilities.

In the study, they also analyzed the influence of the virus. They found that the virus had accumulated in critical tissues. Like for example the heart, lungs, liver, spleen, kidneys, intestines, and brain. As the study showed, the highest viral loads were found in the liver, and the lowest levels were found in the brain.

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Syrian Hamsters Dead After Chinese Scientists Engineer Horrific Ebola-Enhanced Virus

A group of Chinese scientists have engineered a new virus in which they took a common animal disease (vesicular stomatitis virus, or VSV) and added parts of Ebola in order to mimic Ebola symptoms in a lab setting using animals.

The result? A group of Syrian hamsters that received the lethal injection “developed severe systemic diseases similar to those observed in human Ebola patients, including multi-organ failure, the Daily Mail reports, citing the team’s study.

The team studied five female and five male hamsters that were three weeks old – all but two of which died between two and three days. The females – all of which died, showed decreased rectal temperature and up to 18% weight loss, the males lost 15% of their weight and died – except two, which survived and gained 20% more weight than they started with.

Some of the infected hamsters developed disgusting secretions in their eyes, which impaired vision and resulted in scabs on the surface of their eyeballs.

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