Tag: dna

Unmasking the Contamination Crisis in mRNA Injectable Drugs: A Public Health Catastrophe in the Making

The alarm bells began to ring loudly when Kevin McKernan first uncovered alarmingly high levels of DNA contamination in early 2023, a finding that has since been corroborated by numerous independent scientists. The most recent revelation comes from a study conducted in a laboratory utilized by the FDA itself, exposing staggering levels of contamination in every analyzed vaccine lot. This discovery, particularly significant because of the FDA’s connection, suggests that the problem may be even worse than initially reported. Methodological limitations raise the possibility that larger, more dangerous DNA fragments capable of disrupting cellular functions remain undetected. Instead of taking responsibility, the FDA—the agency charged with safeguarding public health—has chosen to distance itself from these damning findings. By denying ownership of the study and refusing to act, the FDA has demonstrated a chilling disregard for public safety, prioritizing perception over accountability.

DNA contamination, even in small fragments, is far from a hypothetical risk confined to theoretical science. These fragments can trigger immune pathways like cGAS-STING,[1] leading to chronic inflammation and immune system dysregulation. The threat of genomic integration—where foreign DNA integrates into human cells—looms ominously, with potentially catastrophic consequences if it occurs in critical regions such as oncogenes or tumor suppressor genes. This risk is compounded by the lipid nanoparticles (LNPs) used in vaccine delivery, which protect these fragments and enhance their ability to enter human cells. The very mechanism designed to deliver the mRNA payload efficiently may inadvertently pave the way for these fragments to wreak havoc within the human body.

The FDA laboratory’s report indicated that the DNA contamination consisted of non-replicating fragments, which might appear less dangerous at first glance. The probability of genomic integration was estimated at approximately 1 in 10 million cells. While this figure may sound reassuringly small, the broader context reveals a much more alarming reality. The human body contains roughly 37 trillion cells, meaning that even such a low probability translates to an average of around 3,700 cells per individual potentially experiencing genomic integration. If foreign DNA integrates into critical genomic regions in just one of these cells,[2] the results could be catastrophic, leading to mutations that may escape immune detection and cause severe health outcomes over time.

When scaled to the billions of vaccinated individuals worldwide, the potential for population-wide health impacts becomes staggering. The sheer number of affected cells across global populations magnifies the risk of rare but severe reactions, challenging the dismissive assurances of safety provided by regulatory bodies. These are not merely theoretical risks; they are statistically plausible outcomes that demand immediate scrutiny and decisive action. The scale and scope of these potential outcomes should compel regulatory agencies and manufacturers to halt vaccine distribution until these dangers are fully understood and mitigated.

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FDA’s Own Study Finds DNA Contamination in Pfizer Vaccines

A peer-reviewed study performed at a U.S. Food and Drug Administration (FDA) laboratory by high school students has confirmed the presence of a high level of DNA contamination in Pfizer’s mRNA COVID-19 vaccine.

The study, published Dec. 29, 2024, in the Journal of High School Science, was authored by three students at Centreville High School in Clifton, Virginia, and performed under the supervision of FDA scientists.

Maryanne Demasi, Ph.D., an investigative medical reporter, was the first to report on the study.

The research, performed at the FDA’s White Oak Campus in Maryland, found that levels of residual DNA in the Pfizer COVID-19 vaccine were 6 to 470 times higher than regulatory safety limits. The students tested two lots of the vaccine, finding they contained “residual DNA to a level that exceeds 10 ng [nanograms] per dose.”

“The potential health risk posed by residual small DNA fragments is currently unknown,” the study stated. However, the authors also said that DNA contamination may result in insertional mutagenesis — or DNA mutations — that can cause cancer.

Speaking last month on “The Defender In-Depth,” Kevin McKernan, who first identified DNA contamination in the shots in 2023, said DNA in vaccines can pose health risks because the DNA “could integrate into the genome and cause disruption of the genome … or it could disrupt other genes that are related to cancer.”

The FDA did not respond to multiple requests for comment on the study.

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New Zealand media’s go-to source for expert opinions supports a bill to deregulate the use of genetic modification; Dr. Guy Hatchard responds

Guy Hatchard, PhD, was formerly Director of Natural Products at Genetic ID (now FoodChain ID) a global food safety testing and certification company. He presented to the original Royal Commission on Genetic Modification in New Zealand in 2000 which helped to clarify the safety ground rules and labelling requirements for genetically modified organisms (“GMOs”) which currently form a part of the New Zealand Hazardous Substances and New Organisms (“HSNO”) legislation. Dr. Hatchard is retired and has no financial interest in the outcomes of the current legislative initiative to deregulate biotechnology experimentation.

The following is his formal response to the Science Media Centre (“SMC”) – an “independent” source of information for the media on all issues related to research, science and innovation – which has published expert opinions in support of the Bill.

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DNA Contamination In Pfizer COVID Vaccines Up To Four Times Legal Limits, Study Finds

Researchers found DNA in Pfizer’s COVID-19 vaccines at levels three-to-four times higher than regulatory limits, according to a new “bombshell” study.

“This far exceeds the maximal acceptable concentration of 10 ng [nanograms] per clinical dose that has been set by international regulatory authorities,” the authors wrote.

The peer-reviewed study, published this week in the journal Science, Public Health Policy and the Law, also found simian virus 40 (SV40) DNA contaminants in the vaccines. And the researchers determined that the spike proteins produced by the vaccines persist in the body longer than claimed.

The findings led the authors to call for “an immediate halt of all RNA biologicals.”

Karl Jablonowski, Ph.D., senior research scientist at Children’s Health Defense (CHD), told The Defender that DNA contamination may contribute to the increase in autoimmune diseases among the vaccinated. “The immune system operates on very sensitive detections to initiate responses,” he said.

“DNA suddenly deposited into your bloodstream could kickstart the interferon response,” Jablonowski said. “The interferon response, when there’s nothing to find but ‘self,’ could be the springboard for autoimmune disease.”

The study also showed that the spike proteins produced after vaccination persist in the body for at least seven days following vaccination instead of the shorter period Pfizer-BioNTech previously claimed. The spike proteins are also prone to shedding.

These results “raise grave concerns” about mRNA vaccines, the study concluded.

Kevin McKernan, founder of Medicinal Genomics, is the first scientist who identified the presence of SV40 in the mRNA vaccines. He called the new study “a tour de force on the DNA contamination topic.” McKernan wrote about the study on Substack, and said in an X post that the study’s authors “knocked it out of the park.”

Immunologist and biochemist Jessica Rose, Ph.D., agreed. “This paper is the paper of the century. The paper is not only a work of art in terms of the study layout. It is very well-written and settles ongoing ‘issues’ pertaining to allegations made by regulatory bodies that the DNA contamination issue is misinformation,” Rose said.

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BioNTech RNA-Based COVID-19 Injections Contain Large Amounts Of Residual DNA Including An SV40 Promoter/Enhancer Sequence

Background: BNT162b2 RNA-based COVID-19 injections are specified to transfect human cells to efficiently produce spike proteins for an immune response.

Methods: We analyzed four German BNT162b2 lots applying HEK293 cell culture, immunohistochemistry, ELISA, PCR, and mass spectrometry.

Results: We demonstrate successful transfection of nucleoside-modified mRNA (modRNA) biologicals into HEK293 cells and show robust levels of spike proteins over several days of cell culture. Secretion into cell supernatants occurred predominantly via extracellular vesicles enriched for exosome markers. We further analyzed RNA and DNA contents of these vials and identified large amounts of DNA after RNase A digestion in all lots with concentrations ranging from 32.7 ng to 43.4 ng per clinical dose. This far exceeds the maximal acceptable concentration of 10 ng per clinical dose that has been set by international regulatory authorities. Gene analyses with selected PCR primer pairs proved that residual DNA represents not only fragments of the DNA matrices coding for the spike gene, but of all genes from the plasmid including the SV40 promoter/enhancer and the antibiotic resistance gene.

Conclusion: Our results raise grave concerns regarding the safety of the BNT162b2 vaccine and call for an immediate halt of all RNA biologicals unless these concerns can be dispelled.

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Scientists Are Developing CRISPR Gene-editing Tools to Cure Inherited Diseases — But There’s a Catch

CRISPR-based gene-editing tools are being developed to correct specific defective sections of the genome to cure inherited genetic diseases, with some applications already in clinical trials.

However, there is a catch: under certain conditions, the repair can lead to large-scale deletions and rearrangements of DNA — as in the case of targeting the NCF1 gene in chronic granulomatous disease (CGD). This was reported by a team of researchers and physicians from the ImmuGene clinical research program at the University of Zurich.

Their findings have important implications not just for gene editing-based therapy, but also for CRISPR-mediated gene editing of animals and plants, where the same types of large-scale genetic damage could be triggered.

Indeed, because such editing is carried out with much less caution in non-human organisms, the likelihood of such large-scale damage occurring is hugely increased (see below on multiplexing).

The study also shows that attempts to avoid these problems by using adaptations of CRISPR gene editing technologies, such as prime and base editing, may not succeed.

This research on CGD is also only the latest in a series of studies that have repeatedly shown that different types of unintended mutations resulting from gene editing can affect the functioning of multiple gene systems, with potentially damaging consequences.

What is CGD?

CGD is a rare hereditary disease that affects about one in 120,000 people. The disease impairs the component of the immune system responsible for fighting off infections, which can be life-threatening to the patient.

One variant of CGD is caused by the absence of two letters in the DNA base unit gene sequence which codes for the NCF1 protein. This error results in the inability of blood cells known as neutrophils to produce an enzyme complex that plays an essential role in the immune defense against bacterial, yeast, and fungal infections.

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Operation Warp Speed official questions COVID vaccine purity, worries ‘they may ingrate’ into DNA

COVID-19 vaccine supporters are fond of sneering at public figures who have called for the Food and Drug Administration to pull or at least re-evaluate the safety of the increasingly unpopular therapeutics, such as Health and Human Services secretary nominee Robert F. Kennedy Jr., cardiologist Peter McCullough and Florida Surgeon General Joseph Ladapo.

They might have a harder time caricaturing a former Centers for Disease Control and Prevention director who ran the agency when COVID vaccines were being developed, promoted vaccination and repeat boosting as recently as 2022 and promoted cloth face masks as “one of the most powerful weapons we have” against COVID, before vaccines were available.

Robert Redfield cited “concerns that the mRNA vaccines actually have contaminating nucleic acid in them” but also sequences from Simian Virus 40, “which is a tumor virus,” in the debut episode of songwriter, author and Lyme Disease activist Dana Parish’s podcast.

Some of the 98 million polio vaccines given from 1955 to 1963 contained SV 40, which is part of the same family as the human papillomavirus associated with cervical cancer, according to the federally convened Immunization Safety Review Committee’s 2002 review of the evidence for the contamination’s effect on cancer rates.

The review was inconclusive on whether “SV40-contaminated polio vaccine did or did not cause cancer in the vaccine recipients” but affirmed that exposure concerns are “significant because of the seriousness of cancers as the possible adverse health outcomes and because of the continuing need to ensure and protect public trust in the nation’s immunization program.”

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Bacterial DNA a major worry in Jabs

We know about the species of Bacteria used in filthy toxic soups in the production mRNA Jabs, but it appears some people are confused about the extremely high risk of Bacterial DNA contamination in the vile vials and how that varies Lot to Lot.2

Imagine you are swimming inside a vat when they add Sodium Hydroxide to make the live bacteria spill their guts to yield the desired circular Plasmid double stranded DNA. You need to think of the Bacterial DNA which is rolled up into a tight little Nucleoid ball creating delight for topologists plus all the other toxins liberated.3

How effective is the filtration? We know Bacterial DNA is “nicked” by the alkali and even mechanical handling. What tests have been done by Regulatory Authorities.

Have all test results been redacted?

How much Bacterial DNA has been found by indepedent labs?

When BioNTech applied for Emergency Use Authorization in 2020, the scientists assessing the Process 2 Poojabs5 were clearly aware of the risk from Bacterial Host Cell Genomic DNA “impurities”.

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FDA Brushed Off Concerns About DNA Fragments in Gardasil’s HPV Vaccine

Over the last two years, cancer genomic experts have raised concerns about the presence of residual DNA fragments in the mRNA COVID-19 vaccines, saying that it has the potential to increase the risk of developing cancer.

This mirrors the concerns raised several years ago about the safety of the Gardasil human papillomavirus (HPV) vaccine, manufactured by Merck & Co.

In 2011, Sin Hang Lee, a pathologist and 30-year veteran in DNA analysis, made the startling discovery of synthetic DNA fragments in several vials.

“I was shocked to find DNA fragments in the HPV vaccine because DNA is not supposed to be there,” Lee recalls.

“They use DNA to make the vaccine, but then it is supposed to be chopped up and removed in the manufacturing process,” he said.

Lee, an internationally recognized expert in molecular gene detection, carefully documented his findings in a report that was sent to the U.S. Food and Drug Administration (FDA) for review.

The FDA investigated.

On Sept. 23, 2011, the FDA’s Center for Biological Evaluation and Research (CEBR) responded by saying it had evaluated the concerns in Lee’s report, and determined that the Gardasil vaccine was “safe and effective.”

The FDA did acknowledge that Lee found residual DNA in the vaccine, but said it was “expected” and “inevitable” in products that are manufactured using recombinant technology.

The agency also said it remained confident that the residual DNA was “not a risk to vaccine recipients.”

“The presence of residual DNA is not a safety factor as defined by US regulations, and is not required to be included in Gardasil’s labeling,” wrote the FDA.

The following month (Oct. 21, 2011) the FDA quietly updated its website to reflect the presence of DNA fragments in the vaccine, assuring the public there was “no safety risk.”

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Hardy, Radiation-Resistant Organism Could Rewrite Your Genetic Code to Cure High Cholesterol

Scientists are programming one of the world’s hardiest, most radiation-resistant organisms to rewrite a specific gene, allowing them to cure a common type of inherited high cholesterol. Dubbed TnpB and originating from the bacterium Deinococcus radiodurans, this exceptionally robust microbe also survives cold, dehydration, vacuum, and acid, making it an ideal tool for genetic editing.

Although the team has only tested its “genetic scissors” on mice models with an inherited predisposition to a type of high cholesterol called hypercholesterolemia, which currently affects 31 million Americans, the researchers believe their approach will one day allow them to cure high cholesterol in humans by essentially rewiring their genetic code.

Reprogramming TnpB to Cure High Cholesterol

In the published study outlining the new genetic reprogramming approach, the researchers note that genetic editing has shown significant promise in editing certain inherited health conditions by essentially “reprogramming” specialized bacteria to genetically edit the faulty gene in a person’s genetic code with a properly functioning one. However, the process, made famous by the CRISPR gene editing tool, has resulted in mixed successes.

One of the primary limiting factors of the CRISPR-Cas organism most commonly used in genetic editing is its size. According to the study authors, the microbe is too large to be precisely targeted, which “creates challenges when trying to deliver them to the right cells in the body.”

More recently, researchers in genetic editing have begun to focus on the organism’s “evolutionary progenitors,” some of which are much smaller than the CRISPR-Cas microbe. Among the most promising is TnpB, whose smaller size and hardiness offer scientists a new path for genetic editing.

These smaller progenitors are less efficient at reprogramming and show limited targeting ability due to their limited recognition requirements when binding DNA than the larger CRISPR-Cas microbes. Now, the researchers behind this study say they may have finally overcome that limitation, resulting in a much more efficient method of targeting TnpB to cure high cholesterol.

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