Tag: cannabis

Cannabis compounds could reverse disease affecting one-third of adults

Compounds found in cannabis could provide a new roadmap for treating the world’s most common chronic liver disorder, according to a study released by the Hebrew University of Jerusalem.

The research, published in the British Journal of Pharmacology, found that cannabidiol (CBD) and cannabigerol (CBG) significantly reduced liver fat and improved metabolic health in experimental models.

CBD is the more widely studied non-intoxicating cannabinoid, while CBG is a less common “precursor” cannabinoid from which CBD is formed.

Unlike THC, the primary psychoactive component in cannabis, these compounds do not produce a “high,” making them viable candidates for long-term medical treatment, the study suggests.

Metabolic dysfunction-associated steatotic liver disease (MASLD) currently affects approximately one-third of the global adult population, according to health data.

The condition, which is closely linked to obesity and insulin resistance, has few approved pharmaceutical treatments, the researchers said, leaving patients to rely largely on lifestyle changes that can be difficult to maintain. 

“Our findings identify a new mechanism by which CBD and CBG enhance hepatic energy and lysosomal function,” said lead study author Joseph Tam, director of the Multidisciplinary Center for Cannabinoid Research at Hebrew University, in a press release.

The study highlights a process called “metabolic remodeling,” in which the cannabis compounds created a “backup battery” for the liver by increasing levels of phosphocreatine, a high-energy molecule stored in muscle cells.

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GOP Congressman Running For Florida Governor Admits To Selling Marijuana Despite Opposing Legalization And Sentencing Reform

A GOP congressman running for governor in Florida who has opposed marijuana legalization in the state and sponsored federal legislation to upend a Washington, D.C. sentencing reform law has admitted for the first time that he was arrested for selling cannabis as a young adult.

Rep. Byron Donalds (R-FL), a Trump-endorsed GOP candidate vying to replace Florida Gov. Ron DeSantis (R), was pressed on the apparent disconnect during an interview with CBS Miami that aired on Saturday.

While it was previously known that Donalds faced an arrest over marijuana in 1997—only to have the charges dropped years later as part of a pre-trial diversion program—this marked the first time he’s publicly admitted to selling small amounts of cannabis and acknowledged that he benefitted from the type of criminal justice reform law he’s worked to undermine in the District of Columbia.

“Honestly, I was walking down the street, I was leaving a party, officers came up, asked me if I would empty my pockets. I said, ‘Yes, of course.’ I had a dime bag of marijuana in my pocket. That’s the story,” the congressman said. “It was bad decisions. I can’t undo that decision.”

Donalds said he sold “low-level amounts” of marijuana, reiterating that he made “terrible decisions” and that it was among the things he did in his early adulthood that he wishes he could “undo.”

“I wish I could undo [it]. I wish I could, but I can’t do that,” he said. “I would tell people, if you examine my life since 20 years old, my life has really been a story of redemption.”

But that redemption arc was made possible, in part, thanks to sentencing policy that afforded Donalds a level of relief that he’s sought to deprive D.C. residents of—a point that Rep. Jasmine Crockett (D-TX) raised during a House floor debate last year where she slammed her GOP colleague over the apparent double standard.

“Imagine standing in front of a judge with your life hanging in balance, and instead of prison you’re given a promise of mercy. Your record is wiped clean, and you’ve got a second chance at life,” Crockett said. “Imagine turning that into a promotion and you go to college and get a job and even become a member of Congress. That’s what redemption looks like.”

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Study: Lifetime Cannabis Use Not Associated With Cognitive Decline or Dementia Risk in Older Adults

Cannabis use by older adults is not associated with either accelerated cognitive decline or greater risk of dementia, according to findings published in the journal BMJ Mental Health.

Investigators affiliated with Yale University and the University of Oxford in the United Kingdom assessed cognitive performance in lifetime cannabis consumers and non-users across various domains — including memory, intelligence, and problem solving. Data was drawn from two large nationally representative cohorts (the UK Biobank and the US Million Veteran Program), consisting of several hundred thousand participants.

Researchers reported that those with a history of cannabis use “demonstrated significantly better cognitive performance,” a finding that is consistent with prior studies. Cannabis use “was not associated with increased risk of dementia” and researchers found “no supporting evidence of a causal link with [longitudinal] cognitive decline in later life.”

The study’s authors concluded: “This study represents one of the largest observational investigations to date examining the relationship between cannabis use, cognitive function and dementia risk in older adults. … Our findings are broadly consistent with prior population-based longitudinal studies that have not observed accelerated age-related cognitive decline associated with cannabis use. … Clinicians can consider that occasional or prior cannabis use may not be a major contributor to cognitive aging in this population.”

Commenting on the findings, NORML’s Deputy Director Paul Armentano said: “These results contradict one of the more prominent and longstanding stereotypes about cannabis and cannabis consumers. It is unfortunate that these stereotypes often go unchallenged in the media and elsewhere. It is even more unfortunate that studies refuting these long-held stereotypes seldom receive the type of mainstream attention they deserve.”

Several other recent studies have reported similar results. For example, an Israeli study of over 67,000 older adults reported that participants with a history of cannabis use “performed better across all cognitive domains: attention, executive function, processing speed, visual and working memory. … Additionally, past use was associated with a slower decline in executive function.”

A Danish study similarly concluded that cannabis consumers experienced “significantly less cognitive decline” over their lifetimes than did non-users.

Most recently, a study published in January in the Journal of Studies on Alcohol and Drugs concluded: “Greater lifetime [cannabis] use was also associated with better performance on cognitive tasks assessing learning, memory, processing speed, and task switching, aligning with growing evidence of potential neuroprotective effects of cannabis in aging populations. … This study adds to a growing body of evidence that cannabis use may be associated with greater brain volume and cognitive performance in aging adults, especially in regions rich in cannabinoid receptors.”

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Cannabis timeline pushed to 20,000+ years

New research suggests cannabis use may date back 20,000 years or more, far earlier than previously thought.

Most scholars agree cultivation of cannabis began in Asia between 10,000 and 12,000 years ago, during the advent of farming following the last ice age. But a 2023 morphometric study of ancient cannabis seeds suggests it may have begun far earlier — 20,000 years ago or more — in what is now Western China and the Tibetan Plateau.

The study looked at the size of seeds, which began to change as people started using them thousands of years ago.

People have been living in the Tibetan Plateau for up to 38,000 years, and in Central Asia for up to 50,000 years, so it is plausible cannabis has been used up to that long.

Cannabis has been around for millions of years, and the oldest plant material discovered so far is seeds dated to 8000 BC, found in Okinoshima, Japan at a neolithic site linked to the Jomon people. The seeds were likely used as food and to make oil.

Pottery found at an ancient archaeological site in Taiwan and dated to the same period, around 8000 BC, has impressions made with hemp cord, meaning cannabis was used widely across Asia by that time.

Along with using it as a source of food, the 2023 study suggests that by 6000 BC, cannabis was being cultivated for its fibre — what we now call hemp. It was around 3000BC that people began selecting cannabis for its trichomes, which contain the medicinal and psychoactive compounds.

Those findings align with a 2021 genomic study that also places domestication around 10000 BC, with a slightly different timeline — hemp selection beginning around 4000 BC, and medicinal/psychoactive use emerging around 3000 BC. Cannabis also appears to have reached the Indian subcontinent from China around that time.

“The first users were probably nomadic peoples,” explains Barney Warf, a professor of geography at the University of Kansas. “We know this from burial mounds of chieftains.”

Warf authored the 2014 paper High Points: An Historical Geography of Cannabis, which traces the spread and use of cannabis from ancient to modern times.

Several nomadic tribes are thought to have been the main conduit for bringing cannabis from Central Asia into India, the Middle East, Northern Africa and Europe between 4000 BC and 2000 BC, says Warf, along routes that would later become known as the Silk Road.

One possible origin for the word ‘Cannabis’ is the Scythian word, ‘Kanab,’ which itself may have come from the Assyrian word ‘Qunubu’. The Scythians were a nomadic group dated to between 900 BC and 200 BC and the Assyrians were in Mesopotamia between 2000 BC and 600 BC.

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Researchers ‘surprised’ by the brain benefits of cannabis usage in adults over 40

Pass the pot to Grandma — her brain might thank you.

A new study is challenging long-held assumptions about cannabis, finding that middle-aged and older adults who use the drug may actually see some brain and cognitive benefits.

The twist comes as cannabis use is climbing among older Americans. Research shows that nearly 1 in 5 people ages 50 to 64 reported using marijuana in the past year, along with 5.9% of those 65 and older.

That’s notable because research on cannabis and the brain has historically zeroed in on adolescents, not aging adults.

“More older adults are using cannabis. It’s more widely available and is being used for different reasons than in younger folks — such as for sleep and chronic pain,” Dr. Anika Guha, a clinical psychologist at the University of Colorado Anschutz Medical Campus and lead author of the study, said in a statement.

“Plus, people are living longer. We have to ask, ‘What are the long-term effects of cannabis use as we continue to age?’”

To dig deeper, Guha and her colleagues analyzed data from 26,362 adults ages 40 to 77, with an average age of 55, all living in the UK.

Participants answered detailed questions about their cannabis use, underwent MRI scans to assess their brain structure and completed a series of cognitive tests.

The researchers zeroed in on brain regions packed with CB1 — a cannabinoid receptor they theorized would be especially affected by cannabis.

One key focus was the hippocampus, which contains a high concentration of these receptors and plays a critical role in memory as we age. It’s also a brain region closely linked to dementia.

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Alabama Lawmakers Pass Bill To Increase Penalties For Smoking Marijuana In A Car Where A Child Is Present

The Alabama House of Representatives Thursday passed a bill that prohibits smoking or vaping marijuana in a car with children.

HB 72, sponsored by Rep. Patrick Sellers, D-Pleasant Grove, would make it a Class A misdemeanor, punishable by up to a year in jail,  for those who smoke marijuana in a car with a child under 19.

The bill passed 77-2 after an unusual debate largely limited to the 29 Democrats in the 105-member chamber over potential unintended consequences. Most Democrats abstained from the vote. Four voted in favor; Reps. Mary Moore, D-Birmingham and TaShina Morris, D-Montgomery, voted against the bill.

“It’s about protecting the children, protecting every single child in the state of Alabama,” Sellers said after the meeting. “And that’s the motivation behind making sure that every child has the 100 percent ability to learn in the best environment that they can and keep them safe.”

Under the bill, individuals who are found to have smoked marijuana in the car with a child would be required to go through an educational program conducted by the Department of Public Health and would be reported by law enforcement to local county human resources departments.

Several Democrats who spoke on the measure cited the toll that harsh drug laws had taken on minority communities.

“It goes back to the heart of criminalization of marijuana in certain communities,” Rep. Juandalynn Givan, D-Birmingham, said after the meeting. “And those are communities that are communities typical of people of color.”

Givan also said House Democrats had wanted to work with Sellers on the bill.

“The Democratic Party, on several attempts, said that this is a bill that we might need to sit down and curate,” she said. “I’m not sure why the sponsor of the bill did not do that.”

Morris raised concerns about the bill’s definition of a child during debate.

“So we’re making a parent responsible for an 18-year-old who has a marijuana smell on them,” she said. “We know at the ages of 16 and 17, especially with the influence of walking outside and going different places, that they are smoking, maybe without the parent even knowing.”

Rep. Rolanda Hollis, D-Birmingham, said during debate that parents don’t know everything that their child does.

“As a parent you may not know, and here I don’t know if the counselor or the principal can call you in to say ‘Hey this is what we smelled on your kid’s jacket, how are we gonna handle this?’ But instead you got me going to a class for something I don’t even know about,” she said.

When asked after the meeting about Morris’ concerns about the bill’s language regarding age, Sellers said parents should “stop making excuses” for their children.

“You know whether or not your child is smoking marijuana. If someone lives in your house, you know they’re smoking marijuana because you can smell it. It’s a distinct smell,” he said.

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Ancient Cannabis Enzymes Reveal How THC and CBD First Evolved

Scientists are taking a deeper look at the origins of cannabis chemistry by reconstructing enzymes from ancient plants, offering new insight into how cannabis first developed the ability to produce compounds like THC and CBD.

In a recent study published in Plant Biotechnology Journal, researchers at Wageningen University & Research rebuilt molecular structures that existed millions of years ago, revealing that ancient forms of cannabis enzymes were more flexible and robust than those found in modern plants.

The team behind the research says they have successfully traced the evolution of cannabinoid chemistry and identified molecular tools that could improve the biotechnological production of modern medicinal cannabinoids.

The Origin of Cannabinoids

In modern cannabis plants, specialized enzymes are responsible for making individual cannabinoids like THC or CBD. Each enzyme is highly efficient at producing one specific compound. The new study shows that this precision is a recent development in cannabis evolution, rather than something that existed from the start.

Early ancestors of cannabis used versatile enzymes that could create several cannabinoids at once. These enzymes became more specialized over time as gene duplication occurred. This led to the distinct chemical profiles seen in cannabis plants today.

The research team provided direct evidence for this evolutionary process by reconstructing ancient cannabis enzymes in the lab. Their results show that the pathways for creating specific cannabinoids like THC appeared relatively recently and became more specialized over time through natural selection.

Rebuilding Lost Enzymes

The team relied on ancestral sequence reconstruction to study this evolutionary history. They compared DNA from modern cannabis and related species to determine what cannabinoid-producing enzymes looked like millions of years ago.

The researchers synthesized the predicted enzymes and tested their functions in the lab. Many of the reconstructed enzymes converted precursor molecules into several different cannabinoids, unlike the more specialized modern enzymes.

These experiments enabled the team to directly test evolutionary hypotheses that had previously relied solely on genetic comparisons.

Ancient Enzymes as Biotech Tools

The most immediate implications of the study are for biotechnology rather than evolutionary biology. When the researchers expressed ancient enzymes in microbial systems, they found that the reconstructed enzymes were often easier to use than those found in modern cannabis plants.

“What once seemed evolutionarily ‘unfinished’ turns out to be highly useful,” said Robin van Velzen, who led the study with colleague Cloé Villard. “These ancestral enzymes are more robust and flexible than their descendants, which makes them very attractive starting points for new applications in biotechnology and pharmaceutical research.”

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Florida Lawmakers Approve Bill To Ban Public Marijuana Smoking Ahead Of Possible Legalization Vote On The Ballot

A Florida Senate panel has advanced legislation to ban smoking or vaping marijuana in public places, a development that comes as an industry-funded campaign is seeking to place a recreational cannabis legalization initiative on the November ballot.

The Senate Regulated Industries Committee on Tuesday approved the bill, which defines a public place as “a place to which the public has access, including, but not limited to, streets; sidewalks; highways; public parks; public beaches; and the common areas, both inside and outside, of schools, hospitals, government buildings, apartment buildings, office buildings, lodging establishments, restaurants, transportation facilities, and retail shops.”

The measure from Sen. Joe Gruters (R), who is also chairman of the Republican National Committee, would specify that marijuana cannot be smoked or vaped in customs smoking rooms at airports.

Sen. Ana Maria Rodriguez (R) presented the bill, SB 986, on Gruters’s behalf at the committee hearing.

“There is currently no prohibition on smoking marijuana in public places if adult use is approved by the voters,” she said, according to Florida Politics. “By banning public smoking of marijuana, we are protecting community health and quality of life, as well as protecting certain outdoor spaces from marijuana smoke such as beaches and parks.”

Rep. Alex Andrade (R) is sponsoring a similar bill to ban public cannabis smoking in the House of Representatives.

The proposals are among a growing list of cannabis legislation that lawmakers are introducing for consideration next year.

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OSU study: Compounds in hemp block COVID-19 from entering human cells

Compounds found in hemp “show the ability to prevent the virus that causes COVID-19 from entering human cells,” Oregon State University says.

New OSU research on hemp and COVID-19 was published Tuesday in the Journal of Natural Products.

Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center in the College of Pharmacy and Linus Pauling Institute, led the study.

According to OSU:

Hemp, known scientifically as Cannabis sativa, is a source of fiber, food and animal feed, and multiple hemp extracts and compounds are added to cosmetics, body lotions, dietary supplements and food, van Breemen said.

Van Breemen and collaborators, including scientists at Oregon Health & Science University, found that a pair of cannabinoid acids bind to the SARS-CoV-2 spike protein, blocking a critical step in the process the virus uses to infect people.

The compounds are cannabigerolic acid, or CBGA, and cannabidiolic acid, CBDA, and the spike protein is the same drug target used in COVID-19 vaccines and antibody therapy. A drug target is any molecule critical to the process a disease follows, meaning its disruption can thwart infection or disease progression.

“These cannabinoid acids are abundant in hemp and in many hemp extracts,” van Breemen said. “They are not controlled substances like THC, the psychoactive ingredient in marijuana, and have a good safety profile in humans. And our research showed the hemp compounds were equally effective against variants of SARS-CoV-2, including variant B.1.1.7, which was first detected in the United Kingdom, and variant B.1.351, first detected in South Africa.”

OSU said those two variants are also known as alpha and beta.

According to OSU:

Characterized by crown-like protrusions on its outer surface, SARS-CoV-2 features RNA strands that encode its four main structural proteins – spike, envelope, membrane and nucleocapsid – as well as 16 nonstructural proteins and several “accessory” proteins, van Breemen said.

“Any part of the infection and replication cycle is a potential target for antiviral intervention, and the connection of the spike protein’s receptor binding domain to the human cell surface receptor ACE2 is a critical step in that cycle,” he said. “That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs.”

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