For the first time in the peer-reviewed literature— we present direct molecular evidence that genetic material from a COVID-19 mRNA “vaccine” has integrated into the human genome.
In our sentinel peer-reviewed case report, Genomic Integration and Molecular Dysregulation in Aggressive Stage IV Bladder Cancer Following COVID-19 mRNA Vaccination—published in the International Journal of Innovative Research in Medical Science (John A. Catanzaro, Nicolas Hulscher, and Peter A. McCullough; a Neo7Bioscience–McCullough Foundation collaboration)—we describe a previously healthy 31-year-old woman who developed rapidly progressive stage IV bladder cancer within 12 months of completing a three-dose Moderna mRNA injection series.
Bladder cancer is exceedingly rare in young women, and such aggressive presentations are almost unheard of.
To investigate, we performed comprehensive multi-omic profiling, including plasma-derived circulating tumor DNA, whole-blood RNA, and urine exosome proteomics. What we uncovered was striking:
- Direct genomic integration event: Within circulating tumor DNA, a host–vector chimeric read mapped to chr19:55,482,637–55,482,674 (GRCh38), in cytoband 19q13.42, positioned ~367 kb downstream of the canonical AAVS1 safe harbor and ~158 kb upstream of ZNF580 at the proximal edge of the zinc-finger (ZNF) gene cluster. This sequence aligned with perfect 20/20 bp identity to a segment (bases 5905–5924) within the Spike open reading frame (ORF) coding region (bases 3674–7480) of the Pfizer BNT162b2 DNA plasmid reference (GenBank accession OR134577.1).
- Oncogenic driver hyperactivation (KRAS, NRAS, MAPK1, ATM, PIK3CA, SF3B1, CHD4) — unleashing uncontrolled proliferative and malignant signaling cascades.
- Critical DNA repair pathway collapse (ATM, MSH2) — leaving the genome acutely vulnerable to instability, double-strand breaks, and catastrophic mutations.
- Severe transcriptomic and proteomic disarray across plasma, blood, and urine biospecimens — consistent with systemic molecular breakdown.
Although the patient received only Moderna injections, the sequence aligned to Pfizer’s published BNT162b2 plasmid reference because Moderna has never deposited its proprietary plasmid in NCBI. Crucially, both Pfizer and Moderna vaccines encode the same prefusion-stabilized SARS-CoV-2 Spike protein and therefore share identical stretches of nucleotide sequence within the Spike ORF coding region. It is within one of these conserved regions that the integration was captured, producing the perfect 20/20 bp match to the Pfizer reference.
Hellbound and Down 