Two research groups in the US were able to stop mice from getting old by fixing their DNA.
In a recent study published in Cell on Jan. 12, Harvard scientists showed that they could manipulate and reverse the aging process in mice by generating DNA repairs.
The results of a 13-year, international study show for the first time that breakdown in epigenetic information accelerates aging in mice and that repairing the epigenome can reverse those signs of aging.
“For about the past 50 years, popular theory has held that the process of aging is caused in large part by an accumulation of mutation. There’s growing evidence, however, that aging has a significant epigenetic component. That is, the process by which stretches of DNA or the genes are turned on and off,” said the paper’s senior author, David Sinclair, professor of genetics at the Blavatnik Institute at Harvard Medical School and co-director of the Paul F. Glenn Center for Biology of Aging Research.