Scientists dosed the first patient this week in a small clinical trial of an experimental cancer treatment—one that relies on a novel kind of ally. The treatment uses a virus engineered to selectively kill cancer cells, while also amplifying the body’s immune response to the cancer. The hope is that this therapy can help those with advanced solid tumor cancers, in combination with other existing drugs.
The CF33-hNIS virus, also called Vaxinia, was originally created by researchers at the City of Hope National Medical Center in California. It’s now being jointly developed with the company Imugene Limited.
Vaxinia is billed as an oncolytic virus, meaning it prefers to target and infect tumor cells. Scientists have been hopeful about using these kinds of viruses to directly kill off cancer cells for more than a century, but with limited success so far. In recent years, some teams have decided to explore a slightly different plan of attack. This genetically modified virus not only infects and harms cancer cells, but also forces these cells to become more recognizable to the immune system.
This strategy, the researchers hope, will then allow other treatments that also boost our immune response to cancer cells to be more effective, particularly against hard-to-target solid tumors. These treatments are collectively known as immunotherapy. In early animal and lab experiments, the virus has been shown to reduce the size of colon, lung, breast, ovarian, and pancreatic cancer tumors.