Giant, flightless bird is next target for de-extinction company Colossal Biosciences


A species of huge, flightless bird that once inhabited New Zealand disappeared around 600 years ago, shortly after human settlers first arrived on the country’s two main islands. Now, a Texas-based biotech company says it has a plan to bring it back.

Genetic engineering startup Colossal Biosciences has added the South Island giant moa — a powerful, long-necked species that stood 10 feet (3 meters) tall and may have kicked in self-defense — to a fast-expanding list of animals it wants to resurrect by genetically modifying their closest living relatives.

The company stirred widespread excitement, as well as controversy, when it announced the birth of what it described as three dire wolf pups in April. Colossal scientists said they had resurrected the canine predator last seen 10,000 years ago by using ancient DNA, cloning and gene-editing technology to alter the genetic make-up of the gray wolf, in a process the company calls de-extinction. Similar efforts to bring back the woolly mammoth, the dodo and the thylacine, better known as the Tasmanian tiger, are also underway.

To restore the moa, Colossal Biosciences announced Tuesday it would collaborate with New Zealand’s Ngāi Tahu Research Centre, an institution based at the University of Canterbury in Christchurch, New Zealand, that was founded to support the Ngāi Tahu, the main Māori tribe of the southern region of New Zealand.

The project would initially involve recovering and analyzing ancient DNA from nine moa species to understand how the giant moa (Dinornis robustus) differed from living and extinct relatives in order to decode its unique genetic makeup, according to a company statement.

“There is so much knowledge that will be unlocked and shared on the journey to bring back the iconic moa,” Ben Lamm, CEO and co-founder of Colossal Biosciences, said in the statement. For example, the company said, researching the genomes of all moa species would be “valuable for informing conservation efforts and understanding the role of climate change and human activity in biodiversity loss.”

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The Return of the Dire Wolf

Romulus and Remus are doing what puppies do: chasing, tussling, nipping, nuzzling. But there’s something very un-puppylike about the snowy white 6-month olds—their size, for starters. At their young age they already measure nearly 4 ft. long, tip the scales at 80 lb., and could grow to 6 ft. and 150 lb. Then there’s their behavior: the angelic exuberance puppies exhibit in the presence of humans—trotting up for hugs, belly rubs, kisses—is completely absent. They keep their distance, retreating if a person approaches. Even one of the handlers who raised them from birth can get only so close before Romulus and Remus flinch and retreat. This isn’t domestic canine behavior, this is wild lupine behavior: the pups are wolves. Not only that, they’re dire wolves—which means they have cause to be lonely.

The dire wolf once roamed an American range that extended as far south as Venezuela and as far north as Canada, but not a single one has been seen in over 10,000 years, when the species went extinct. Plenty of dire wolf remains have been discovered across the Americas, however, and that presented an opportunity for a company named Colossal Biosciences

Relying on deft genetic engineering and ancient, preserved DNA, Colossal scientists deciphered the dire wolf genome, rewrote the genetic code of the common gray wolf to match it, and, using domestic dogs as surrogate mothers, brought Romulus, Remus, and their sister, 2-month-old Khaleesi, into the world during three separate births last fall and this winter—effectively for the first time de-extincting a line of beasts whose live gene pool long ago vanished. TIME met the males (Khaleesi was not present due to her young age) at a fenced field in a U.S. wildlife facility on March 24, on the condition that their location remain a secret to protect the animals from prying eyes.

The dire wolf isn’t the only animal that Colossal, which was founded in 2021 and currently employs 130 scientists, wants to bring back. Also on their de-extinction wish list is the woolly mammoth, the dodo, and the thylacine, or Tasmanian tiger. Already, in March, the company surprised the science community with the news that it had copied mammoth DNA to create a woolly mouse, a chimeric critter with the long, golden coat and the accelerated fat metabolism of the mammoth.

If all this seems to smack of a P.T. Barnum, the company has a reply. Colossal claims that the same techniques it uses to summon back species from the dead could prevent existing but endangered animals from slipping into extinction themselves. What they learn restoring the mammoth, they say, could help them engineer more robust elephants that can better survive the climatic ravages of a warming world. Bring back the thylacine and you might help preserve the related marsupial known as the quoll. Techniques learned restoring the dire wolf can similarly be used to support the endangered red wolf.

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The Eastern American Puma is Officially Declared Extinct

The US Fish and Wildlife Service has officially declared the eastern American puma (scientifically named puma concolor cougar) extinct, one of the mountain lion subspecies, after removing it from the federal list of endangered and threatened wildlife of extinction.

“We determined that the eastern puma has become extinct, based on the best scientific and commercial information available. This information does not show evidence of the existence of an existing breeding population or of individuals of the eastern puma subspecies, “the official said. “It is very unlikely that an eastern puma population will remain undetected since the last confirmed sighting in 1938. Therefore, under the authority of the Endangered Species Act of 1973 we eliminated this subspecies from the federal list of endangered fauna and in Danger of extinction”.

In 1973 the eastern puma of North America had been included in the list of endangered species, but in 2011 the US Fish and Wildlife Service opened an investigation into the status of this mountain lion. It was not until 2015 when experts concluded that there was no evidence that a living population of this feline remained, so that year the Federal Register published a request to exclude the animal from the list. Finally on January 23 the statement was issued where it was officially declared extinct.

Experts believe that the last population of eastern American cougars disappeared at the hands of hunters in the state of Maine in 1938. They were killed during the eighteenth and nineteenth centuries and used to roam the forests, mountains and pastures in all US states east of Mississippi river, from Quebec (Canada) to South Carolina and from Manitoba (Canada) to Illinois. Its main prey used to be the white-tailed deer, but they also hunted eastern moose, now also extinct. In the eighty years that have passed since the last confirmed sighting, there have been some who claim to have seen them. But scientists say that it has probably been specimens from zoos and private collections.

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Forget extinction: U.S. company plans to bring back wooly mammoths

Wooly mammoths might be making a comeback thanks to Colossal Biosciences of the great state of Texas.

The Dallas-based company says it plans to take on the environmental issues that led to critical endangerment and perform the once seemingly impossible task of reviving long-extinct species.

Colossal announced it will pioneer the use of CRISPR technology along with other genome engineering technologies toward a practical working model of de-extinction initially focused on its long-term goals of successful restoration and rewilding of functional woolly mammoths, large proboscideans from the Ice Age, to the tundra, according to a press release.

It said genetic engineering applications expand beyond animals and have the potential to advance human health, enhance food production, reduce environmental impact, and optimize animal health and welfare.

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Monarch butterfly population moves closer to extinction

But the count this year is dismal. At iconic monarch wintering sites in the city of Pacific Grove, volunteers didn’t see a single butterfly this winter. Other well-known locations, such as Pismo State Beach Monarch Butterfly Grove and Natural Bridges State Park, only hosted a few hundred butterflies, researchers said.

“These sites normally host thousands of butterflies, and their absence this year was heartbreaking for volunteers and visitors flocking to these locales hoping to catch a glimpse of the awe-inspiring clusters of monarch butterflies,” said Sarina Jepsen, director of endangered species at the Xerces Society.

Scientists say the butterflies are at critically low levels in western states because of destruction to their milkweed habitat along their migratory route as housing expands into their territory and use of pesticides and herbicides increases.

Researchers also have noted the effect of climate change. Along with farming, climate change is one of the main drivers of the monarch’s threatened extinction, disrupting an annual 3,000-mile (4,828-kilometer) migration synched to springtime and the blossoming of wildflowers. Massive wildfires throughout the U.S. West last year may have influenced their breeding and migration, researchers said.

A 2017 study by Washington State University researchers predicted that if the monarch population dropped below 30,000, the species would likely go extinct in the next few decades if nothing is done to save them.

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