Researchers in a landmark new study have discovered a sequence within the Pfizer mRNA vaccine that produces an “unintended immune response” in the body, which experts are calling a massive “developmental and regulatory failure.”
Synthetic Messenger Ribonucleic Acid (mRNA), such as that used in Moderna and Pfizer vaccines, enables the body to create a specific spike protein mimicking SARS-CoV-2. The body reacts to the foreign protein and generates protective immunity, which theoretically neutralizes the real virus when it enters the body.
“Researchers from the Medical Research Council (MRC) Toxicology Unit have discovered that the cellular machinery that ‘reads’ mRNAs ‘slips’ when confronted with repeats of a chemical modification commonly found in mRNA therapeutics. In addition to the target protein, these slips lead to the production of ‘off-target’ proteins triggering an unintended immune response,” said a press release for the study published in Nature on Dec. 6.
The MRC team redesigned the mRNA vaccine to prevent further harmful immune responses from the spike proteins.
“The researchers identified that bases with a chemical modification called N1-methylpseudouridine—which are currently contained in mRNA therapies—are responsible for the ‘slips’ along the mRNA sequence.”
When the MRC team collaborated with researchers from the Universities of Kent, Oxford, and Liverpool, they found an unintended immune response occurred in one-third of the 21 patients in the study who were inoculated with the Pfizer mRNA vaccine.
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