A large nationwide study of more than 4 million people in New Zealand identified a statistically significant association in two adverse events following vaccination with Pfizer’s COVID-19 vaccine.
In the post-marketing safety study recently published in Springer, researchers examining 12 specific adverse events found an increase in myopericarditis during the 21-day period following both Pfizer vaccine doses. Myopericarditis describes two distinct inflammatory heart conditions that occur simultaneously, myocarditis and pericarditis.
The highest rate of myopericarditis was observed in the youngest participants under 39 years of age following the second vaccine dose—with an estimated five additional myopericarditis cases per 100,000 persons vaccinated regardless of age. Researchers also observed an increase following both vaccine doses in individuals aged 40 to 59.
“Our findings align with international postmarketing studies, case series reports, and cases detected through reports to New Zealand’s spontaneous system that identify an association between the BNT162b2 vaccine and myo/pericarditis, especially in younger people and after the second dose,” the researchers stated.
In addition to myopericarditis, the study found an increase in single-organ cutaneous vasculitis (SOCV) in the 20- to 39-year-old age group following the first vaccine dose. SOCV is a syndrome characterized by inflammation and damage to the skin’s blood vessels without the involvement of other organ systems.
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