Researchers are expected to begin human clinical trials in early 2024 to test the safety and efficacy of vaccines to prevent heroin and fentanyl overdoses. While there is still a way to go, if approved, the vaccines could revolutionize the treatment of opioid addiction and reduce the number of deaths resulting from overdose.
Opioids – especially synthetic opioids – are the main driver of drug-related overdose deaths. The availability of drugs like heroin and fentanyl continues to feed the problem of opioid dependence and places users at risk of death. They’re also difficult drugs to quit.
Drug use and associated overdoses not only burden the loved ones of the person who died, but they also inflict an economic burden. In 2017, the costs for opioid use disorder and fatal opioid overdose in the US were estimated to be US$1.02 trillion.
While the streets are unlikely to ever be clear of drugs like heroin and fentanyl – and, even if they were, they’d probably be replaced by other, equally damaging drugs – researchers at the University of Montana (UM) are close to trialing the next best thing in tackling the opioid epidemic: vaccines to prevent fentanyl and heroin overdose and aid in treating opioid dependence.
The development of the vaccines began with Marco Pravetoni, a professor of psychiatry and behavioral sciences at the University of Washington, who, along with his research team, has been working on vaccines against opioids for more than 10 years.
Hellbound and Down 