Bioengineers have used artificial intelligence (AI) to bring molecules back from the dead1.
To perform this molecular ‘de-extinction’, the researchers applied computational methods to data about proteins from both modern humans (Homo sapiens) and our long-extinct relatives, Neanderthals (Homo neanderthalensis) and Denisovans. This allowed the authors to identify molecules that can kill disease-causing bacteria — and that could inspire new drugs to treat human infections.
“We’re motivated by the notion of bringing back molecules from the past to address problems that we have today,” says Cesar de la Fuente, a co-author of the study and a bioengineer at the University of Pennsylvania in Philadelphia. The study was published on 28 July in Cell Host & Microbe1.
Hellbound and Down 