A gene that was carried by both Neanderthals and Denisovans causes mice to develop larger heads, twisted ribs, and shortened spines, according to the results of a yet-to-be-published study. Researchers used CRISPR gene editing technology to insert the ancient genetic code into rodents in order to understand how it might have contributed to the body shape of our extinct relatives.
The gene in question is known as GLI3 and plays a vital role in embryonic development in modern humans. Mutations within this gene are associated with physical malformations such as polydactyly – which refers to the growth of extra fingers or toes – and the deformation of the skull.
Neanderthals and Denisovans both carried a slightly altered version of the GLI3 gene, in which an amino acid at one end of the coding region is substituted. However, neither of these ancient species had an abnormal number of digits or life-threatening cranial defects.
As the study authors point out, though, these extinct hominid species displayed several morphological characteristics that differed from those of modern humans, “including elongated and low crania, larger brow ridges, and broader rib cages.”
To determine how the ancient form of the GLI3 gene might have affected the development of our extinct cousins, the researchers first engineered mice to carry a faulty version of the gene. This caused the rodents to develop severe skull and brain deformities as well as polydactyly, illustrating how a functioning version of the gene is essential for healthy embryonic growth.
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