USC researchers think THC in marijuana may be able to treat deadly COVID complication

Top University of South Carolina researchers think the chemical in marijuana that induces a “high” may be effective in treating a potentially lethal coronavirus complication, according to three newly released studies

The studies, co-published by Prakash Nagarkatti, found THC, the most potent mind-altering chemical in cannabis, can — in mice — prevent a harmful immune response that causes Acute Respiratory Distress Syndrome (ARDS) and cause a significant increase in healthy lung bacteria.

The studies, published in Frontiers in Pharmacology, the British Journal of Pharmacology and the International Journal of Molecular Sciences, were conducted by giving mice a toxin that triggered the harmful immune reaction that causes ARDS and then injecting mice with THC, according to the studies’ abstracts.

“The underlying mechanism is your immune system goes haywire and starts destroying your lungs and all your other organs,” Nagarkatti said of ARDS.

“Its’ like a car where you’re putting on a lot of accelerator, but the brakes aren’t working,” Nagarkatti said. “Basically what’s going to happen is your car is going to crash because you can’t stop it. And that’s basically what’s happening with ARDS.”

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CDC: 94% of Covid-19 deaths had underlying medical conditions

The Centers for Disease Control released information showing how many people who died from COVID-19 had underlying medical conditions that attributed to their death.

Click here to read the entire report from the CDC.

The CDC said:

Table 3 shows the types of health conditions and contributing causes mentioned in conjunction with deaths involving coronavirus disease 2019 (COVID-19). For 6% of the deaths, COVID-19 was the only cause mentioned. For deaths with conditions or causes in addition to COVID-19, on average, there were 2.6 additional conditions or causes per death.

The following are the top underlying medical conditions linked with COVID-19 deaths.

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Researchers fast-track coronavirus vaccine by skipping key animal testing first

A clinical trial for an experimental coronavirus vaccine has begun recruiting participants in Seattle, but researchers did not first show that the vaccine triggered an immune response in animals, as is normally required. 

Now, biomedical ethicists are calling the shortcut into question, according to Stat News.

“Outbreaks and national emergencies often create pressure to suspend rights, standards and/or normal rules of ethical conduct,” Jonathan Kimmelman, director of McGill University’s biomedical ethics unit, wrote in an email to Stat News. “Often our decision to do so seems unwise in retrospect.”

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Delaying herd immunity is costing lives

Because of its virulence, wide spread and the many asymptomatic cases it causes, Covid-19 cannot be contained in the long run, and so all countries will eventually reach herd immunity. To think otherwise is naive and dangerous. General lockdown strategies can reduce transmission and death counts in the short term. But this strategy cannot be considered successful until lockdowns are removed without the disease resurging.

The choice we face is stark. One option is to maintain a general lockdown for an unknown amount of time until herd immunity is reached through a future vaccine or until there is a safe and effective treatment. This must be weighed against the detrimental effects that lockdowns have on other health outcomes. The second option is to minimise the number of deaths until herd immunity is achieved through natural infection. Most places are neither preparing for the former nor considering the latter.

The question is not whether to aim for herd immunity as a strategy, because we will all eventually get there. The question is how to minimise casualties until we get there. Since Covid-19 mortality varies greatly by age, this can only be accomplished through age-specific countermeasures. We need to shield older people and other high-risk groups until they are protected by herd immunity.

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Face masks make you stupid

Face masks can now be added to the list of mandates that make you stupid. As if Piers Morgan feverishly promoting them weren’t evidence enough, here are the facts on why you absolutely, categorically should not wear a face mask. They make you suggestible; they make you more likely to follow someone else’s direction and do things you wouldn’t otherwise do. In short, they switch off your executive function – your conscience.

A great example comes from a study by Mathes and Guest (1976), who asked participants how willing they would be, and how much they would have to be paid, to carry a sign around the university cafeteria reading “masturbation is fun” (this being 1976, doing such a thing would be considered embarrassing; these days it will probably earn you a course credit!). The results showed that when people wore a mask, they were more likely to carry the sign and required less money to do so ($30 compared to $48, on average).

Meanwhile, Miller and Rowold (1979) presented Halloween trick-or-treaters with a bowl of chocolates and told them they were allowed to take only two each. When the children thought they weren’t being watched, they helped themselves. Children without a mask broke the rule, taking more chocolates, 37% of the time, compared to 62% for masked children. The authors concluded that masks “lead to lower restraints on behaviour”.

The effect has similarly been found online: the online disinhibition effect refers to the tendency for people to act antisocially when anonymous online (Suler, 2004). There is even an infamous trolling movement calling itself Anonymous and using a mask as its symbol.

The disinhibiting effects of wearing a mask are described by psychologists in terms of a suspension of the superego’s control mechanisms, allowing subconscious impulses to take over. Saigre (1989) wrote that masks ‘short-cut’ conscious defence systems and encourage “massive regression” to a more primitive state; Castle (1986) wrote that eighteenth century masquerades allowed mask-wearers to release their repressed hedonistic and sexual impulses; and Caillois (1962) similarly wrote about European masked carnivals involving libidinal activities including “indecencies, jostling, provocative laughter, exposed breasts, mimicking buffoonery, a permanent incitement to riot, feasting and excessive talk, noise and movement”. In the 12th Century, Pope Innocent III banned masks as part of his fight against immorality; and in 1845, New York State made it illegal for more than two people to wear masks in public, after farmers wore masks to attack their landlords.

From a neuroimaging perspective, masks are known to inhibit identity and impulse control – both associated with executive function in the prefrontal cortex (e.g., Glannon, 2005; Tacikowski, Berger & Ehrsson, 2017). In other words, masks silence the Jiminy Cricket in the brain.

It is little wonder that covering our mouths would ‘shut us up’ psychologically. Studies have shown that clothing has a powerful effect on how we think (or not), via a principal known as enclothed cognition: wearing a lab coat enhances cognitive function (Adam & Galinsky, 2012), wearing a nurse’s scrubs increases empathy (López-Pérez et al., 2016), and wearing counterfeit brands increases the likelihood of cheating in a test (Gino, Norton & Ariely, 2010). Similarly, in the world of body language, someone putting their hand over their mouth is a sign that they are listening intently: they are ready to receive information, not to question it.

While no studies have looked at the effect of masks on verbal reasoning, it is fairly safe to assume that priming a ‘shutting up’ would have a cognitive effect. For example, extraverts are less compliant than introverts (Cohen et al., 2004; Gudjonsson et al., 2004); the development of conscience in humans is heavily linked to that of language (e.g., Arbib, 2006); and inner speech is highly related to cognitive functions (Alderson-Day & Fernyhough, 2015). Crucially, verbal reasoning is strongly correlated with moral reasoning (e.g., Hayes, Gifford & Hayes, 1998): being unable to ‘speak’ makes one less able to deduce what is moral and immoral behaviour.

There is also a more basic reason masks might make you stupid: decreasing oxygen flow to the brain. Face veils reduce ventilatory function in the long-term (Alghadir, Aly & Zafar, 2012), and surgical masks may reduce blood oxygenation among surgeons (Beder et al., 2008): believe it or not, covering your mouth makes it harder to breathe. Reviewing the N95 face mask, a 2010 study (Roberge et al.) concluded that “carbon dioxide and oxygen levels were significantly above and below, respectively, the ambient workplace standards” inside the mask. A post-COVID study found that 81% of 128 previously-fit healthcare workers developed headaches as a result of wearing personal protective equipment (Ong et al., 2020).

Not only do face masks make it hard to breathe, but the evidence that they even work to stop the spread of coronavirus is limited at best. A popular brand of mask even carries a warning on its packaging that it “will not provide any protection against COVID-19”; as for preventing carriers from spreading the disease, a meta-analysis found, for example, that of eight randomised control trial studies, six found no difference in transmission rates between control and intervention groups (while one found that a combination of masks and handwashing is more effective than education alone, and the other found that N95 masks are more effective than standard surgical masks; bin-Reza et al., 2012). Non-surgical masks, such as scarfs and cloths, are almost useless (Rengasamy et al., 2010). Masks may even be unhealthy, causing a build-up of bacteria around the face (Zhiqing et al., 2018).

The fact that masks likely don’t even work brings us to the final reason that wearing one inculcates stupidity and compliance: through a bombardment of lies, contradictions, and confusion, the state overwhelms your ability to reason clearly.

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