A clinical trial examined the effects of psilocybin combined with psychological support on cancer patients diagnosed with major depressive disorder. Results showed that a single dose of psilocybin had robust antidepressant effects in these individuals. Fifty percent demonstrated sustained depression reduction, while 43% experienced a sustained reduction in anxiety. The research was published in the journal Cancer.
Depression is a mental health condition that involves persistent sadness, loss of interest, and feelings of hopelessness. It is often accompanied by anxiety, which is characterized by excessive fear, worry, and physical tension. Both conditions are common psychological responses to the challenges of living with cancer.
Cancer patients often face uncertainty about their prognosis, undergo painful treatments, and experience changes in physical functioning, all of which can heighten anxiety. Depression may develop as a response to the emotional burden of diagnosis, fatigue, changes in body image, or loss of independence. These conditions can negatively affect treatment adherence, as patients may avoid appointments or struggle to follow medical recommendations.
Anxiety can also intensify physical symptoms such as pain, nausea, or insomnia, creating a cycle of distress. Depression may reduce motivation and energy, limiting the patient’s ability to engage in daily activities and draw on social support. Emotional distress in cancer patients is associated with a poorer quality of life and, in some studies, worse clinical outcomes.
Study author Manish Agrawal and his colleagues explored the impact of psilocybin combined with psychological support in 30 patients with cancer and a diagnosis of major depressive disorder. Some had curable, and others had incurable forms of cancer. The average age of participants was 57.5 years, and 19 were female. None were hospitalized for depression at baseline, and 61% were not receiving psychiatric medications. During the course of the study, two patients died, reducing the number of participants in the final analysis to 28.
Hellbound and Down 