Marijuana and its cannabinoid components may be useful treatments for various types of chronic pain, in some cases helping to reduce the use of other medications, according to a newly published scientific review. The paper also says select mixtures of cannabinoids could help minimize undesirable effects of cannabis, such as the psychoactivity of THC.
Published last month in the journal Medical Cannabis and Cannabinoids and authored by researchers at Penn State College of Medicine, the paper reviews “the most recent evidence supporting the use of cannabis in the treatment of chronic pain disorders including chronic neuropathic pain, cancer-induced neuropathic pain, chronic musculoskeletal pain, and chronic headaches and migraines.”
The report concludes that a selection of cannabis compounds, with various effects on chemical receptors in the body, can have a pain-relieving effect. It also recommends further research into the possible analgesic properties of less-common cannabinoids such as cannabichromene (CBC) and cannabigerol (CBG).
All told, more than 180 different cannabinoids have now been isolated from the cannabis plant, the report notes, often interacting with different parts of the body. CBD and THC, for example, “have a wide potential for therapeutic effects based on their multiple molecular targets including ion channels, receptors, transporters and enzymes.”
“The two most abundant and studied cannabinoids, THC and CBD, along with an understudied cannabinoid, cannabigerol (CBG), have been shown, in our laboratories, to reduce neuropathic pain in animal models,” authors wrote, recommending that further study “into cannabinoids like THC, CBD and CBG should focus on the optimal therapeutic doses and the effects these cannabinoids can have on the management of chronic neuropathic pain in humans.”
Chronic pain affects more than 100 million Americans, the review says, and is one of the most common reasons adults seek medical care.
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