Japan is offering a self-amplifying mRNA vaccine as one of the five routine COVID-19 vaccines available to the public for the 2024-2025 fall and winter seasons.
Japanese regulators approved the ARCT-154 shot in November 2023. According to a press release, ARCT-154 is the world’s first self-amplifying mRNA COVID-19 vaccine. Japan’s Ministry of Health, Labour and Welfare approved the vaccine for adults. It is jointly produced by the biotechnology firm CSL and Arcturus Therapeutics.
“The approval is based on positive clinical data from several ARCT-154 studies … which achieved higher immunogenicity results and a favorable safety profile compared to a standard mRNA COVID-19 vaccine comparator,” CSL said.
Japan’s vaccination program will offer the vaccines to people 65 and over, and 60- to 64-year-olds with severe underlying conditions, at a maximum cost of 7,000 yen (approximately $47). People not in these two categories can also receive the shots, but the fee will not be capped.