In 2001, Gina Arata was in her final semester of college, planning to apply to law school, when she suffered a traumatic brain injury in a car accident. The injury so compromised her ability to focus she struggled in a job sorting mail.
“I couldn’t remember anything,” said Arata, who lives in Modesto with her parents. “My left foot dropped, so I’d trip over things all the time. I was always in car accidents. And I had no filter—I’d get pissed off really easily.”
Her parents learned about research being conducted at Stanford Medicine and reached out; Arata was accepted as a participant. In 2018, physicians surgically implanted a device deep inside her brain, then carefully calibrated the device’s electrical activity to stimulate the networks the injury had subdued. The results of the clinical trial were published Dec. 4 in Nature Medicine.
She noticed the difference immediately. When she was asked to list items in the produce aisle of a grocery store, she could rattle off fruits and vegetables. Then a researcher turned the device off, and she couldn’t name any.
“Since the implant I haven’t had any speeding tickets,” Arata said. “I don’t trip anymore. I can remember how much money is in my bank account. I wasn’t able to read, but after the implant I bought a book, ‘Where the Crawdads Sing,’ and loved it and remembered it. And I don’t have that quick temper.”
For Arata and four others, the experimental deep-brain-stimulation device restored, to different degrees, the cognitive abilities they had lost to brain injuries years before. The new technique, developed by Stanford Medicine researchers and collaborators from other institutions, is the first to show promise against the long-lasting impairments from moderate to severe traumatic brain injuries.
Hellbound and Down 