Legalizing medical marijuana is associated with a “lower frequency” of nonprescribed pharmaceutical opioid use, according to a study published this month in the International Journal of Mental Health and Addiction.
While the decrease was rather small—between about 0.6 percent and 1.5 percent for regular to frequent opioid use—and was concentrated in people who met diagnostic criteria for cannabis use disorder, the researchers said it could signal “substitution effects with partial replacement of opioids by cannabis.”
The research team, from the schools of public health at Rutgers and Columbia universities as well as the University of Arizona’s School of Government and Public Policy, said the results highlight “the importance of identifying tradeoffs of cannabis legalization as an intervention to reduce opioid-related harms.”
The study used national survey data from 2004 to 2014 to examine nonmedical prescription opioid (NMPO) use—specifically, prescription opioids used without a prescription or in a manner other than prescribed.
Despite the decrease in regular and frequent opioid use, the study also found that medical cannabis legalization (MCL) was associated with a 2.1 percent increase in the occasional use of nonmedical prescription opioids, defined as between once and 12 times per year.
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