House investigators on the Energy and Commerce Committee released a 73-page report yesterday documenting NIH officials lying about dangerous gain-of-function virus research to reporters and withholding information from Congress. These latest revelations follow reporting last week that Tony Fauci lied to the New York Times about his involvement in a Nature Medicine piece that advanced the theory that the pandemic could not have started in a lab Fauci himself was funding in Wuhan, China.
The House began the investigation following a September 2022 article in Science Magazine that reported on the dangers of monkeypox virus, spreading across the globe with the potential to adapt to humans and become more transmissible or deadly. Bernard Moss, a veteran poxvirus researcher at the NIH’s National Institute of Allergy and Infectious Diseases (NIAID), told Science Magazine that monkeypox evolves to replicate faster in humans.
Science noted that Moss had begun gain-of-function experiments—swapping out genes from various variants—to understand why some are more dangerous or transmissible than others.
Moss has been trying for years to figure out the crucial difference between two variants of monkeypox virus: clade 2, which until recently was found only in West Africa and is now causing the global outbreak, and clade 1, believed to be much deadlier, which has caused outbreaks in the Democratic Republic of Congo for many decades. He’s found that clade 1 virus can kill a mouse at levels 1000 times lower than those needed with clade 2. To find out why, Moss and his colleagues swapped dozens of clade 2 genes, one at a time, into clade 1 virus, hoping to see it become less deadly, but with no luck so far. Now, they are planning to try the opposite, endowing clade 2 virus with genes from its deadlier relative.
Moss’s disclosure that he planned to insert genes from the more deadly clade 1 monkeypox strain into the more common and transmissible clade 2 monkeypox virus triggered a second story in Science Magazine with scientists expressing alarm at the study’s dangers.
On the other hand, Ohio State University researcher Linda Saif told Science Magazine’s Jocelyn Kaiser that she was worried that excessive regulation could “greatly impede research into evolving or emerging viruses” and drive research overseas, where U.S. regulations don’t apply or are looser. Oddly enough, I previously reported that Saif helped orchestrate a February 2020 essay ghostwritten by Shi Zhengli of the Wuhan Institute of Virology that called the possibility of a Wuhan lab accident a “conspiracy.”
Hellbound and Down 