Top U.S. virologist Ralph Baric engineered the COVID-19 virus SARS-CoV-2 in his lab at the University of North Carolina as part of his work in connection with the 2018 DEFUSE funding proposal. That’s the story that’s been going round the internet for some months now (and not just in alternative media) and it all looks very damning for Baric and those connected with his research. Details of the DEFUSE project were first leaked by Major Joseph Murphy, an employee of U.S. military research agency DARPA, in the summer of 2021 and further details of earlier drafts have come to light this month thanks to public record requests from U.S. Right to Know (USRTK).
In DEFUSE, Baric proposed to create a virus that was, to most intents and purposes, SARS-CoV-2. The proposal included inserting a furin cleavage site into a coronavirus spike protein, an order for the restriction enzyme BsmBI, the search for a binding domain that would infect ACE2 human receptors and a requirement for a viral genome around 25% different to SARS.
The SARS-CoV-2 virus contains a furin cleavage site in its spike protein, its genome includes the restriction enzyme BsmBI, it has a receptor binding domain finely tuned to infect the ACE2 human receptor and its genome is around 25% different to SARS. A number of virologists have said that such features make SARS-CoV-2 a smoking gun for an engineered virus.
Baric obtained a patent for such novel viruses in 2018, just as he was putting DEFUSE together. In DEFUSE he proposed to infect wild Chinese bats with his newly patented viruses.
Many regard this as case closed for the lab leak.