Many chronic inflammatory diseases and mental health conditions affecting military service members and veterans involve abnormal activity in the peripheral nervous system, which plays a key role in organ function. Monitoring and targeted regulation of peripheral nerve signals offer great promise to help patients restore and maintain their health without surgery or drugs. Current neuromodulation devices are typically used as a last resort, however, because they are relatively large (about the size of a deck of cards), require invasive surgical implantation and often produce side effects due to their lack of precision. DARPA’s Electrical Prescriptions (ElectRx) program is seeking innovative research proposals to help transform neuromodulation therapies from last resort to first choice for a wide range of diseases.
ElectRx (pronounced “electrics”) aims to develop groundbreaking technologies that would use the body’s innate neurophysiology to restore and maintain health. In support of the White House’s brain initiative, ElectRx also seeks to accelerate understanding of specific neural circuits and their role in health and disease. Future therapies based on targeted peripheral neural stimulation could promote self-healing, reduce dependence on traditional drugs and provide new treatment options for illnesses.
ElectRx would leverage advanced sensing and stimulating technologies to target specific peripheral neural circuits that control organ functions. These feedback-controlled neuromodulation technologies would monitor health status and intervene as needed to deliver patient-specific therapeutic patterns of stimulation designed to restore a healthy physiological state. The program seeks to create ultraminiaturized devices that would require only minimally invasive insertion procedures such as injectable delivery through a needle.
Hellbound and Down 