Could magic mushrooms hold the key to slowing down aging? New research from Georgia’s Emory University suggests they just might.
A new study has found that psilocin—a compound produced in the body after consuming psilocybin, the active ingredient in psychedelic mushrooms—extended the lifespan of human skin and lung cells in the lab by more than 50 percent.
The researchers also found that mice treated with psilocybin lived 30 percent longer—not to mention more healthily—than their peers.
“This study provides strong preclinical evidence that psilocybin may contribute to healthier aging—not just a longer lifespan, but a better quality of life in later years,” Dr. Ali John Zarrabi, Director of Psychedelic Research at Emory University’s Department of Psychiatry said in a statement.
“As a palliative care physician-scientist, one of my biggest concerns is prolonging life at the cost of dignity and function. But these mice weren’t just surviving longer—they experienced better aging,” added Zarrabi, who co-led the study.
As part of their study, the researchers ran the first long-term assessment of psilocybin’s systemic effects in living animals.
They treated aged, 19-month-old mice—which is something like 60–65 in human years—with an initially low psilocybin dose of 5 mg, followed by a high dose of 15 mg every month for 10 months.
The team found that psilocybin-treated mice survived around 30 percent longer than their untreated peers. Moreover, the treated mice also looked healthier for it, with better fur quality, fewer white hairs and even hair regrowth.
While psilocybin is usually studied for its mental health benefits, the findings suggest that the compound may also tackle key drivers of aging.
According to the team, the psilocybin treatments reduced oxidative stress, improved the cells’ ability to repair DNA and helped preserve the length of telomeres—the protective caps on chromosomes that guard against damage leading to diseases like cancer, neurodegeneration and heart disease.
“Most cells in the body express serotonin receptors, and this study opens a new frontier for how psilocybin could influence systemic aging processes, particularly when administered later in life,” said senior author and former Emory professor Louise Hecker in a statement.
Though psilocybin may be best known for its hallucinogenic effects on the brain, most cells in the body have serotonin receptors, suggesting it could have much wider impacts.
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