You probably have never heard of 2,5-dimethoxy-4-iodoamphetamine (DOI), let alone heard that it is commonly abused. Yet the Drug Enforcement Administration (DEA) wants to ban the synthetic psychedelic, a promising research chemical that has figured in more than 900 published studies, by placing it in Schedule I of the Controlled Substances Act, a category supposedly reserved for drugs with a high abuse potential and no recognized medical applications—drugs so dangerous that they cannot be used safely, even under a doctor’s supervision. Students for Sensible Drug Policy (SSDP), which defeated a previous DEA attempt to ban DOI in 2022, is determined to stop that move again.
On Tuesday, acting on behalf of more than 20 scientists, SSDP filed a prehearing statement objecting to DOI’s placement in Schedule I. That step, SSDP notes, would impose “onerous financial and bureaucratic obstacles on researchers,” since “obtaining a Schedule I license involves a daunting array of red tape and substantial costs, which can be prohibitive for many research institutions, particularly smaller labs and academic departments.” SSDP also opposes the scheduling of another psychedelic, 2,5-dimethoxy-4-chloroamphetamine (DOC), that is covered by the same proposed rule, which the DEA published on December 13.
“DOI and DOC are important research chemicals with basically no evidence of abuse,” says SSDP attorney Brett Phelps. “We are excited to fight on behalf of SSDP scientists so that they can continue the critical work they are doing with these substances.”
Phelps is working with Denver attorney Robert Rush, who represents University of California, Berkeley, neuroscientist Raul Ramos. “The DEA’s attempt to classify DOI, a compound of great significance to both psychedelic and fundamental serotonin research, as a Schedule I substance exemplifies an administrative agency overstepping its bounds,” Rush says. “The government admits DOI is not being diverted for use outside of scientific research yet insists on placing this substance in such a restricted class that it will disrupt virtually all current research.”
Hellbound and Down 