In April 1960, a Dow Chemicals biochemist named Alexander Shulgin consumed 400mg of a compound called mescaline, and had his first psychedelic experience. He saw “hundreds of nuances of color” that he had never seen before. “The world amazed me,” Shulgin later wrote. “I saw it as I had when I was a child. I had forgotten the beauty and the magic and the knowingness of it and me.” He found the encounter so extraordinary, that he dedicated the rest of his life to uncovering the secrets that psychedelic chemistry could contain.
“I understood that our entire universe is contained in the mind and the spirit,” Shulgin recalled. “We may choose not to find access to it, we may even deny its existence, but it is indeed there inside us, and there are chemicals that can catalyze its availability.” However, it struck him as curious why scant work had been done on compounds, known as phenethylamines, which are similar to mescaline—the psychedelic derived from peyote that was first isolated in 1897. The trip, “unquestionably confirmed the entire direction” of his life, he wrote in his 1991 classic PiHKAL: A Chemical Love Story. “I had found my learning path.”
Shulgin, known as “Sasha,” was a hero to the psychedelic counterculture, but not necessarily a movement insider, went on to make the psychedelic experience more accessible than anyone else in history. He worked out of a ramshackle backyard lab on his 20-acre ranch in Lafayette, California, and discovered more than 200 new psychedelic compounds. A number of his compounds became popular, notably 2C-B (also known as “tripstasy”). He also tripped several thousand times himself, before he died in 2014 aged 88.
He informally established the Alexander Shulgin Research Institute (ASRI), during the 1980s at a time when “the mere mention of psychedelics, even in the freedom-of-thought world of academia, was a career killer,” the ASRI says on its website. Today, the institute continues Shulgin’s psychedelic legacy. It was officially incorporated on Bicycle Day on 19 April 2021 by his wife Ann, before she died in 2022. Two of his long-time research colleagues, Paul Daley, and Nicholas Cozzi, took up leadership roles following Shulgin’s death. The institute is creating new psychedelics, which it is patenting, and scouring the vault of Shulgin’s creations for any overlooked gems.
Hellbound and Down 